GB1334732A - Laminated tablets and process for their preparation - Google Patents

Laminated tablets and process for their preparation

Info

Publication number
GB1334732A
GB1334732A GB44871A GB44871A GB1334732A GB 1334732 A GB1334732 A GB 1334732A GB 44871 A GB44871 A GB 44871A GB 44871 A GB44871 A GB 44871A GB 1334732 A GB1334732 A GB 1334732A
Authority
GB
United Kingdom
Prior art keywords
layers
medicament
silica gel
core
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of GB1334732A publication Critical patent/GB1334732A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1334732 Coated tablets SCHERICO Ltd 5 Jan 1971 [6 Jan 1970] 448/71 Heading A5B A pharmaceutical tablet comprises a core surrounded by layers containing medicament and between two medicament layers a layer comprising 10-50 weight % of silica gel having an average pore diameter of 90-400 Angstroms. The medicament layers may be surrounded by further outer coating layers. Similar porous silica gel layers may be present between the core and the medicament layers, between the medicament and coating layers and/or between two coating layers. The medicament in the layers may be phenylephrine or phenylephrine hydrochloride. The core may also include a medicament. The tablet is made by applying successive coatings to the core and drying the coated core at elevated temperature. The silica gel layer may be applied as powder or slurry. In an Example, a composition consisting of phenacetin, caffeine, starch and gelatin solution is formed into granules by the wet granulation method. The granules are mixed with calcium stearate, aspirin and more starch and compressed into cores. The cores are coated with (a) a composition comprising sugar, acacia and water, (b) a powder consisting of silica gel and terra alba (CaSO 4 ), (c)-(l) a suspension consisting of chloropheniramine maleate, L-phenylephrine, sugar, acacia and water alternating with the silica gel/terra alba powder, (m)-(o) three coats of a composition consisting of silical gel, terra alba, titanium dioxide, corn starch and water and (p) titanium dioxide suspended in sugar syrup. The tablet is dried after each coating of silica gel/terra alba powder.
GB44871A 1970-01-06 1971-01-05 Laminated tablets and process for their preparation Expired GB1334732A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US102370A 1970-01-06 1970-01-06

Publications (1)

Publication Number Publication Date
GB1334732A true GB1334732A (en) 1973-10-24

Family

ID=21694010

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44871A Expired GB1334732A (en) 1970-01-06 1971-01-05 Laminated tablets and process for their preparation

Country Status (12)

Country Link
BE (1) BE761276A (en)
CA (1) CA943864A (en)
CH (1) CH569475A5 (en)
DE (1) DE2100269B2 (en)
DK (1) DK127493B (en)
FR (1) FR2081411B1 (en)
GB (1) GB1334732A (en)
HU (1) HU162337B (en)
NL (1) NL7100019A (en)
SE (1) SE366916B (en)
SU (1) SU396860A3 (en)
ZA (1) ZA7155B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2230185A (en) * 1989-04-12 1990-10-17 Warner Lambert Co Differential release layered pharmaceutical tablet

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2230185A (en) * 1989-04-12 1990-10-17 Warner Lambert Co Differential release layered pharmaceutical tablet
US5085865A (en) * 1989-04-12 1992-02-04 Warner-Lambert Company Sustained release pharmaceutical preparations containing an analgesic and a decongestant
GB2230185B (en) * 1989-04-12 1993-05-12 Warner Lambert Co Sustained release pharmaceutical compositions

Also Published As

Publication number Publication date
CH569475A5 (en) 1975-11-28
DK127493B (en) 1973-11-19
DE2100269A1 (en) 1971-07-15
NL7100019A (en) 1971-07-08
FR2081411A1 (en) 1971-12-03
SU396860A3 (en) 1973-08-29
HU162337B (en) 1973-01-29
FR2081411B1 (en) 1974-04-12
DE2100269B2 (en) 1974-06-06
DE2100269C3 (en) 1975-01-23
CA943864A (en) 1974-03-19
SE366916B (en) 1974-05-13
ZA7155B (en) 1971-10-27
BE761276A (en) 1971-07-06

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees