GB1354554A - 2-substituted benzimidazoles - Google Patents
2-substituted benzimidazolesInfo
- Publication number
- GB1354554A GB1354554A GB3966271A GB3966271A GB1354554A GB 1354554 A GB1354554 A GB 1354554A GB 3966271 A GB3966271 A GB 3966271A GB 3966271 A GB3966271 A GB 3966271A GB 1354554 A GB1354554 A GB 1354554A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- phenoxy
- condensing
- aug
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2-substituted benzimidazoles Chemical class 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 241000287433 Turdus Species 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6854970A | 1970-08-31 | 1970-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1354554A true GB1354554A (en) | 1974-06-05 |
Family
ID=22083267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3966271A Expired GB1354554A (en) | 1970-08-31 | 1971-08-24 | 2-substituted benzimidazoles |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU448887B2 (cg-RX-API-DMAC10.html) |
| DE (1) | DE2143614A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2103639B1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB1354554A (cg-RX-API-DMAC10.html) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000073300A1 (en) * | 1999-06-02 | 2000-12-07 | Warner-Lambert Company | Amino heterocycles useful as pharmaceutical agents |
| WO2003066622A1 (en) * | 2002-02-06 | 2003-08-14 | Isis, Pharmaceuticals | Novel benzimidazole compounds |
| US6939877B2 (en) | 2002-09-12 | 2005-09-06 | Wyeth | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans |
| US7550603B2 (en) | 2005-04-11 | 2009-06-23 | Abbott Laboratories Inc. | 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors |
| US7595406B2 (en) | 2005-11-15 | 2009-09-29 | Abbott Laboratories Inc. | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors |
| US7642265B2 (en) | 2002-12-03 | 2010-01-05 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antivirals |
| US7728026B2 (en) | 2005-04-11 | 2010-06-01 | Abbott Laboratories, Inc. | 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors |
| US7781596B1 (en) | 1998-11-03 | 2010-08-24 | Abbott Laboratories | Substituted 2-phenylbenzimidazoles, the production thereof and their use |
| US7999117B2 (en) | 2006-05-02 | 2011-08-16 | Abbott Lab | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors |
| US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
| US8093396B2 (en) | 2009-01-19 | 2012-01-10 | Abbott Laboratories | Benzthiazole inhibitors of poly(ADP-ribose)polymerase |
| CN103896915A (zh) * | 2014-04-01 | 2014-07-02 | 中国药科大学 | 苯并咪唑类衍生物、其制备方法及其在医药上的应用 |
-
1971
- 1971-08-24 GB GB3966271A patent/GB1354554A/en not_active Expired
- 1971-08-25 AU AU32713/71A patent/AU448887B2/en not_active Expired
- 1971-08-30 FR FR7131355A patent/FR2103639B1/fr not_active Expired
- 1971-08-31 DE DE2143614A patent/DE2143614A1/de active Pending
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7781596B1 (en) | 1998-11-03 | 2010-08-24 | Abbott Laboratories | Substituted 2-phenylbenzimidazoles, the production thereof and their use |
| WO2000073300A1 (en) * | 1999-06-02 | 2000-12-07 | Warner-Lambert Company | Amino heterocycles useful as pharmaceutical agents |
| US6436974B1 (en) | 1999-06-02 | 2002-08-20 | Warner-Lambert Company | Amino heterocycles useful as pharmaceutical agents |
| WO2003066622A1 (en) * | 2002-02-06 | 2003-08-14 | Isis, Pharmaceuticals | Novel benzimidazole compounds |
| US7244847B2 (en) * | 2002-02-06 | 2007-07-17 | Isis Pharmaceuticals, Inc. | Benzimidazole compounds |
| US6939877B2 (en) | 2002-09-12 | 2005-09-06 | Wyeth | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans |
| US7479500B2 (en) | 2002-09-12 | 2009-01-20 | Wyeth | Antidepressant piperidine derivatives of heterocyclefused benzodioxans |
| US7642265B2 (en) | 2002-12-03 | 2010-01-05 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antivirals |
| US8207173B2 (en) | 2002-12-03 | 2012-06-26 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antivirals |
| US7728026B2 (en) | 2005-04-11 | 2010-06-01 | Abbott Laboratories, Inc. | 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors |
| US7550603B2 (en) | 2005-04-11 | 2009-06-23 | Abbott Laboratories Inc. | 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors |
| US8217070B2 (en) | 2005-04-11 | 2012-07-10 | Abbott Laboratories | 2-substituted-1H-benzimidazole-4-carboxamides are PARP inhibitors |
| US7595406B2 (en) | 2005-11-15 | 2009-09-29 | Abbott Laboratories Inc. | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors |
| US7999117B2 (en) | 2006-05-02 | 2011-08-16 | Abbott Lab | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors |
| US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
| US8093396B2 (en) | 2009-01-19 | 2012-01-10 | Abbott Laboratories | Benzthiazole inhibitors of poly(ADP-ribose)polymerase |
| CN103896915A (zh) * | 2014-04-01 | 2014-07-02 | 中国药科大学 | 苯并咪唑类衍生物、其制备方法及其在医药上的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2103639B1 (cg-RX-API-DMAC10.html) | 1975-08-01 |
| AU448887B2 (en) | 1974-05-30 |
| FR2103639A1 (cg-RX-API-DMAC10.html) | 1972-04-14 |
| DE2143614A1 (de) | 1973-04-05 |
| AU3271371A (en) | 1973-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |