GB1342272A - 3-amino-cardenolides and process for their manufacture - Google Patents
3-amino-cardenolides and process for their manufactureInfo
- Publication number
- GB1342272A GB1342272A GB2467671*A GB2467671A GB1342272A GB 1342272 A GB1342272 A GB 1342272A GB 2467671 A GB2467671 A GB 2467671A GB 1342272 A GB1342272 A GB 1342272A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- cardenolides
- amino
- double bond
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RXUHKPOBBNOXCX-YQGQCKGGSA-N 3-[(8R,9S,10S,13S,14R,17S)-3-amino-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one Chemical class NC1CC2CC[C@@H]3[C@H](CC[C@@]4(C)[C@@H]3CC[C@@H]4C=3COC(=O)C=3)[C@]2(CC1)C RXUHKPOBBNOXCX-YQGQCKGGSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 101100241859 Mus musculus Oacyl gene Proteins 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000001800 adrenalinergic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2013032A DE2013032C3 (de) | 1970-03-19 | 1970-03-19 | 3-Amino-cardenolide, Verfahren zu ihrer Herstellung sowie deren Verwendung bei der Bekämpfung von Herz- und Kreislauf-Krankheiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1342272A true GB1342272A (en) | 1974-01-03 |
Family
ID=5765522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2467671*A Expired GB1342272A (en) | 1970-03-19 | 1971-04-19 | 3-amino-cardenolides and process for their manufacture |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3879379A (enExample) |
| AT (1) | AT306260B (enExample) |
| BE (1) | BE764456A (enExample) |
| CA (1) | CA930728A (enExample) |
| CH (1) | CH553772A (enExample) |
| DE (1) | DE2013032C3 (enExample) |
| FR (1) | FR2085722B1 (enExample) |
| GB (1) | GB1342272A (enExample) |
| NL (1) | NL7103337A (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2415641A1 (fr) * | 1978-01-27 | 1979-08-24 | Nativelle Sa Ets | Amino-3-cardenolides, procede pour leur preparation, et medicaments les contenant |
| FR2415640A1 (fr) * | 1978-01-27 | 1979-08-24 | Nativelle Sa Ets | Derives d'amino-3-cardenolides, procede pour leur preparation, et medicaments les contenant |
| MX2008008608A (es) * | 2006-01-09 | 2009-03-04 | Btg Int Ltd | Moduladores de factor i inducible por hipoxia y usos relacionados. |
| ES2857626T3 (es) | 2010-01-15 | 2021-09-29 | Suzhou Neupharma Co Ltd | Ciertas entidades químicas, composiciones y métodos |
| EP2670763B1 (en) | 2011-02-02 | 2018-08-01 | Suzhou Neupharma Co., Ltd | Certain chemical entities, compositions, and methods |
| WO2013165924A1 (en) | 2012-04-29 | 2013-11-07 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3198792A (en) * | 1962-06-12 | 1965-08-03 | Philips Corp | 10alpha methyl, 9beta hormonal steroids |
| US3272799A (en) * | 1962-10-25 | 1966-09-13 | Smith Kline French Lab | 11, 19-substituted progesterones |
-
1970
- 1970-03-19 DE DE2013032A patent/DE2013032C3/de not_active Expired
-
1971
- 1971-03-12 NL NL7103337A patent/NL7103337A/xx unknown
- 1971-03-16 CH CH387771A patent/CH553772A/xx not_active IP Right Cessation
- 1971-03-17 US US125425A patent/US3879379A/en not_active Expired - Lifetime
- 1971-03-18 CA CA108061A patent/CA930728A/en not_active Expired
- 1971-03-18 BE BE764456A patent/BE764456A/xx unknown
- 1971-03-18 AT AT235071A patent/AT306260B/de not_active IP Right Cessation
- 1971-03-19 FR FR7109713A patent/FR2085722B1/fr not_active Expired
- 1971-04-19 GB GB2467671*A patent/GB1342272A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA930728A (en) | 1973-07-24 |
| FR2085722A1 (enExample) | 1971-12-31 |
| NL7103337A (enExample) | 1971-09-21 |
| BE764456A (fr) | 1971-09-20 |
| FR2085722B1 (enExample) | 1974-05-24 |
| DE2013032C3 (de) | 1978-12-07 |
| CH553772A (de) | 1974-09-13 |
| AT306260B (de) | 1973-04-10 |
| US3879379A (en) | 1975-04-22 |
| DE2013032B2 (de) | 1978-04-20 |
| DE2013032A1 (de) | 1971-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |