GB1380089A - 2-aryl-1,3-indandiones - Google Patents

2-aryl-1,3-indandiones

Info

Publication number
GB1380089A
GB1380089A GB275872A GB275872A GB1380089A GB 1380089 A GB1380089 A GB 1380089A GB 275872 A GB275872 A GB 275872A GB 275872 A GB275872 A GB 275872A GB 1380089 A GB1380089 A GB 1380089A
Authority
GB
United Kingdom
Prior art keywords
compounds
halogen
reacting
indandiones
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB275872A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Gentili SpA
Original Assignee
Istituto Gentili SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Gentili SpA filed Critical Istituto Gentili SpA
Priority to GB275872A priority Critical patent/GB1380089A/en
Publication of GB1380089A publication Critical patent/GB1380089A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75—Reactions with formaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1380089 2-aryl-1,3-indandiones ISTITUTO GENTILI-PISA SpA 20 Jan 1972 2758/72 Heading C2C The invention comprises compounds of formula wherein R is H, halogen, CH 2 OH or alkyl; Ar is Ph, 1 or 2 naphthyl, or m-anisyl, -halophenyl, -tolyl or -trifluoromethylphenyl; and X is 4- or 5- halogen, alkyl, CF 3 , CO 2 H, OH, NH 2 , NO 2 or OCOR<SP>11</SP> where R<SP>11</SP> is Me, Et, CF 3 , Ph or PhCH 2 . In examples, these compounds are prepared by (1) reacting an X-substituted phthalic acid or anhydride with ArCH 2 CO 2 H in presence of Ac 2 O and Et 3 N (for R=H); (2) reacting I (R = H) with Br 2 or CH 2 O (for R=Br or OH 2 OH, respectively); or (3) hydrolysing I (X=OAc), to give I(X=OH). Therapeutic compositions comprise compounds of the above formula, and are stated to have antiinflammatory, analgesic, antitussive, uricosuri and (in certain cases) anticoagulant activity.
GB275872A 1972-01-20 1972-01-20 2-aryl-1,3-indandiones Expired GB1380089A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB275872A GB1380089A (en) 1972-01-20 1972-01-20 2-aryl-1,3-indandiones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB275872A GB1380089A (en) 1972-01-20 1972-01-20 2-aryl-1,3-indandiones

Publications (1)

Publication Number Publication Date
GB1380089A true GB1380089A (en) 1975-01-08

Family

ID=9745341

Family Applications (1)

Application Number Title Priority Date Filing Date
GB275872A Expired GB1380089A (en) 1972-01-20 1972-01-20 2-aryl-1,3-indandiones

Country Status (1)

Country Link
GB (1) GB1380089A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008540A2 (en) * 1978-08-24 1980-03-05 Union Carbide Corporation 2-aryl-1,3-indandione derivatives and compositions comprising them for controlling ectoparasitic acarina
EP0138272A1 (en) * 1983-10-14 1985-04-24 Akzo N.V. Diarylindane-1,3-diones, their preparation and use
EP0398258A1 (en) * 1989-05-16 1990-11-22 Mitsubishi Kasei Corporation Indan-1,3-dione derivative and herbicidal composition containing the same as active ingredient
WO1998055439A1 (en) * 1997-06-05 1998-12-10 Venantius Limited Indane compounds and their pharmaceutical use

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008540A2 (en) * 1978-08-24 1980-03-05 Union Carbide Corporation 2-aryl-1,3-indandione derivatives and compositions comprising them for controlling ectoparasitic acarina
EP0008540B1 (en) * 1978-08-24 1984-10-24 Union Carbide Corporation 2-aryl-1,3-indandione derivatives and compositions comprising them for controlling ectoparasitic acarina
EP0138272A1 (en) * 1983-10-14 1985-04-24 Akzo N.V. Diarylindane-1,3-diones, their preparation and use
EP0398258A1 (en) * 1989-05-16 1990-11-22 Mitsubishi Kasei Corporation Indan-1,3-dione derivative and herbicidal composition containing the same as active ingredient
US5076830A (en) * 1989-05-16 1991-12-31 Mitsubishi Kasei Corporation Indan-1,3-dione derivative and herbicidal composition containing the same as active ingredient
US5110342A (en) * 1989-05-16 1992-05-05 Mitsubishi Kasei Corporation Indan-1,3-dione derivative and herbicidal composition containing the same as active ingredient
WO1998055439A1 (en) * 1997-06-05 1998-12-10 Venantius Limited Indane compounds and their pharmaceutical use
US6433021B1 (en) 1997-06-05 2002-08-13 Venantius Limited Indane compounds and their pharmaceutical use

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee