GB1331015A - 1-substituted-6-phenyl-4h-s-triazolo-4,3-a-1,4-benzodiazepines - Google Patents
1-substituted-6-phenyl-4h-s-triazolo-4,3-a-1,4-benzodiazepinesInfo
- Publication number
- GB1331015A GB1331015A GB1487972A GB1487972A GB1331015A GB 1331015 A GB1331015 A GB 1331015A GB 1487972 A GB1487972 A GB 1487972A GB 1487972 A GB1487972 A GB 1487972A GB 1331015 A GB1331015 A GB 1331015A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- coor
- cyano
- hydroxy
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940049706 benzodiazepine Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- -1 cyano, hydroxy Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 244000052363 Cynodon dactylon Species 0.000 abstract 1
- 241000508725 Elymus repens Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 235000008515 Setaria glauca Nutrition 0.000 abstract 1
- 235000001155 Setaria leucopila Nutrition 0.000 abstract 1
- 244000010062 Setaria pumila Species 0.000 abstract 1
- 240000003461 Setaria viridis Species 0.000 abstract 1
- 235000002248 Setaria viridis Nutrition 0.000 abstract 1
- 235000010086 Setaria viridis var. viridis Nutrition 0.000 abstract 1
- 240000002439 Sorghum halepense Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical class OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13827871A | 1971-04-28 | 1971-04-28 | |
| US20120771A | 1971-11-22 | 1971-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1331015A true GB1331015A (en) | 1973-09-19 |
Family
ID=26836045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1487972A Expired GB1331015A (en) | 1971-04-28 | 1972-03-29 | 1-substituted-6-phenyl-4h-s-triazolo-4,3-a-1,4-benzodiazepines |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5541235B1 (enrdf_load_stackoverflow) |
| BE (1) | BE782680A (enrdf_load_stackoverflow) |
| CH (1) | CH571518A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2220615A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2134625B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1331015A (enrdf_load_stackoverflow) |
| NL (2) | NL7205705A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0004320A1 (en) * | 1978-03-09 | 1979-10-03 | Shionogi & Co., Ltd. | 1-Substituted-thiomethyltriazolobenzodiazepines, preparation thereof, their use, and a pharmaceutical composition |
| US4455307A (en) * | 1982-01-04 | 1984-06-19 | The Upjohn Company | Antihypertensive use of triazolobenzodiazepines |
| US4476134A (en) * | 1983-08-01 | 1984-10-09 | The Upjohn Company | Process for treating panic disorders |
| US4588721A (en) * | 1983-09-12 | 1986-05-13 | The Upjohn Company | Treatment of negative symptoms of schizophrenia |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2156472A1 (de) | 1970-11-23 | 1972-05-31 | Ciba-Geigy Ag, Basel (Schweiz) | Verfahren zur Herstellung von neuen Diazepinderivaten |
| US4902794A (en) * | 1971-04-28 | 1990-02-20 | The Upjohn Company | Triazolo-benzodiazepines |
| DE3332830A1 (de) * | 1982-09-16 | 1984-03-22 | The Upjohn Co., 49001 Kalamazoo, Mich. | Verwendung von benzodiazepinen zur bekaempfung oder bei der behandlung von panikzustaenden |
| JPS6144523A (ja) * | 1984-08-06 | 1986-03-04 | Nippon Steel Corp | 鋼片の切断装置 |
| JPS61100311A (ja) * | 1984-10-18 | 1986-05-19 | Kawasaki Steel Corp | 溶接機における切断装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
| JPS4932874B1 (enrdf_load_stackoverflow) * | 1970-12-11 | 1974-09-03 |
-
1972
- 1972-03-29 GB GB1487972A patent/GB1331015A/en not_active Expired
- 1972-04-20 JP JP3919072A patent/JPS5541235B1/ja active Pending
- 1972-04-21 CH CH596372A patent/CH571518A5/xx not_active IP Right Cessation
- 1972-04-26 BE BE782680A patent/BE782680A/xx not_active IP Right Cessation
- 1972-04-27 DE DE19722220615 patent/DE2220615A1/de not_active Withdrawn
- 1972-04-27 FR FR7215118A patent/FR2134625B1/fr not_active Expired
- 1972-04-27 NL NL7205705A patent/NL7205705A/xx unknown
-
1981
- 1981-12-23 NL NL8105804A patent/NL8105804A/nl not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0004320A1 (en) * | 1978-03-09 | 1979-10-03 | Shionogi & Co., Ltd. | 1-Substituted-thiomethyltriazolobenzodiazepines, preparation thereof, their use, and a pharmaceutical composition |
| US4455307A (en) * | 1982-01-04 | 1984-06-19 | The Upjohn Company | Antihypertensive use of triazolobenzodiazepines |
| US4476134A (en) * | 1983-08-01 | 1984-10-09 | The Upjohn Company | Process for treating panic disorders |
| US4588721A (en) * | 1983-09-12 | 1986-05-13 | The Upjohn Company | Treatment of negative symptoms of schizophrenia |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2220615A1 (de) | 1972-11-16 |
| FR2134625B1 (enrdf_load_stackoverflow) | 1975-10-17 |
| FR2134625A1 (enrdf_load_stackoverflow) | 1972-12-08 |
| NL8105804A (nl) | 1982-04-01 |
| NL7205705A (enrdf_load_stackoverflow) | 1972-10-31 |
| BE782680A (fr) | 1972-10-26 |
| JPS5541235B1 (enrdf_load_stackoverflow) | 1980-10-22 |
| CH571518A5 (enrdf_load_stackoverflow) | 1976-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SPA | Amended specification published | ||
| PE20 | Patent expired after termination of 20 years |