GB1366098A - Antibacterial agents - Google Patents
Antibacterial agentsInfo
- Publication number
- GB1366098A GB1366098A GB4261371A GB4261371A GB1366098A GB 1366098 A GB1366098 A GB 1366098A GB 4261371 A GB4261371 A GB 4261371A GB 4261371 A GB4261371 A GB 4261371A GB 1366098 A GB1366098 A GB 1366098A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- salt
- compound
- group
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1366098 7 - [D - (α - Amino - α - phenylacetamido)]-3-substituted cephalosporins BRISTOLMYERS CO 13 Sept 1971 [14 Sept 1970 (2) 23 Nov 1970] 42613/71 Heading C2A The invention comprises compounds which have the Formula I wherein A is a group of formula or having the D-configuration in the side chain, and the pharmaceutically acceptable salts thereof. A process for the preparation of these compounds comprises reacting a compound of Formula II or a salt or ester thereof with an acid having the Formula III wherein B represents a blocking group or its functional equivalent as an acylating agent for a primary amino group, and thereafter removing the blocking group. Suitable blocking groups include t-butoxy-carbonyl, carbobenzyloxy, 2- hydroxy-1-naphthcarbonyl and trichloroethoxycarbonyl (removable by formic acid, catalytic hydrogenation, acid hydrolysis and zinc dust in glacial acetic acid respectively). A pharmaceutical composition comprises a compound of Formula I above or salt thereof, together with a carrier or excipient. A method of treating mammals other than human beings, to cure them of diseases caused by Gram-positive or Gram-negative bacteria comprises administering to the mammal an effective amount of a compound of Formula I or a salt thereof or the above-mentioned pharmaceutical composition.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7217370A | 1970-09-14 | 1970-09-14 | |
US7217270A | 1970-09-14 | 1970-09-14 | |
US9218870A | 1970-11-23 | 1970-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1366098A true GB1366098A (en) | 1974-09-11 |
Family
ID=27372031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4261371A Expired GB1366098A (en) | 1970-09-14 | 1971-09-13 | Antibacterial agents |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS523948B1 (en) |
BE (1) | BE772592A (en) |
CH (1) | CH564025A5 (en) |
DE (1) | DE2145928A1 (en) |
DK (1) | DK138746B (en) |
ES (1) | ES395083A1 (en) |
FR (1) | FR2106501B1 (en) |
GB (1) | GB1366098A (en) |
NL (1) | NL7112483A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1035353A (en) * | 1973-01-31 | 1978-07-25 | Lee C. Cheney | 3-thiolated-7-acylamidocephalosporanic acids |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1930204A1 (en) * | 1968-06-14 | 1970-01-22 | Glaxo Lab Ltd | Cephalosporin compounds and processes for their preparation |
ZA698494B (en) * | 1969-02-26 | 1971-07-28 | Lilly Co Eli | Sulfur-containing cephalosporing antibiotics |
-
1971
- 1971-09-10 NL NL7112483A patent/NL7112483A/xx not_active Application Discontinuation
- 1971-09-13 FR FR7132975A patent/FR2106501B1/fr not_active Expired
- 1971-09-13 CH CH1339271A patent/CH564025A5/xx not_active IP Right Cessation
- 1971-09-13 GB GB4261371A patent/GB1366098A/en not_active Expired
- 1971-09-14 DE DE19712145928 patent/DE2145928A1/en active Pending
- 1971-09-14 DK DK448971A patent/DK138746B/en unknown
- 1971-09-14 BE BE772592A patent/BE772592A/en unknown
- 1971-09-14 ES ES395083A patent/ES395083A1/en not_active Expired
- 1971-09-14 JP JP7098371A patent/JPS523948B1/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2106501B1 (en) | 1975-08-01 |
CH564025A5 (en) | 1975-07-15 |
DE2145928A1 (en) | 1972-03-23 |
NL7112483A (en) | 1972-03-16 |
DK138746C (en) | 1979-03-26 |
BE772592A (en) | 1972-03-14 |
ES395083A1 (en) | 1974-12-16 |
JPS523948B1 (en) | 1977-01-31 |
FR2106501A1 (en) | 1972-05-05 |
DK138746B (en) | 1978-10-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |