GB1356346A - Immunological reagents - Google Patents

Immunological reagents

Info

Publication number
GB1356346A
GB1356346A GB1711871A GB1711871A GB1356346A GB 1356346 A GB1356346 A GB 1356346A GB 1711871 A GB1711871 A GB 1711871A GB 1711871 A GB1711871 A GB 1711871A GB 1356346 A GB1356346 A GB 1356346A
Authority
GB
United Kingdom
Prior art keywords
sheep
gamma globulin
reagin
labelled
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1711871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of GB1356346A publication Critical patent/GB1356346A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1356346 Immunological testing PHARMACIA AB 26 May 1971 [27 May 1970] 17118/71 Heading G1B A reagent-combination for use in carrying out tests on samples of human origin utilizing an immunological reaction between an antigen (1) and an antibody (2), one of which is of ovine or bovine origin comprises either antigen (1) or antibody (2), and non-human animal gamma globulin (3) for reaction with heterophile antibodies present in the sample under test, the non-human animal gamma globulin (3) being contained separately from (1) or (2) or being mixed with (1) or (2). The antigen (1) or antibody (2) may be chemically or physically bound to carrier particles (for example co-polymers of dextran and epichlorhydrin, or to microcrystalline cellulose or cellulose in the form of a paper disc or to a tube of plastics material) and may be radio-actively labelled or labelled with colour producing atom or group, for example with fluorescein. The non-human gamma globulin (3) may be horse, sheep or bovine. Examples relate to determination of reagin-Ig directed against cow epithelium where the reagents are allergen bound to dextranepichlorhydrin co-polymer resin treated with cyanogen bromide or to microcrystalline cellulose, sheep anti-reagin epsilon fragments, I<125> labelled reagin, with bovine serum to provide component (3); determination of reagin-Ig directed against horse epithelium using allergen bound to cross-linked dextran substituted with isothiocyanotophenoxyhydroxypropyl groups and sheep anti-reagin Fc fragments labelled with I<125>, with horse or sheep gamma globulin as component (3); pregnancy tests using latex particles coated with sheep anti-HCG and bovine or sheep gamma globulin as component (3); determination of IgE using sheep-anti IgE bound to dextran-epichlorhydrin copolymer resin treated with cyanogen bromide, and IgE labelled with I<125>, with sheep gamma globulin as component (3).
GB1711871A 1970-05-27 1971-05-26 Immunological reagents Expired GB1356346A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE727070 1970-05-27

Publications (1)

Publication Number Publication Date
GB1356346A true GB1356346A (en) 1974-06-12

Family

ID=20270914

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1711871A Expired GB1356346A (en) 1970-05-27 1971-05-26 Immunological reagents

Country Status (6)

Country Link
AU (1) AU2919171A (en)
CH (1) CH538692A (en)
DE (1) DE2126128A1 (en)
FR (1) FR2093840A5 (en)
GB (1) GB1356346A (en)
NL (1) NL7107245A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289748A (en) * 1979-05-31 1981-09-15 United States Of America Ultrasensitive enzymatic radioimmunoassay method
WO1990010226A1 (en) * 1989-02-21 1990-09-07 Pitman-Moore, Inc. Preventing false-positive results in elisa-assay methods
GB2496122A (en) * 2011-10-31 2013-05-08 Ge Healthcare Bio Sciences Ab Biological sample preservation on paper
US11266337B2 (en) 2015-09-09 2022-03-08 Drawbridge Health, Inc. Systems, methods, and devices for sample collection, stabilization and preservation

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4170454A (en) * 1978-03-30 1979-10-09 Union Carbide Corporation Process for the preparation of a solid-phase radioimmunoassay support and use thereof
JPS60256057A (en) * 1984-06-01 1985-12-17 Dai Ichi Pure Chem Co Ltd Immunological measurement
DE3715333A1 (en) * 1987-05-08 1988-11-24 Behringwerke Ag METHOD FOR THE QUANTITATIVE DETERMINATION OF SERUM PROTEINS IN BODY LIQUIDS, AND MEANS FOR IMPLEMENTING THE METHOD

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289748A (en) * 1979-05-31 1981-09-15 United States Of America Ultrasensitive enzymatic radioimmunoassay method
WO1990010226A1 (en) * 1989-02-21 1990-09-07 Pitman-Moore, Inc. Preventing false-positive results in elisa-assay methods
GB2496122A (en) * 2011-10-31 2013-05-08 Ge Healthcare Bio Sciences Ab Biological sample preservation on paper
US10371608B2 (en) 2011-10-31 2019-08-06 Ge Healthcare Bio-Sciences Ab Sample preservation method and sample preservation substrate
US11266337B2 (en) 2015-09-09 2022-03-08 Drawbridge Health, Inc. Systems, methods, and devices for sample collection, stabilization and preservation

Also Published As

Publication number Publication date
FR2093840A5 (en) 1972-01-28
DE2126128A1 (en) 1971-12-09
NL7107245A (en) 1971-11-30
CH538692A (en) 1973-06-30
AU2919171A (en) 1972-11-30

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees