GB1368699A - Benzoyl ureas and process for their manufacture - Google Patents
Benzoyl ureas and process for their manufactureInfo
- Publication number
- GB1368699A GB1368699A GB2956372A GB2956372A GB1368699A GB 1368699 A GB1368699 A GB 1368699A GB 2956372 A GB2956372 A GB 2956372A GB 2956372 A GB2956372 A GB 2956372A GB 1368699 A GB1368699 A GB 1368699A
- Authority
- GB
- United Kingdom
- Prior art keywords
- urea
- substituted
- benzoyl
- tolyl
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008047 benzoylureas Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000004202 carbamide Substances 0.000 abstract 3
- -1 carbamoyl halide Chemical class 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 235000013877 carbamide Nutrition 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- DQMWMUMCNOJLSI-UHFFFAOYSA-N n-carbamothioylbenzamide Chemical compound NC(=S)NC(=O)C1=CC=CC=C1 DQMWMUMCNOJLSI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000001088 1-naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- HRYILSDLIGTCOP-UHFFFAOYSA-N N-benzoylurea Chemical class NC(=O)NC(=O)C1=CC=CC=C1 HRYILSDLIGTCOP-UHFFFAOYSA-N 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000003936 benzamides Chemical class 0.000 abstract 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- UZVCMSJXPBDVPA-UHFFFAOYSA-N benzenecarbonothioylurea Chemical class NC(=O)NC(=S)C1=CC=CC=C1 UZVCMSJXPBDVPA-UHFFFAOYSA-N 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract 1
- LURYMYITPCOQAU-UHFFFAOYSA-N benzoyl isocyanate Chemical class O=C=NC(=O)C1=CC=CC=C1 LURYMYITPCOQAU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 229910003439 heavy metal oxide Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- FKEGBQHLLVYTEQ-UHFFFAOYSA-N n-(iminomethylidene)benzamide Chemical class N=C=NC(=O)C1=CC=CC=C1 FKEGBQHLLVYTEQ-UHFFFAOYSA-N 0.000 abstract 1
- IZQHUTVTROTDOZ-UHFFFAOYSA-N n-carbamothioylbenzenecarbothioamide Chemical class NC(=S)NC(=S)C1=CC=CC=C1 IZQHUTVTROTDOZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712131034 DE2131034A1 (de) | 1971-06-23 | 1971-06-23 | Acylharnstoffe und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1368699A true GB1368699A (en) | 1974-10-02 |
Family
ID=5811500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2956372A Expired GB1368699A (en) | 1971-06-23 | 1972-06-23 | Benzoyl ureas and process for their manufacture |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3823144A (enExample) |
| AR (2) | AR194692A1 (enExample) |
| AU (1) | AU461846B2 (enExample) |
| BE (1) | BE785378A (enExample) |
| DD (1) | DD101401A5 (enExample) |
| DE (1) | DE2131034A1 (enExample) |
| FR (1) | FR2143361B1 (enExample) |
| GB (1) | GB1368699A (enExample) |
| HU (1) | HU165554B (enExample) |
| IL (1) | IL39727A0 (enExample) |
| NL (1) | NL7208259A (enExample) |
| ZA (1) | ZA724294B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES472295A1 (es) * | 1978-08-02 | 1979-02-16 | Invest Tecnica Aplicada | Procedimiento de obtencion de nuevas acilureas con actividadfarmacologica |
| HU184062B (en) * | 1979-10-19 | 1984-06-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing substituted acyl urea |
| US4666911A (en) * | 1981-07-14 | 1987-05-19 | Taiho Pharmaceutical Company Limited | Allophanoylpiperazine compound and analgesic composition containing same as active ingredient |
| US4529819A (en) * | 1982-08-02 | 1985-07-16 | The Dow Chemical Company | Method for making benzoylphenylureas |
| GB8500615D0 (en) * | 1985-01-10 | 1985-02-13 | Lundbeck & Co As H | Organic compounds |
| HUT48093A (en) * | 1986-08-04 | 1989-05-29 | Sandoz Ag | Herbicides comprising benzohydroxamic acid or benzoic acid hydrazide derivatives as active ingredient and process for producing benzohydroxamic acid or benzoic acid hydrazide derivatives |
| US6962926B2 (en) * | 2001-01-31 | 2005-11-08 | Telik, Inc. | Antagonist of MCP-1 function, and compositions and methods of use thereof |
| US6670364B2 (en) * | 2001-01-31 | 2003-12-30 | Telik, Inc. | Antagonists of MCP-1 function and methods of use thereof |
| TWI245761B (en) | 2001-03-01 | 2005-12-21 | Telik Inc | Antagonists of MCP-1 function and methods of use thereof |
| TWI236474B (en) * | 2001-04-03 | 2005-07-21 | Telik Inc | Antagonists of MCP-1 function and methods of use thereof |
-
1971
- 1971-06-23 DE DE19712131034 patent/DE2131034A1/de active Pending
-
1972
- 1972-06-06 DD DD163472A patent/DD101401A5/xx unknown
- 1972-06-16 NL NL7208259A patent/NL7208259A/xx unknown
- 1972-06-21 US US00264747A patent/US3823144A/en not_active Expired - Lifetime
- 1972-06-21 AU AU43660/72A patent/AU461846B2/en not_active Expired
- 1972-06-21 IL IL39727A patent/IL39727A0/xx unknown
- 1972-06-22 ZA ZA724294A patent/ZA724294B/xx unknown
- 1972-06-22 HU HUHO1493A patent/HU165554B/hu unknown
- 1972-06-23 BE BE785378A patent/BE785378A/xx unknown
- 1972-06-23 GB GB2956372A patent/GB1368699A/en not_active Expired
- 1972-06-23 FR FR7222732A patent/FR2143361B1/fr not_active Expired
-
1973
- 1973-06-01 AR AR248363A patent/AR194692A1/es active
- 1973-06-01 AR AR248365A patent/AR194693A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| AU4366072A (en) | 1974-01-03 |
| FR2143361A1 (enExample) | 1973-02-02 |
| AR194692A1 (es) | 1973-07-31 |
| US3823144A (en) | 1974-07-09 |
| ZA724294B (en) | 1973-03-28 |
| AR194693A1 (es) | 1973-07-31 |
| HU165554B (enExample) | 1974-09-28 |
| AU461846B2 (en) | 1975-06-05 |
| IL39727A0 (en) | 1972-08-30 |
| NL7208259A (enExample) | 1972-12-28 |
| FR2143361B1 (enExample) | 1975-06-20 |
| DE2131034A1 (de) | 1973-01-11 |
| BE785378A (fr) | 1972-12-27 |
| DD101401A5 (enExample) | 1973-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |