GB1356911A - Purification and fractionation of carcinoembryonic antigen - Google Patents
Purification and fractionation of carcinoembryonic antigenInfo
- Publication number
- GB1356911A GB1356911A GB1830971*[A GB1830971A GB1356911A GB 1356911 A GB1356911 A GB 1356911A GB 1830971 A GB1830971 A GB 1830971A GB 1356911 A GB1356911 A GB 1356911A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- carcinoembryonic antigen
- fractions
- june
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 title abstract 4
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title abstract 2
- 238000005194 fractionation Methods 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 4
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 abstract 2
- 239000005695 Ammonium acetate Substances 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 229940043376 ammonium acetate Drugs 0.000 abstract 2
- 235000019257 ammonium acetate Nutrition 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- JVIPLYCGEZUBIO-UHFFFAOYSA-N 2-(4-fluorophenyl)-1,3-dioxoisoindole-5-carboxylic acid Chemical compound O=C1C2=CC(C(=O)O)=CC=C2C(=O)N1C1=CC=C(F)C=C1 JVIPLYCGEZUBIO-UHFFFAOYSA-N 0.000 abstract 1
- 229920000936 Agarose Polymers 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 229920001425 Diethylaminoethyl cellulose Polymers 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 101000588258 Taenia solium Paramyosin Proteins 0.000 abstract 1
- 208000009956 adenocarcinoma Diseases 0.000 abstract 1
- 239000011543 agarose gel Substances 0.000 abstract 1
- 239000012062 aqueous buffer Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000005352 clarification Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/02—Column or bed processes
- B01J47/04—Mixed-bed processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57473—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen, i.e. CEA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
1356911 Purification and functionation of carcinoembryonic antigen F HOFFMANN-LA ROCHE & CO AG 1 June 1971 [1 June 1970 27 Jan 1971 12 April 1971] 18309/71 Heading A5B A purified human carcinoembryonic antigen is prepared by a process comprising: a) homogenizing adenocarcinoma tissue; b) removing solid from the homogenisate; c) treating the supernatant with a glycoprotein solvent (e.g. perchloric acid); d) discarding the precipitate and clarifying the solution; c) subjecting the clarified solution to osmosis against an aqueous solution of a polyethylene glycol which has a M.W. of approx. 15,000 to 20,000 and a softening point of about 60C; f) dissolving the resulting rentate in an aqueous buffer of pH 5-9; g) chromatographing the solution from f) sequentially on two different gel columns, the one being an agarose gel comprising approximately 6% agarose and having a particle size of 40-210 microns and the other being a water-insoluble, cross-linked, hydrophilic, dextran polymer gel; h) collecting the fractions having a spectrophotometric adsorption peak of 280mÁ and a M.W. of about 200,000 to about 500,000. These fractions may be combined and subjected to further treatment to produce two different active compounds, namely "Human carcinoembryonic antigen A and B". Suitable treatment comprises osmosis against a polyethylene glycol solution as described above, dissolution in a buffer, e.g. ammonium acetate at pH4, clarification and chromatography on a mixed bed ion-exchange column comprising microgranular diethylaminoethyl cellulose and carboxymethyl cellulose, using e.g. ammonium acetate/sodium chloride (pH 4) as eluant.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4252670A | 1970-06-01 | 1970-06-01 | |
| US11028871A | 1971-01-27 | 1971-01-27 | |
| US13340471A | 1971-04-12 | 1971-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1356911A true GB1356911A (en) | 1974-06-19 |
Family
ID=27366145
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4418473A Expired GB1356912A (en) | 1970-06-01 | 1971-06-01 | Radioiodinated derivatives of carcinoembryonic antigen materials and processes for the production thereof |
| GB1830971*[A Expired GB1356911A (en) | 1970-06-01 | 1971-06-01 | Purification and fractionation of carcinoembryonic antigen |
| GB4418773A Expired GB1358828A (en) | 1970-06-01 | 1971-06-01 | Process for detecting the presence of human carcinoembryonic antigen material or component a or b thereof in blood |
| GB4418573A Expired GB1358827A (en) | 1970-06-01 | 1971-06-01 | Process for detecting the presence of human carcinoembryonic antigen material in blood |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4418473A Expired GB1356912A (en) | 1970-06-01 | 1971-06-01 | Radioiodinated derivatives of carcinoembryonic antigen materials and processes for the production thereof |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4418773A Expired GB1358828A (en) | 1970-06-01 | 1971-06-01 | Process for detecting the presence of human carcinoembryonic antigen material or component a or b thereof in blood |
| GB4418573A Expired GB1358827A (en) | 1970-06-01 | 1971-06-01 | Process for detecting the presence of human carcinoembryonic antigen material in blood |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3697638A (en) |
| JP (1) | JPS542247B1 (en) |
| BE (1) | BE767801A (en) |
| CA (1) | CA965351A (en) |
| CH (4) | CH596554A5 (en) |
| DE (1) | DE2126680B2 (en) |
| DK (1) | DK132739C (en) |
| FR (1) | FR2095644A5 (en) |
| GB (4) | GB1356912A (en) |
| IL (1) | IL36950A (en) |
| IT (1) | IT998033B (en) |
| NL (1) | NL161457C (en) |
| SE (5) | SE400083B (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3867363A (en) * | 1970-06-01 | 1975-02-18 | Hans John Hansen | Carcinoembryonic antigens |
| CH583036A5 (en) * | 1972-05-12 | 1976-12-31 | Hoffmann La Roche | |
| US3956258A (en) * | 1972-05-12 | 1976-05-11 | Hoffmann-La Roche Inc. | Carcinoembryonic antigens |
| ZA723264B (en) * | 1972-10-13 | 1974-08-28 | H Van Til | Improvements in toys |
| US3867518A (en) * | 1973-03-09 | 1975-02-18 | Hoffmann La Roche | Radioimmunoassay for insulin |
| US3927193A (en) * | 1973-05-18 | 1975-12-16 | Hoffmann La Roche | Localization of tumors by radiolabelled antibodies |
| US4022876A (en) * | 1973-06-21 | 1977-05-10 | Stanford Research Institute | Mass spectrometric immunoassay |
| US4132769A (en) * | 1974-10-30 | 1979-01-02 | Osther Kurt B | Cancer antigen, cancer therapy, and cancer diagnosis |
| US4152410A (en) * | 1975-09-03 | 1979-05-01 | Eisai Co., Ltd. | Diagnosis reagent for neoplasm and method for diagnosis of neoplasm |
| US4132767A (en) * | 1976-04-05 | 1979-01-02 | Eisai Co., Ltd. | Preparation of α-L antibody, purification of α-L antigen and reagent for detection of α-L antibody and α-L antigen |
| US4144031A (en) * | 1976-04-19 | 1979-03-13 | International Radioimmune Systems, Inc. | Cell test for detecting human chorionic gonadotropin |
| US4145336A (en) * | 1976-04-30 | 1979-03-20 | Scripps Clinic And Research Foundation | Carcinoembryonic antigen isomer |
| US4140753A (en) * | 1976-04-30 | 1979-02-20 | Scripps Clinic & Research Foundation | Diagnostic method and reagent |
| US4146603A (en) * | 1977-02-18 | 1979-03-27 | Research Corporation | Tumor specific glycoproteins and method for detecting tumorigenic cancers |
| US4234476A (en) * | 1978-03-07 | 1980-11-18 | Research Corporation | Application of protein-protein interaction as an assay for the detection of cancer |
| US4228127A (en) * | 1978-10-06 | 1980-10-14 | International Radioimmune Systems, Inc. | Kit for detecting human chorionic gonadotropin |
| US4241044A (en) * | 1978-12-28 | 1980-12-23 | Abbott Laboratories | Method of diagnosing cancer by detecting elevated anti-T antibody activity |
| US4349528A (en) * | 1979-11-21 | 1982-09-14 | The Wistar Institute | Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen |
| US4299815A (en) * | 1980-02-08 | 1981-11-10 | Hoffmann-La Roche Inc. | Carcinoembryonic antigen determination |
| US4578349A (en) * | 1982-04-08 | 1986-03-25 | Abbott Laboratories | Immunoassay for carcinoembryonic antigen (CEA) |
| ATE28937T1 (en) * | 1982-08-09 | 1987-08-15 | Centocor Inc | IMMUNOTEST FOR CARBOHYDRATE ANTIGEN DETERMINANT. |
| DK557483A (en) * | 1982-12-06 | 1984-06-07 | Hoffmann La Roche | METHOD OF DETERMINING CEA |
| US4962187A (en) * | 1984-11-28 | 1990-10-09 | Cota Biotech | Common antigen for colorectal and mucinous ovarian tumors and process for isolating the same |
| US5030559A (en) * | 1986-04-01 | 1991-07-09 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification of metastatic human tumors |
| US6013772A (en) * | 1986-08-13 | 2000-01-11 | Bayer Corporation | Antibody preparations specifically binding to unique determinants of CEA antigens or fragments thereof and use of the antibody preparations in immunoassays |
| US5217903A (en) * | 1990-05-15 | 1993-06-08 | Trustees Of Boston University | Measuring connective tissue breakdown products in body fluids |
-
1971
- 1971-04-12 US US133404A patent/US3697638A/en not_active Expired - Lifetime
- 1971-05-19 CH CH737871A patent/CH596554A5/xx not_active IP Right Cessation
- 1971-05-26 FR FR7119009A patent/FR2095644A5/fr not_active Expired
- 1971-05-28 DK DK260171A patent/DK132739C/en not_active IP Right Cessation
- 1971-05-28 IL IL36950A patent/IL36950A/en unknown
- 1971-05-28 BE BE767801A patent/BE767801A/en not_active IP Right Cessation
- 1971-05-28 SE SE7106985A patent/SE400083B/en unknown
- 1971-05-28 DE DE2126680A patent/DE2126680B2/en not_active Ceased
- 1971-05-29 IT IT25226/71A patent/IT998033B/en active
- 1971-06-01 GB GB4418473A patent/GB1356912A/en not_active Expired
- 1971-06-01 GB GB1830971*[A patent/GB1356911A/en not_active Expired
- 1971-06-01 NL NL7107499.A patent/NL161457C/en not_active IP Right Cessation
- 1971-06-01 GB GB4418773A patent/GB1358828A/en not_active Expired
- 1971-06-01 GB GB4418573A patent/GB1358827A/en not_active Expired
- 1971-06-01 JP JP3751971A patent/JPS542247B1/ja active Pending
- 1971-06-01 CA CA114,457A patent/CA965351A/en not_active Expired
-
1974
- 1974-10-18 SE SE7413186A patent/SE397139B/en unknown
- 1974-10-18 SE SE7413187A patent/SE419482B/en unknown
- 1974-10-18 SE SE7413184A patent/SE421425B/en unknown
- 1974-10-18 SE SE7413185A patent/SE419481B/en unknown
-
1977
- 1977-01-24 CH CH81877A patent/CH595636A5/xx not_active IP Right Cessation
- 1977-01-24 CH CH81777A patent/CH606067A5/xx not_active IP Right Cessation
- 1977-01-24 CH CH81977A patent/CH604665A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL161457C (en) | 1980-02-15 |
| FR2095644A5 (en) | 1972-02-11 |
| SE397139B (en) | 1977-10-17 |
| US3697638A (en) | 1972-10-10 |
| IL36950A0 (en) | 1971-11-29 |
| SE7413187L (en) | 1974-10-18 |
| SE419482B (en) | 1981-08-03 |
| SE7413184L (en) | 1974-10-18 |
| SE421425B (en) | 1981-12-21 |
| SE400083B (en) | 1978-03-13 |
| SE419481B (en) | 1981-08-03 |
| DK132739C (en) | 1976-07-12 |
| IL36950A (en) | 1975-04-25 |
| DE2126680B2 (en) | 1980-10-09 |
| BE767801A (en) | 1971-11-29 |
| CH595636A5 (en) | 1978-02-15 |
| JPS542247B1 (en) | 1979-02-05 |
| CH606067A5 (en) | 1978-10-13 |
| GB1356912A (en) | 1974-06-19 |
| CH604665A5 (en) | 1978-09-15 |
| NL161457B (en) | 1979-09-17 |
| DE2126680A1 (en) | 1971-12-09 |
| SE7413186L (en) | 1974-10-18 |
| GB1358828A (en) | 1974-07-03 |
| IT998033B (en) | 1976-01-20 |
| CA965351A (en) | 1975-04-01 |
| CH596554A5 (en) | 1978-03-15 |
| DK132739B (en) | 1976-02-02 |
| NL7107499A (en) | 1971-12-03 |
| GB1358827A (en) | 1974-07-03 |
| SE7413185L (en) | 1974-10-18 |
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