GB1363735A - Process for the manufacture of benzimidazolones - Google Patents
Process for the manufacture of benzimidazolonesInfo
- Publication number
- GB1363735A GB1363735A GB4878671A GB4878671A GB1363735A GB 1363735 A GB1363735 A GB 1363735A GB 4878671 A GB4878671 A GB 4878671A GB 4878671 A GB4878671 A GB 4878671A GB 1363735 A GB1363735 A GB 1363735A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzimidazolones
- oct
- alkyl
- general formula
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008641 benzimidazolones Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702052026 DE2052026C3 (de) | 1970-10-23 | Verfahren zur Herstellung von Benzimidazolone) | |
| DE19712131367 DE2131367C3 (de) | 1971-06-24 | 1971-06-24 | Verfahren zur Herstellung von Benzimidazolonen-(2) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1363735A true GB1363735A (en) | 1974-08-14 |
Family
ID=25759948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4878671A Expired GB1363735A (en) | 1970-10-23 | 1971-10-20 | Process for the manufacture of benzimidazolones |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS558974B1 (enrdf_load_stackoverflow) |
| BR (1) | BR7107095D0 (enrdf_load_stackoverflow) |
| CA (1) | CA940933A (enrdf_load_stackoverflow) |
| CH (1) | CH559729A5 (enrdf_load_stackoverflow) |
| FR (1) | FR2113192A5 (enrdf_load_stackoverflow) |
| GB (1) | GB1363735A (enrdf_load_stackoverflow) |
| IT (1) | IT995020B (enrdf_load_stackoverflow) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624186B2 (en) * | 1998-12-04 | 2003-09-23 | Neurosearch A/S | Ion channel modulating agents comprising novel benzimidazolone derivatives |
| US7851465B2 (en) | 2007-03-09 | 2010-12-14 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US7994313B2 (en) | 2005-06-01 | 2011-08-09 | The Regents Of The University Of Michigan | Unsolvated benzodiazepine compositions and methods |
| US8088759B2 (en) | 2005-11-01 | 2012-01-03 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US8097612B2 (en) | 2006-06-09 | 2012-01-17 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US8168626B2 (en) | 1999-04-30 | 2012-05-01 | The Regents Of The University Of Michigan | Benzodiazepine compositions for treating epidermal hyperplasia and related disorders |
| US8188072B2 (en) | 2007-11-06 | 2012-05-29 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
| US8324258B2 (en) | 2007-09-14 | 2012-12-04 | The Regents Of The University Of Michigan | F1F0-ATPase inhibitors and related methods |
| US8415343B2 (en) | 1999-04-30 | 2013-04-09 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting the proliferation of cells |
| US8497307B2 (en) | 2008-09-11 | 2013-07-30 | The Regents Of The University Of Michigan | Aryl guanidine F1F0-ATPase inhibitors and related methods |
| US8604023B2 (en) | 2009-04-17 | 2013-12-10 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| US8673897B2 (en) | 2009-09-18 | 2014-03-18 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
| US8809323B2 (en) | 1999-04-30 | 2014-08-19 | The Regents Of The University Of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| US8815845B2 (en) | 2009-11-17 | 2014-08-26 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| US9126978B2 (en) | 2009-11-17 | 2015-09-08 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ187066A (en) * | 1977-05-03 | 1981-02-11 | Hoffmann La Roche | 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones) |
| DE2855226A1 (de) * | 1978-12-21 | 1980-07-10 | Hoechst Ag | Verfahren zur herstellung von benzimidazolon-(2) |
| JPS57157287A (en) * | 1981-03-24 | 1982-09-28 | Matsushita Electronics Corp | Large scale ic circuit for crt display |
| JPH0361765U (enrdf_load_stackoverflow) * | 1989-10-19 | 1991-06-17 | ||
| EP2935215B1 (en) * | 2012-12-20 | 2019-11-13 | Lu, Qing-Bin | Radiosensitizer compounds for use in combination with radiation |
-
1971
- 1971-10-20 CH CH1525371A patent/CH559729A5/xx not_active IP Right Cessation
- 1971-10-20 GB GB4878671A patent/GB1363735A/en not_active Expired
- 1971-10-21 JP JP8294171A patent/JPS558974B1/ja active Pending
- 1971-10-21 IT IT3018271A patent/IT995020B/it active
- 1971-10-22 CA CA125,839A patent/CA940933A/en not_active Expired
- 1971-10-22 BR BR709571A patent/BR7107095D0/pt unknown
- 1971-10-25 FR FR7138217A patent/FR2113192A5/fr not_active Expired
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624186B2 (en) * | 1998-12-04 | 2003-09-23 | Neurosearch A/S | Ion channel modulating agents comprising novel benzimidazolone derivatives |
| US8722667B2 (en) | 1999-04-30 | 2014-05-13 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting the proliferation of cells |
| US8168626B2 (en) | 1999-04-30 | 2012-05-01 | The Regents Of The University Of Michigan | Benzodiazepine compositions for treating epidermal hyperplasia and related disorders |
| US8809323B2 (en) | 1999-04-30 | 2014-08-19 | The Regents Of The University Of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| US8415343B2 (en) | 1999-04-30 | 2013-04-09 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting the proliferation of cells |
| US7994313B2 (en) | 2005-06-01 | 2011-08-09 | The Regents Of The University Of Michigan | Unsolvated benzodiazepine compositions and methods |
| US8088759B2 (en) | 2005-11-01 | 2012-01-03 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US8791104B2 (en) | 2005-11-01 | 2014-07-29 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US8097612B2 (en) | 2006-06-09 | 2012-01-17 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US7851465B2 (en) | 2007-03-09 | 2010-12-14 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US8242109B2 (en) | 2007-03-09 | 2012-08-14 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| US8324258B2 (en) | 2007-09-14 | 2012-12-04 | The Regents Of The University Of Michigan | F1F0-ATPase inhibitors and related methods |
| US8461153B2 (en) | 2007-11-06 | 2013-06-11 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
| US8759340B2 (en) | 2007-11-06 | 2014-06-24 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
| US8188072B2 (en) | 2007-11-06 | 2012-05-29 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
| US8497307B2 (en) | 2008-09-11 | 2013-07-30 | The Regents Of The University Of Michigan | Aryl guanidine F1F0-ATPase inhibitors and related methods |
| US8604023B2 (en) | 2009-04-17 | 2013-12-10 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| US8673897B2 (en) | 2009-09-18 | 2014-03-18 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
| US8815845B2 (en) | 2009-11-17 | 2014-08-26 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| US9126978B2 (en) | 2009-11-17 | 2015-09-08 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
Also Published As
| Publication number | Publication date |
|---|---|
| CA940933A (en) | 1974-01-29 |
| FR2113192A5 (enrdf_load_stackoverflow) | 1972-06-23 |
| JPS558974B1 (enrdf_load_stackoverflow) | 1980-03-07 |
| CH559729A5 (enrdf_load_stackoverflow) | 1975-03-14 |
| IT995020B (it) | 1975-11-10 |
| BR7107095D0 (pt) | 1973-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1363735A (en) | Process for the manufacture of benzimidazolones | |
| CH549590A (fr) | Procede de preparation de derives d'acides pyrazolo (3,4b)pyridine-5-carboxyliques. | |
| RO63761A (fr) | Procede pour la preparation des derives 0-substitues-d'acide-7-beta-amino-3-cephem 3-ole-4-carboxylique | |
| GB1189720A (en) | Aromatic Sulfamoyl Compounds | |
| DK139625B (da) | Analogifremgangsmåde til fremstilling af cycloalkan(c)pyridazin- eller pyrido(4,3-c)pyridazinderivater eller syreadditionssalte deraf. | |
| YU126573A (en) | Process for preparing new mono - and siesters of 2,5-dihydroxy benzene sulfonic acid | |
| IT1025320B (it) | Procedimento elettrolitico per la fabbricatione contemporanea di soluzioni acquose concentrate e diluite di idrato | |
| GB1448096A (en) | Azo compounds process for their preparation and use | |
| BE781314A (fr) | Procede de production continue d'une solution aqueuse de chlorure de choline | |
| NL167594B (nl) | Werkwijze voor het winnen van het antibioticum av 290 en werkwijze voor het bereiden van een, een anti- bioticum bevattende toeslag voor diervoeder. | |
| RO64918A (ro) | Procedeu pentru prepararea unor derivati ai acizilor pirimido-(4,5-b)-chinolin-4 (3h)-on-2-carboxilici | |
| CH552984A (fr) | Procede de preparation d'une solutionaqueuse stable d'un chelate de doxycycline. | |
| IL43996A (en) | Fungicidal dispersions of 2-methyl-5,6-dihydropyran-3-carboxylic acid anilide | |
| GB1428341A (en) | Process for preparing 4,5-diphenyl-oxazol-2-one | |
| AU458551B2 (en) | Composition of baths for electrodeposition of bright zinc from aqueous, acid, electroplating baths | |
| JPS57112357A (en) | Synthesis of intermediate of antibacterial agent | |
| CH554898A (fr) | Procede de preparation de derives d'acide 2-(thiocarbonylamino)acetamidocephalosporanique. | |
| DK104735C (da) | Fremgangsmåde til fremstilling a quinolinderivater eller syreadditionssalte deraf. | |
| RO76586A (ro) | Procedeu de preparare a unui aditiv pentru insilozarea porumbului | |
| BE755067A (fr) | Dispersions aqueuses de polymerisats, contenant des derives de l'acide p-aminobenzoique | |
| DK137925B (da) | Analogifremgangsmåde til fremstilling 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-forbindelser eller syreadditionssalte deraf. | |
| GB1284051A (en) | Process for the preparation of 3,4-dihydroisoquinoline derivatives | |
| ATE17116T1 (de) | Selektive acylierung von hydroxy-aminoarylsulfons|ure. | |
| GB1429861A (en) | Vincamine derivatives | |
| ZA742452B (en) | A process for the production of a zinc salt of 2-mercaptobenzothiazole or 2-mercaptobenzimidazole |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |