GB1351396A - N-substituted derivatives of 4,-n-piperazinylmethyl spiro dibenzo cycloheptadior triene 5,2-dioxolane-1,3, their method of preparation and their application in therapeutics - Google Patents
N-substituted derivatives of 4,-n-piperazinylmethyl spiro dibenzo cycloheptadior triene 5,2-dioxolane-1,3, their method of preparation and their application in therapeuticsInfo
- Publication number
- GB1351396A GB1351396A GB2752572A GB2752572A GB1351396A GB 1351396 A GB1351396 A GB 1351396A GB 2752572 A GB2752572 A GB 2752572A GB 2752572 A GB2752572 A GB 2752572A GB 1351396 A GB1351396 A GB 1351396A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- piperazinylmethyl
- dioxolane
- group
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- 125000003003 spiro group Chemical group 0.000 title 1
- 150000005671 trienes Chemical class 0.000 title 1
- -1 Piperazinylmethyl Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
- 206010038678 Respiratory depression Diseases 0.000 abstract 1
- 229910021627 Tin(IV) chloride Inorganic materials 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- GKIPXFAANLTWBM-UHFFFAOYSA-N epibromohydrin Chemical compound BrCC1CO1 GKIPXFAANLTWBM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000029 gastro-duodenal ulcer Toxicity 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 abstract 1
- 230000009278 visceral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7122226A FR2141600B1 (enrdf_load_stackoverflow) | 1971-06-18 | 1971-06-18 | |
| FR7224158A FR2190435B2 (enrdf_load_stackoverflow) | 1971-06-18 | 1972-07-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1351396A true GB1351396A (en) | 1974-04-24 |
Family
ID=26216463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2752572A Expired GB1351396A (en) | 1971-06-18 | 1972-06-13 | N-substituted derivatives of 4,-n-piperazinylmethyl spiro dibenzo cycloheptadior triene 5,2-dioxolane-1,3, their method of preparation and their application in therapeutics |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE784724A (enrdf_load_stackoverflow) |
| CA (1) | CA991172A (enrdf_load_stackoverflow) |
| CH (1) | CH544112A (enrdf_load_stackoverflow) |
| DE (1) | DE2229507C3 (enrdf_load_stackoverflow) |
| FR (2) | FR2141600B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1351396A (enrdf_load_stackoverflow) |
| LU (1) | LU65503A1 (enrdf_load_stackoverflow) |
| NL (1) | NL166021C (enrdf_load_stackoverflow) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH522632A (fr) * | 1970-04-15 | 1972-06-30 | Delalande Sa | Procédé de préparation de nouveaux dérivés de l'amino-méthyl-4'-spiro(dibenzo(a-d)cycloheptadi-(ou tri-)ène-5 : 2'- dioxolane (1',3')) |
-
1971
- 1971-06-18 FR FR7122226A patent/FR2141600B1/fr not_active Expired
-
1972
- 1972-06-12 BE BE784724A patent/BE784724A/xx unknown
- 1972-06-13 GB GB2752572A patent/GB1351396A/en not_active Expired
- 1972-06-13 LU LU65503D patent/LU65503A1/xx unknown
- 1972-06-16 CH CH903772A patent/CH544112A/fr not_active IP Right Cessation
- 1972-06-16 CA CA144,978A patent/CA991172A/fr not_active Expired
- 1972-06-16 DE DE19722229507 patent/DE2229507C3/de not_active Expired
- 1972-06-19 NL NL7208370A patent/NL166021C/xx not_active IP Right Cessation
- 1972-07-04 FR FR7224158A patent/FR2190435B2/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2190435A2 (enrdf_load_stackoverflow) | 1974-02-01 |
| BE784724A (fr) | 1972-12-12 |
| DE2229507A1 (de) | 1973-01-04 |
| FR2190435B2 (enrdf_load_stackoverflow) | 1975-06-20 |
| LU65503A1 (enrdf_load_stackoverflow) | 1973-01-22 |
| NL166021C (nl) | 1981-06-15 |
| NL166021B (nl) | 1981-01-15 |
| DE2229507B2 (de) | 1977-09-08 |
| FR2141600A1 (enrdf_load_stackoverflow) | 1973-01-26 |
| NL7208370A (enrdf_load_stackoverflow) | 1972-12-20 |
| FR2141600B1 (enrdf_load_stackoverflow) | 1974-09-27 |
| CA991172A (fr) | 1976-06-15 |
| DE2229507C3 (de) | 1978-05-11 |
| CH544112A (fr) | 1973-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |