GB1367674A - 3-fluoroalanines - Google Patents
3-fluoroalaninesInfo
- Publication number
- GB1367674A GB1367674A GB3488671A GB3488671A GB1367674A GB 1367674 A GB1367674 A GB 1367674A GB 3488671 A GB3488671 A GB 3488671A GB 3488671 A GB3488671 A GB 3488671A GB 1367674 A GB1367674 A GB 1367674A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alanine
- fluoro
- deacetylation
- acetylation
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UYTSRQMXRROFPU-REOHCLBHSA-N (2r)-2-amino-3-fluoropropanoic acid Chemical class FC[C@H](N)C(O)=O UYTSRQMXRROFPU-REOHCLBHSA-N 0.000 title abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
- 238000006640 acetylation reaction Methods 0.000 abstract 2
- 238000013375 chromatographic separation Methods 0.000 abstract 2
- 230000006196 deacetylation Effects 0.000 abstract 2
- 238000003381 deacetylation reaction Methods 0.000 abstract 2
- 229910052805 deuterium Inorganic materials 0.000 abstract 2
- UYTSRQMXRROFPU-UHFFFAOYSA-N 2-azaniumyl-3-fluoropropanoate Chemical compound FCC(N)C(O)=O UYTSRQMXRROFPU-UHFFFAOYSA-N 0.000 abstract 1
- 108010041525 Alanine racemase Proteins 0.000 abstract 1
- 125000000030 D-alanine group Chemical group [H]N([H])[C@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 1
- 150000008541 D-alanines Chemical class 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- 229960003767 alanine Drugs 0.000 abstract 1
- 150000001294 alanine derivatives Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/38—Polysiloxanes modified by chemical after-treatment
- C08G77/382—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
- C08G77/385—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
- C07C53/21—Acids containing three or more carbon atoms containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6064570A | 1970-08-03 | 1970-08-03 | |
| US14981471A | 1971-06-03 | 1971-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1367674A true GB1367674A (en) | 1974-09-18 |
Family
ID=26740157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3488671A Expired GB1367674A (en) | 1970-08-03 | 1971-07-26 | 3-fluoroalanines |
Country Status (13)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985004395A1 (en) * | 1984-03-23 | 1985-10-10 | Commonwealth Scientific And Industrial Research Or | Deuterated compounds |
| WO2007109080A3 (en) * | 2006-03-16 | 2007-11-15 | Vertex Pharma | Deuterated hepatitis c protease inhibitors |
| EP2295401A3 (en) * | 2006-03-16 | 2012-07-25 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis C protease inhibitors |
| RU2465264C2 (ru) * | 2006-03-16 | 2012-10-27 | Вертекс Фармасьютикалз Инкорпорейтед | Дейтерированные ингибиторы протеазы гепатита с |
-
1971
- 1971-07-19 NL NLAANVRAGE7109947,A patent/NL174248C/xx not_active IP Right Cessation
- 1971-07-19 DE DE2136067A patent/DE2136067C3/de not_active Expired
- 1971-07-20 AU AU31464/71A patent/AU468229B2/en not_active Expired
- 1971-07-21 CA CA118,804A patent/CA956646A/en not_active Expired
- 1971-07-22 IT IT51834/71A patent/IT1061753B/it active
- 1971-07-26 GB GB3488671A patent/GB1367674A/en not_active Expired
- 1971-08-03 CH CH1140771A patent/CH563961A5/xx not_active IP Right Cessation
- 1971-08-03 IL IL37429A patent/IL37429A/xx unknown
- 1971-08-03 BE BE770888A patent/BE770888A/xx not_active IP Right Cessation
- 1971-08-03 JP JP5802771A patent/JPS565217B1/ja active Pending
- 1971-08-03 IE IE984/71A patent/IE35489B1/xx unknown
- 1971-08-03 FR FR7128394A patent/FR2101198B1/fr not_active Expired
-
1979
- 1979-12-20 HK HK863/79A patent/HK86379A/xx unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985004395A1 (en) * | 1984-03-23 | 1985-10-10 | Commonwealth Scientific And Industrial Research Or | Deuterated compounds |
| WO2007109080A3 (en) * | 2006-03-16 | 2007-11-15 | Vertex Pharma | Deuterated hepatitis c protease inhibitors |
| EP2295401A3 (en) * | 2006-03-16 | 2012-07-25 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis C protease inhibitors |
| US8247532B2 (en) | 2006-03-16 | 2012-08-21 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis C protease inhibitors |
| RU2465264C2 (ru) * | 2006-03-16 | 2012-10-27 | Вертекс Фармасьютикалз Инкорпорейтед | Дейтерированные ингибиторы протеазы гепатита с |
| AU2007227544B2 (en) * | 2006-03-16 | 2012-11-01 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis C protease inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2101198B1 (enrdf_load_stackoverflow) | 1975-08-01 |
| JPS565217B1 (enrdf_load_stackoverflow) | 1981-02-04 |
| BE770888A (fr) | 1972-02-03 |
| NL174248C (nl) | 1984-05-16 |
| HK86379A (en) | 1979-12-28 |
| IE35489L (en) | 1972-02-03 |
| DE2136067C3 (de) | 1980-09-11 |
| CH563961A5 (enrdf_load_stackoverflow) | 1975-07-15 |
| AU3146471A (en) | 1973-01-25 |
| IE35489B1 (en) | 1976-03-03 |
| IL37429A (en) | 1975-05-22 |
| FR2101198A1 (enrdf_load_stackoverflow) | 1972-03-31 |
| AU468229B2 (en) | 1976-01-08 |
| NL7109947A (enrdf_load_stackoverflow) | 1972-02-07 |
| DE2136067B2 (de) | 1980-01-17 |
| IL37429A0 (en) | 1971-11-29 |
| DE2136067A1 (de) | 1972-02-10 |
| IT1061753B (it) | 1983-04-30 |
| CA956646A (en) | 1974-10-22 |
| NL174248B (nl) | 1983-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |