GB1353331A - Process for preparing halobenzoic acids - Google Patents

Process for preparing halobenzoic acids

Info

Publication number
GB1353331A
GB1353331A GB1107771A GB1107771A GB1353331A GB 1353331 A GB1353331 A GB 1353331A GB 1107771 A GB1107771 A GB 1107771A GB 1107771 A GB1107771 A GB 1107771A GB 1353331 A GB1353331 A GB 1353331A
Authority
GB
United Kingdom
Prior art keywords
general formula
group
alkoxy
alkenyloxy
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1107771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3474770A external-priority patent/JPS5525182B1/ja
Priority claimed from JP3474870A external-priority patent/JPS5010573B1/ja
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to GB3340771A priority Critical patent/GB1353332A/en
Publication of GB1353331A publication Critical patent/GB1353331A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

1353331 5 - Halo - 4 - amino - 2 - (alkoxy or alkenyloxy) benzole acids and their derivatives TEIKOKU HORMONE MFG CO Ltd 23 April 1971 [24 April 1970 (2)] 11077/71 Heading C2C 5 - Halo - 4 - amino - 2 - (alkoxy or alkenyloxy)-benzoic acids of the general formula wherein A is an alkyl or alkenyl group and X is a halogen atom, are prepared by reaction of a 4-amino-2-(alkoxy or alkenyloxy)-benzoic acid of the general formula with an N-halo acid amide or imide; and may then be converted to N-(dialkylaminoalkyl)-5- halo-4-amino-2-(alkoxy or alkenyloxy)-benzamides of the general formula wherein R 2 is an alkylene group and each of R 3 and R 4 is an alkyl group, and acid addition salts thereof by (a) reaction with a haloformic acid ester of the general formula XCOOR 1 , wherein R 1 is an alkyl, alkenyl or aralkyl group, followed by a dialkylaminoalkylamine of the general formula H 2 NR 2 NR 3 R 4 ; (b) reaction with a heterocyclic compound of the general formula wherein each of R 5 , R 6 , R, and R 8 is a nitrogen atom or a CH group, at least two of them in each ring being CH groups, G is a sulphur or carbon atom and X is an oxygen or sulphur atom, G being a carbon atom when Z is a sulphur atom, followed by a dialkylaminoalkylamine of the fifth general formula above; and (c) reaction with a compound of the general formula R 13 R 14 P-N(R 12 )-R 2 NR 3 R 4 , wherein each of R 13 and R 14 is an alkoxy or phenoxy group, or a group of formula -N(R 12 )-R 2 NR 3 R 4 or -N(R 2 NR 3 R 4 )-P[N(R 12 )R 2 NR 3 R 4 ] 2 , or R 13 and R 14 together form an alkylenedioxy or ophenylenedioxy group, and R 12 is a hydrogen atom, or R 12 and R 13 together form a P-N bond; followed optionally by salification of the product.
GB1107771A 1970-04-24 1971-04-23 Process for preparing halobenzoic acids Expired GB1353331A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3340771A GB1353332A (en) 1970-04-24 1971-04-23 Phosphorus derivatives of n-substituted alkylene diamines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3474770A JPS5525182B1 (en) 1970-04-24 1970-04-24
JP3474870A JPS5010573B1 (en) 1970-04-24 1970-04-24

Publications (1)

Publication Number Publication Date
GB1353331A true GB1353331A (en) 1974-05-15

Family

ID=26373595

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1107771A Expired GB1353331A (en) 1970-04-24 1971-04-23 Process for preparing halobenzoic acids

Country Status (4)

Country Link
CA (1) CA945564A (en)
DE (1) DE2119724B2 (en)
FR (1) FR2093454A5 (en)
GB (1) GB1353331A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010108A (en) * 1988-03-17 1991-04-23 Poli Industria Chimica S.P.A. N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations
WO2005023808A2 (en) * 2003-09-09 2005-03-17 Alizyme Therapeutics Limited Process for the preparation of renzapride and intermediates thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1068726B (en) * 1976-11-24 1985-03-21 Rotta Research Lab QUATERNARY AMMONIC DERIVATIVES OF L ADAMANTAN FOR ANTI-MICROBIAL ACTIVITY

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010108A (en) * 1988-03-17 1991-04-23 Poli Industria Chimica S.P.A. N-cycloalkylaminoethylbenzamide derivatives, their synthesis and pharmaceutical preparations
WO2005023808A2 (en) * 2003-09-09 2005-03-17 Alizyme Therapeutics Limited Process for the preparation of renzapride and intermediates thereof
WO2005023808A3 (en) * 2003-09-09 2005-07-07 Alizyme Therapeutics Ltd Process for the preparation of renzapride and intermediates thereof
US7189852B2 (en) 2003-09-09 2007-03-13 Alizyme Therapeutics Limited Synthesis

Also Published As

Publication number Publication date
CA945564A (en) 1974-04-16
DE2119724B2 (en) 1976-04-29
DE2119724A1 (en) 1971-12-30
FR2093454A5 (en) 1972-01-28

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee