GB1382769A - 3-substituted phenothiazine derivatives - Google Patents

3-substituted phenothiazine derivatives

Info

Publication number
GB1382769A
GB1382769A GB810373A GB810373A GB1382769A GB 1382769 A GB1382769 A GB 1382769A GB 810373 A GB810373 A GB 810373A GB 810373 A GB810373 A GB 810373A GB 1382769 A GB1382769 A GB 1382769A
Authority
GB
United Kingdom
Prior art keywords
propyl
ethyl
methyl
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB810373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to GB810373A priority Critical patent/GB1382769A/en
Priority to ES423414A priority patent/ES423414A1/en
Priority to JP1932874A priority patent/JPS5029585A/ja
Priority to DE19742407938 priority patent/DE2407938A1/en
Priority to FR7405506A priority patent/FR2218102A1/fr
Priority to BE141115A priority patent/BE811259A/en
Publication of GB1382769A publication Critical patent/GB1382769A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1382769 10-Aminoalkylene phenothiazines LABORATORIOS DEL DR ESTEVE SA 19 Feb 1973 8103/73 Heading C2C Novel compounds I in which R is an alkyl or alicyclic group of up to 8 C atoms, R 1 is hydrogen and R 2 is methyl, ethyl or propyl or R 1 is methyl, ethyl or propyl and R 2 is hydrogen or R 1 and R 2 are the same and are hydrogen, methyl, ethyl or propyl and X is a group -N(A)B in which A and B are C 3-6 alkyl or a group N(CH 2 ) n in which n is 4 to 7, are prepared by (1) alkylation of a 3-R- phenothiazine with a dialkylaminoethyl halide X-CH(R 2 )-CH(R 1 )-Hal in the presence of an alkali metal amide, hydride, alcoholate or hydroxide and in an inert solvent or (2) reacting a diphenylamine II with sulphur and iodine or sulphurmonochloride. They may also be prepared by displacement of dimethylamine from the side chain of a phenothiazine by a less voltatile amine (pyrrolidine, piperidine or hexamethylene). Compounds I inhibit the effects of lustamine at H 2 receptors and have CNS and cardiovascular activities. They form with a carrier a pharmaceutical composition which may be administered orally.
GB810373A 1973-02-19 1973-02-19 3-substituted phenothiazine derivatives Expired GB1382769A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB810373A GB1382769A (en) 1973-02-19 1973-02-19 3-substituted phenothiazine derivatives
ES423414A ES423414A1 (en) 1973-02-19 1974-02-14 3-substituted phenothiazine derivatives
JP1932874A JPS5029585A (en) 1973-02-19 1974-02-18
DE19742407938 DE2407938A1 (en) 1973-02-19 1974-02-19 3-10 SUBSTITUTED PHENOTHIAZINE DERIVATIVES
FR7405506A FR2218102A1 (en) 1973-02-19 1974-02-19
BE141115A BE811259A (en) 1973-02-19 1974-02-19 PHENOTHIAZINE 3-SUBSTITUTES AND THEIR PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB810373A GB1382769A (en) 1973-02-19 1973-02-19 3-substituted phenothiazine derivatives

Publications (1)

Publication Number Publication Date
GB1382769A true GB1382769A (en) 1975-02-05

Family

ID=9845823

Family Applications (1)

Application Number Title Priority Date Filing Date
GB810373A Expired GB1382769A (en) 1973-02-19 1973-02-19 3-substituted phenothiazine derivatives

Country Status (6)

Country Link
JP (1) JPS5029585A (en)
BE (1) BE811259A (en)
DE (1) DE2407938A1 (en)
ES (1) ES423414A1 (en)
FR (1) FR2218102A1 (en)
GB (1) GB1382769A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5398844U (en) * 1976-12-30 1978-08-10
JPS54138364U (en) * 1978-03-16 1979-09-26
JPS62172930A (en) * 1986-01-24 1987-07-29 成見　年生 Fiber product having piles each divided at leading end thereof and its production
US4752985A (en) * 1986-06-13 1988-06-28 Golden Star, Inc. Closed end mops
US4750234A (en) * 1986-06-13 1988-06-14 Golden Star, Inc. Closed end wet mops
AU2007290386A1 (en) * 2006-09-01 2008-03-06 Immune Control, Inc. Novel compositions and methods for treatment of diseases related to activated lymphocytes

Also Published As

Publication number Publication date
DE2407938A1 (en) 1974-08-22
BE811259A (en) 1974-06-17
ES423414A1 (en) 1976-05-16
JPS5029585A (en) 1975-03-25
FR2218102A1 (en) 1974-09-13

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees