GB1348642A - Hypocholesterolaemic compositions - Google Patents
Hypocholesterolaemic compositionsInfo
- Publication number
- GB1348642A GB1348642A GB4914070A GB1348642DA GB1348642A GB 1348642 A GB1348642 A GB 1348642A GB 4914070 A GB4914070 A GB 4914070A GB 1348642D A GB1348642D A GB 1348642DA GB 1348642 A GB1348642 A GB 1348642A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ether
- alkyl
- methyl
- group
- hypocholesterolaemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000000871 hypocholesterolemic effect Effects 0.000 title abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract 2
- -1 α-naphthyl Chemical group 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- DEWLEGDTCGBNGU-UHFFFAOYSA-N 1,3-dichloropropan-2-ol Chemical compound ClCC(O)CCl DEWLEGDTCGBNGU-UHFFFAOYSA-N 0.000 abstract 1
- HHHGHRABZLIUAT-UHFFFAOYSA-N 2-(4-ethylphenoxy)-2-methylpropanoic acid Chemical compound CCC1=CC=C(OC(C)(C)C(O)=O)C=C1 HHHGHRABZLIUAT-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 229920002873 Polyethylenimine Polymers 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 159000000013 aluminium salts Chemical class 0.000 abstract 1
- 229910000329 aluminium sulfate Inorganic materials 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical group 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- TXCGAZHTZHNUAI-UHFFFAOYSA-N clofibric acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 TXCGAZHTZHNUAI-UHFFFAOYSA-N 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 239000003094 microcapsule Substances 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000012053 oil suspension Substances 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229960003080 taurine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4914070 | 1970-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1348642A true GB1348642A (en) | 1974-03-20 |
Family
ID=10451313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4914070A Expired GB1348642A (en) | 1970-10-15 | 1970-10-15 | Hypocholesterolaemic compositions |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3846541A (enExample) |
| AU (1) | AU458705B2 (enExample) |
| CA (1) | CA968272A (enExample) |
| DE (1) | DE2151510A1 (enExample) |
| FR (1) | FR2110458B1 (enExample) |
| GB (1) | GB1348642A (enExample) |
| SE (1) | SE402709B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069306A (en) * | 1974-03-14 | 1978-01-17 | Pharmacia Aktiebolag | X-ray contrast preparation containing a hydrophilic polymer containing amino groups |
| FR2382892A1 (fr) * | 1977-03-08 | 1978-10-06 | Sarget Lab | Nouveau medicament hypolipidemiant a base d'ester de p-chlorophenol de l'acide p-chlorophenoxyisobutyrique |
| IT1106718B (it) | 1978-12-21 | 1985-11-18 | Alfa Farmaceutici Spa | Composizioni a base di resine anioniche salificate farmacologicamente attive |
| US4393145A (en) * | 1979-05-01 | 1983-07-12 | Etablissement Texcontor | Anionic ion exchange resins with cholesterol-decreasing properties |
| US4788055A (en) * | 1985-12-09 | 1988-11-29 | Ciba-Geigy Corporation | Resinate sustained release dextromethorphan composition |
| EP0276807A3 (en) * | 1987-01-27 | 1988-10-12 | Warner-Lambert Company | Lipid regulating compositions |
| US5167965A (en) * | 1987-02-09 | 1992-12-01 | The Dow Chemical Company | Palatable cholestyramine granules, tablets and methods for preparation thereof |
| IL85632A (en) * | 1987-03-10 | 1991-08-16 | Ciba Geigy Ag | Hypocholesterolaemic gel formulation containing a pharmaceutically acceptable non-digestible anion exchange resin |
| US4837255A (en) * | 1987-03-10 | 1989-06-06 | Ciba-Geigy Corporation | Palatable hypocholesterolaemic gel formulation containing a pharmaceutically acceptable non-digestible anion exchange resin |
| US4859703A (en) * | 1987-06-15 | 1989-08-22 | Warner-Lambert Company | Lipid regulating compositions |
| US5520932A (en) * | 1988-06-24 | 1996-05-28 | The Upjohn Company | Fine-milled colestipol hydrochloride |
| IL95574A (en) * | 1989-09-09 | 1994-11-11 | Knoll Ag | Colestyramine preparation |
| US20050090553A1 (en) * | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
| US8178516B2 (en) * | 1992-06-30 | 2012-05-15 | Sylvan Labs, LLC | Compositions and method for treatment of chronic inflammatory diseases |
| US5451397A (en) * | 1992-12-21 | 1995-09-19 | Rohm And Haas Company | Bile acid sequestrant |
| US5498678A (en) * | 1992-12-21 | 1996-03-12 | Rohm And Haas Company | Suspension polymerization process for water-soluble monomers |
| US7071174B1 (en) * | 1994-10-13 | 2006-07-04 | Cv Therapeutics, Inc. | Method and composition for inhibiting cholesterol esterase |
| JP5889321B2 (ja) | 2010-11-04 | 2016-03-22 | アルビレオ アクチエボラグ | 肝疾患の処置用のｉｂａｔ阻害剤 |
| WO2012064267A1 (en) | 2010-11-08 | 2012-05-18 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| CA2842802C (en) * | 2011-08-01 | 2020-03-10 | Hb Biotechnologies Corporation | Non-digestible capsules for the delivery of fluid absorbing materials |
| WO2013063512A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| MX363161B (es) | 2011-10-28 | 2019-03-13 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica. |
| EP2968230A2 (en) | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| MX2015013196A (es) | 2013-03-15 | 2016-04-15 | Lumena Pharmaceuticals Inc | Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett. |
| PT3923943T (pt) | 2019-02-12 | 2024-10-23 | Mirum Pharmaceuticals Inc | Resposta dependente da dose e do genótipo a um asbti em doentes com deficiência na bomba de exportação de sais biliares |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB860303A (en) * | 1958-06-20 | 1961-02-01 | Ici Ltd | Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª |
| US3042667A (en) * | 1959-03-10 | 1962-07-03 | Pharmacia Ab | Process for producing dextran derivatives and products resulting therefrom |
| NL252506A (enExample) * | 1959-06-12 | |||
| US3383281A (en) * | 1961-09-22 | 1968-05-14 | Merck & Co Inc | Method for binding bile acids in vivo |
| US3308020A (en) * | 1961-09-22 | 1967-03-07 | Merck & Co Inc | Compositions and method for binding bile acids in vivo including hypocholesteremics |
| US3627872A (en) * | 1968-04-08 | 1971-12-14 | Upjohn Co | Oral treatment of hyper-cholesteremia in mammals and birds with ether-type anion exchangers of polysaccharides |
-
1970
- 1970-10-15 GB GB4914070A patent/GB1348642A/en not_active Expired
-
1971
- 1971-10-13 AU AU34513/71A patent/AU458705B2/en not_active Expired
- 1971-10-13 CA CA125,078A patent/CA968272A/en not_active Expired
- 1971-10-14 SE SE7113008A patent/SE402709B/xx unknown
- 1971-10-15 FR FR7137143A patent/FR2110458B1/fr not_active Expired
- 1971-10-15 DE DE19712151510 patent/DE2151510A1/de active Pending
-
1973
- 1973-03-20 US US00343182A patent/US3846541A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SE402709B (sv) | 1978-07-17 |
| DE2151510A1 (de) | 1972-04-20 |
| US3846541A (en) | 1974-11-05 |
| FR2110458B1 (enExample) | 1975-02-07 |
| AU458705B2 (en) | 1975-03-06 |
| FR2110458A1 (enExample) | 1972-06-02 |
| CA968272A (en) | 1975-05-27 |
| AU3451371A (en) | 1973-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1348642A (en) | Hypocholesterolaemic compositions | |
| DE3362784D1 (en) | Process for preparing free-flowing ethylcellulose microcapsules | |
| ZA827284B (en) | Carboxylic acid derivatives | |
| GB1427112A (en) | Antifouling compositions | |
| ES8507444A1 (es) | Un procedimiento para la preparacion de un derivado de un alcohol , -dihidropoliprenilico | |
| GB1495733A (en) | Pharmaceutical preparations | |
| JPS51149247A (en) | Prostaglandin analogues, process for their preparation and drug compos itions containing them as effective ingredients | |
| DE3363550D1 (en) | New nitro aliphatic compounds, process for preparation thereof and use thereof | |
| GB1471406A (en) | Detergent composition | |
| SE7708553L (sv) | Antibakteriell munvardskomposition | |
| GB1238597A (enExample) | ||
| SE7404515L (enExample) | ||
| ES543792A0 (es) | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias | |
| ES441775A1 (es) | Procedimiento para preparar colorantes antraquinonicos solu-bles en agua. | |
| IE831232L (en) | Iodophor compositions | |
| JPS5225740A (en) | Preparation of o-acyl-amidinophenols or acid addition salts thereof | |
| ES397453A1 (es) | Procedimiento para la preparacion de derivados de imidazo- lina. | |
| GB959993A (en) | Camphor derivatives | |
| GB1341204A (en) | Process for the manufacture of triarylmethane compounds | |
| ZA793425B (en) | Substituted 2-phenylamino-2-imidazolines and acid addition salts thereof,processes for their preparation,and pharmaceutical compositions containing these compounds | |
| IE41226L (en) | Benzylamines; pharmaceutical compositions | |
| CA1034491A (en) | Inhibiting discoloration of aqueous compositions containing hexamethylenetetramine 1,3-dichloropropene salts | |
| GB1452455A (en) | Thionophosphoric -phosphonic- acid esters and their use as insecticides and acaricides | |
| GB1034789A (en) | Improvements in or relating to novel trisubstituted acrylic acid derivatives | |
| GB966485A (en) | ª‡-hydroxy-aliphatic carboxylic acids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] |