GB1359374A - Cycloaliphatic penicilins - Google Patents
Cycloaliphatic penicilinsInfo
- Publication number
- GB1359374A GB1359374A GB5773071A GB5773071A GB1359374A GB 1359374 A GB1359374 A GB 1359374A GB 5773071 A GB5773071 A GB 5773071A GB 5773071 A GB5773071 A GB 5773071A GB 1359374 A GB1359374 A GB 1359374A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- prepared
- acid
- penicillins
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002960 penicillins Chemical class 0.000 abstract 8
- 229930182555 Penicillin Natural products 0.000 abstract 5
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 4
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 4
- -1 amidinoureido Chemical group 0.000 abstract 4
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 239000011541 reaction mixture Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- JBJJTCGQCRGNOL-SSDOTTSWSA-N (2r)-2-amino-2-cyclohexa-1,4-dien-1-ylacetic acid Chemical compound OC(=O)[C@H](N)C1=CCC=CC1 JBJJTCGQCRGNOL-SSDOTTSWSA-N 0.000 abstract 2
- WAMWSIDTKSNDCU-SSDOTTSWSA-N (2r)-2-azaniumyl-2-cyclohexylacetate Chemical compound OC(=O)[C@H](N)C1CCCCC1 WAMWSIDTKSNDCU-SSDOTTSWSA-N 0.000 abstract 2
- DDYDBBBQYLFRJE-UHFFFAOYSA-N (diaminomethylideneamino)urea Chemical compound NC(=N)NNC(N)=O DDYDBBBQYLFRJE-UHFFFAOYSA-N 0.000 abstract 2
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- GNGGMSVYWXCTEE-UHFFFAOYSA-N (diaminomethylideneamino)urea;dihydrochloride Chemical compound Cl.Cl.NC(=N)NNC(N)=O GNGGMSVYWXCTEE-UHFFFAOYSA-N 0.000 abstract 1
- 230000006181 N-acylation Effects 0.000 abstract 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 150000004684 trihydrates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE101572A IE36576B1 (en) | 1971-08-12 | 1972-07-20 | Novel cycloaliphatic penicillins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17136771A | 1971-08-12 | 1971-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1359374A true GB1359374A (en) | 1974-07-10 |
Family
ID=22623472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5773071A Expired GB1359374A (en) | 1971-08-12 | 1971-12-13 | Cycloaliphatic penicilins |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3741960A (https=) |
| JP (1) | JPS4828492A (https=) |
| BE (1) | BE787420A (https=) |
| CA (1) | CA983479A (https=) |
| CH (1) | CH596219A5 (https=) |
| DE (1) | DE2238474A1 (https=) |
| FR (1) | FR2150780B1 (https=) |
| GB (1) | GB1359374A (https=) |
| NL (1) | NL7210847A (https=) |
| ZA (1) | ZA724733B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3937699A (en) * | 1970-10-12 | 1976-02-10 | Takeda Chemical Industries, Ltd. | 6-(1'-cyclohexenylglycinamido)penicillanic acid and salts thereof |
| US3891627A (en) * | 1972-05-18 | 1975-06-24 | Pfizer | 6-{8 Alpha-(amidinothioacylamido)acylamido{9 penicillanic acids |
| US4005075A (en) * | 1973-04-05 | 1977-01-25 | Sumitomo Chemical Company, Limited | Penicillins and their preparation |
-
0
- BE BE787420D patent/BE787420A/xx unknown
-
1971
- 1971-08-12 US US00171367A patent/US3741960A/en not_active Expired - Lifetime
- 1971-12-13 GB GB5773071A patent/GB1359374A/en not_active Expired
-
1972
- 1972-07-07 CA CA146,618A patent/CA983479A/en not_active Expired
- 1972-07-11 ZA ZA724733A patent/ZA724733B/xx unknown
- 1972-08-04 DE DE2238474A patent/DE2238474A1/de active Pending
- 1972-08-08 NL NL7210847A patent/NL7210847A/xx not_active Application Discontinuation
- 1972-08-09 CH CH1177972A patent/CH596219A5/xx not_active IP Right Cessation
- 1972-08-11 JP JP47080685A patent/JPS4828492A/ja active Pending
- 1972-08-11 FR FR7229232A patent/FR2150780B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE787420A (fr) | 1973-02-12 |
| FR2150780A1 (https=) | 1973-04-13 |
| CH596219A5 (https=) | 1978-03-15 |
| FR2150780B1 (https=) | 1976-04-16 |
| US3741960A (en) | 1973-06-26 |
| ZA724733B (en) | 1974-02-27 |
| NL7210847A (https=) | 1973-02-14 |
| AU4443372A (en) | 1974-01-17 |
| CA983479A (en) | 1976-02-10 |
| JPS4828492A (https=) | 1973-04-14 |
| DE2238474A1 (de) | 1973-02-15 |
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| Publication | Publication Date | Title |
|---|---|---|
| GB1470188A (en) | Penicillins | |
| GB1359374A (en) | Cycloaliphatic penicilins | |
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| EP1075479A1 (en) | A method for crystallizing a beta-lactam antibiotic | |
| GB1490289A (en) | Intermediates and production thereof for use in the preparation of 6-(2-phenyl-2-(guanylureidoacetamido)acetamido)penicillanic acid | |
| US3206455A (en) | Process for producing 6-(alpha-aminoacylamino)-penicillanic acids | |
| IL42087A (en) | The preparation of 7-aminocephalosporanic acid derivative | |
| US3094519A (en) | Process for the preparation of derivatives of 6-amino-penicillanic acid | |
| US4024129A (en) | Process for the preparation of heterocyclic compounds | |
| US3453263A (en) | Method of preparing penicillins | |
| US3576855A (en) | N-chloroformyl-n-phenylglycine,intermediate for preparing penicillins | |
| US3813389A (en) | Process for 7-aminocephalosporanic acid | |
| US3989688A (en) | Process for producing 6-amino penicillanic acid derivatives | |
| US3574799A (en) | Thiazolylpenicillins and their preparation | |
| US3682981A (en) | 2-amino-2-(1,4-cyclohexadienyl) acetic acid | |
| US3749711A (en) | Acylaminopenicillanic acids and salts thereof | |
| US3538083A (en) | Synthetic method for preparing penicillins | |
| JPS6131113B2 (https=) | ||
| CA1058162A (en) | Process for producing 6-aminopenicillanic acid derivatives | |
| US3188311A (en) | Process for the preparation of 7-amino-cephalosporanic acids | |
| SU471723A3 (ru) | Способ получени производных пенициллина |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |