GB1343213A - Piperdyl-furanones - Google Patents

Piperdyl-furanones

Info

Publication number
GB1343213A
GB1343213A GB2438471*A GB2438471A GB1343213A GB 1343213 A GB1343213 A GB 1343213A GB 2438471 A GB2438471 A GB 2438471A GB 1343213 A GB1343213 A GB 1343213A
Authority
GB
United Kingdom
Prior art keywords
dihydro
hydroxy
oxobutyl
piperidyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2438471*A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1343213A publication Critical patent/GB1343213A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1343213 3-[1-(4-Phenyl-4-oxobutyl)-4-hydroxy- 4 - piperidyl] - dihydro - 2(3 H ) - furanones SANDOZ Ltd 19 April 1971 [20 March 1970 2 Sept 1970] 24384/71 Heading C2C Novel 3-[1-(4-phenyl-4-oxobutyl)-4-hydroxy- 4-pyridyl]-dihydro-2(3H)-furanones of the general formula wherein R 1 is a hydrogen atom or C 1-3 alkyl group and R 2 is a hydrogen, fluorine, chlorine or bromine atom and acid addition salts thereof are prepared by condensing a dihydro-4-(4- hydroxy-4-piperidyl)-2(3H)-furanone and a butyrophenone derivative of the respective general formulµ wherein X is the acid radical of a reactive ester, in the presence of an acid-binding agent, followed optionally by salification of a resulting free base or conversion of a resulting salt to the free base. Pharmaceutical compositions having analgesic activity comprise, as active ingredient, a 3-[1-(4- phenyl - 4 - oxobutyl) - 4 - hydroxy - 4 - piperidyl]-dihydro-2(3H)-furanone of the first general formula above or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutical carrier or diluent.
GB2438471*A 1970-03-20 1971-04-19 Piperdyl-furanones Expired GB1343213A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH425970A CH527843A (en) 1970-03-20 1970-03-20 Process for the production of new furanone derivatives

Publications (1)

Publication Number Publication Date
GB1343213A true GB1343213A (en) 1974-01-10

Family

ID=4272780

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2438471*A Expired GB1343213A (en) 1970-03-20 1971-04-19 Piperdyl-furanones

Country Status (5)

Country Link
AT (1) AT317197B (en)
CH (1) CH527843A (en)
CS (1) CS159275B2 (en)
GB (1) GB1343213A (en)
HU (1) HU162861B (en)

Also Published As

Publication number Publication date
CH527843A (en) 1972-09-15
AT317197B (en) 1974-08-12
CS159275B2 (en) 1974-12-27
HU162861B (en) 1973-04-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees