GB1348162A - Decyl esters of prostaglandin e1 and e2 and production thereof - Google Patents
Decyl esters of prostaglandin e1 and e2 and production thereofInfo
- Publication number
- GB1348162A GB1348162A GB2685071A GB2685071A GB1348162A GB 1348162 A GB1348162 A GB 1348162A GB 2685071 A GB2685071 A GB 2685071A GB 2685071 A GB2685071 A GB 2685071A GB 1348162 A GB1348162 A GB 1348162A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prostaglandin
- esters
- decyl esters
- production
- pge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 title abstract 4
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 title abstract 3
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000711 alprostadil Drugs 0.000 title abstract 2
- 229960002986 dinoprostone Drugs 0.000 title abstract 2
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 title abstract 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 title 1
- DVGVUEKIOAHHSC-UHFFFAOYSA-N (1z)-1-diazodecane Chemical compound CCCCCCCCCC=[N+]=[N-] DVGVUEKIOAHHSC-UHFFFAOYSA-N 0.000 abstract 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 210000004051 gastric juice Anatomy 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
Abstract
1348162 Decyl esters of PGE 1 and PGE 2 ONO PHARMACEUTICAL CO Ltd 19 April 1971 [15 April 1970 (2)] 26850/71 Heading C2C Novel decyl esters of prostaglandin E 1 and E 2 are obtained by reacting the free acids with diazodecane. Pharmaceutical compositions suitable for oral or parenteral administration, contain the above novel esters and suitable carriers or diluents. The compounds possess the ability to inhibit gastric juice secretion. Reference has been directed by the Comptroller to Specifications 851,827 and 1,040,544.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3219070A JPS5114505B1 (en) | 1970-04-15 | 1970-04-15 | |
| JP3219170 | 1970-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1348162A true GB1348162A (en) | 1974-03-13 |
Family
ID=26370724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2685071A Expired GB1348162A (en) | 1970-04-15 | 1971-04-19 | Decyl esters of prostaglandin e1 and e2 and production thereof |
Country Status (11)
| Country | Link |
|---|---|
| BE (1) | BE765732A (en) |
| CH (1) | CH560666A5 (en) |
| DE (1) | DE2118242C3 (en) |
| DK (1) | DK126319B (en) |
| ES (1) | ES390065A1 (en) |
| FR (1) | FR2092047B1 (en) |
| GB (1) | GB1348162A (en) |
| HU (1) | HU163602B (en) |
| NL (1) | NL7104974A (en) |
| NO (1) | NO131931C (en) |
| SE (1) | SE374353B (en) |
-
1971
- 1971-04-02 NO NO128071A patent/NO131931C/no unknown
- 1971-04-08 ES ES390065A patent/ES390065A1/en not_active Expired
- 1971-04-14 NL NL7104974A patent/NL7104974A/xx unknown
- 1971-04-14 CH CH534371A patent/CH560666A5/xx not_active IP Right Cessation
- 1971-04-14 BE BE765732A patent/BE765732A/en unknown
- 1971-04-14 DK DK177071A patent/DK126319B/en unknown
- 1971-04-15 DE DE19712118242 patent/DE2118242C3/en not_active Expired
- 1971-04-15 FR FR7113322A patent/FR2092047B1/fr not_active Expired
- 1971-04-15 HU HUOO000170 patent/HU163602B/hu unknown
- 1971-04-15 SE SE492071A patent/SE374353B/xx unknown
- 1971-04-19 GB GB2685071A patent/GB1348162A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7104974A (en) | 1971-10-19 |
| SE374353B (en) | 1975-03-03 |
| DE2118242B2 (en) | 1973-05-10 |
| FR2092047B1 (en) | 1974-05-24 |
| DE2118242C3 (en) | 1973-12-13 |
| DE2118242A1 (en) | 1971-10-28 |
| NO131931B (en) | 1975-05-20 |
| BE765732A (en) | 1971-08-30 |
| CH560666A5 (en) | 1975-04-15 |
| HU163602B (en) | 1973-09-27 |
| ES390065A1 (en) | 1974-06-01 |
| FR2092047A1 (en) | 1972-01-21 |
| NO131931C (en) | 1975-08-27 |
| DK126319B (en) | 1973-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |