GB1382608A - Vincaminic acid derivatives and their preparation - Google Patents
Vincaminic acid derivatives and their preparationInfo
- Publication number
- GB1382608A GB1382608A GB4771872A GB4771872A GB1382608A GB 1382608 A GB1382608 A GB 1382608A GB 4771872 A GB4771872 A GB 4771872A GB 4771872 A GB4771872 A GB 4771872A GB 1382608 A GB1382608 A GB 1382608A
- Authority
- GB
- United Kingdom
- Prior art keywords
- vincaminate
- acid
- vincaminic acid
- vincaminic
- vincamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1382608 Vincaminic acid and derivatives thereof OMNIUM CHIMIQUE SA 17 Oct 1972 [25 Oct 1971 31 Dec 1971] 47718/72 Heading C2C The invention comprises aminoethyl esters of vincaminic acid of the formula in which the R groups are alkyl groups or together with the nitrogen to which they are attached form a substituted or unsubstituted heterocyclic group, and their hydrochloride salts. The esters may be prepared by (a) condensing vincaminic acid with a substituted aminoethyl halide of formula (R) 2 NCH 2 CH 2 X in which X is a halogen in the presence of an organic solvent and an alkali metal carbonate insoluble in thereaction mixture; (b) reacting the hydrochloride of an aminoethyl halide as in (a) with an alkali metal salt of vincaminic acid in the presence of an insoluble acid acceptor, anhydrous potassium acetate and an organic solvent; and (c) reacting vincamine with an aminoalcohol of formula (R) 2 NCH 2 CH 2 OH. The starting material, vincaminic acid, may be obtained by the saponification of vincamine or 16-epi-vincamine. Examples describe the preparation of dimethylamino ethyl vincaminate, morpholinoethyl vincaminate, pyrrolidinoethyl vincaminate and piperidinoethyl vincaminate which are isolated as their hydrochlorides.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE774422A BE774422A (en) | 1971-10-25 | 1971-10-25 | N-disubstd-amino-ethyl vincaminic acid esters - useful as medicaments |
| BE777601A BE777601R (en) | 1971-12-31 | 1971-12-31 | N-disubstd-amino-ethyl esters of vincaminic acid - - prepd by transesterification of vincamine or from epi-16-vincamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1382608A true GB1382608A (en) | 1975-02-05 |
Family
ID=25656949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4771872A Expired GB1382608A (en) | 1971-10-25 | 1972-10-17 | Vincaminic acid derivatives and their preparation |
Country Status (3)
| Country | Link |
|---|---|
| FR (1) | FR2157944B1 (en) |
| GB (1) | GB1382608A (en) |
| HU (1) | HU165974B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1448712A (en) * | 1962-07-11 | 1966-03-18 | Process for the preparation of naked-disubstituted aminoethyl esters of reserpilinic and isoreserpilinic acids and novel esters of this type | |
| FR1592869A (en) * | 1968-11-22 | 1970-05-19 |
-
1972
- 1972-10-17 GB GB4771872A patent/GB1382608A/en not_active Expired
- 1972-10-25 HU HUOI000157 patent/HU165974B/hu unknown
- 1972-10-25 FR FR7237773A patent/FR2157944B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2157944A1 (en) | 1973-06-08 |
| FR2157944B1 (en) | 1976-04-23 |
| HU165974B (en) | 1974-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |