GB1311387A - Processes for producing 2-benzoylalkylbenzomorphan derivatives and their salts - Google Patents
Processes for producing 2-benzoylalkylbenzomorphan derivatives and their saltsInfo
- Publication number
- GB1311387A GB1311387A GB2421271A GB2421271A GB1311387A GB 1311387 A GB1311387 A GB 1311387A GB 2421271 A GB2421271 A GB 2421271A GB 2421271 A GB2421271 A GB 2421271A GB 1311387 A GB1311387 A GB 1311387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkoxy
- alkyl
- formula
- benzomorphan
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
1311387 Benzomorphan derivatives SUMITOMO CHEMICAL CO Ltd 19 April 1971 [6 April 1970(2) 10 June 1970] 24212/71 Heading C2C 2-Benzoylalkylbenzomorphan derivatives of the Formula (I) wherein R is H, OH, or C 1-3 alkoxy; R 1 is H, C 1-3 alkyl, phenyl, or phenyl substituted by C 1-3 alkyl, C 1-3 alkoxy, hydroxy, CF 3 , amino, C 1-3 alkythio, nitro, or alkanoyloxy group; R 2 is H or C 1-3 alkyl; R 3 is H, halogen, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkylthio, NO 2 , CF 3 , amino or OH group; R 4 is H, C 1-3 alkoxy, halogen, or C 1-3 alkyl; R 5 is H or CH 3 ; and n is an integer of 2 to 4, and salts thereof, all obtained by oxidizing mildly a benzomorphan derivative of Formula (II) The novel compounds of Formula (II) may be obtained by reacting a 2-acyl-benzomorphan derivative of the Formula (III) wherein m is an integer of 1 to 3 and R 6 is H, OH, C 1-3 alkoxy or a group of general formula -OCO(CH 2 ) m CO.C 6 H 3 .(R 3 )(R 4 ), with a reducing agent. The 2-acylbenzomorphan (III) may be obtained by reacting a benzomorphan (IV) with a ketocarboxylic acid (V) or a functionally active derivative thereof. The 2-benzoylalkylbenzomorphans (I) are useful as non-narcotic analgesics, being administered orally or subcutaneously.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2919070 | 1970-04-06 | ||
| JP2919170 | 1970-04-06 | ||
| JP5066770 | 1970-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1311387A true GB1311387A (en) | 1973-03-28 |
Family
ID=27286463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2421271A Expired GB1311387A (en) | 1970-04-06 | 1971-04-19 | Processes for producing 2-benzoylalkylbenzomorphan derivatives and their salts |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT309700B (en) |
| BE (1) | BE765276A (en) |
| CA (1) | CA919178A (en) |
| CH (1) | CH550799A (en) |
| DE (1) | DE2114511C3 (en) |
| DK (1) | DK134064B (en) |
| ES (1) | ES389920A1 (en) |
| FI (1) | FI53311C (en) |
| FR (1) | FR2092005B1 (en) |
| GB (1) | GB1311387A (en) |
| NL (1) | NL169878C (en) |
| NO (1) | NO136297C (en) |
| SE (1) | SE395451B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1195013A (en) * | 1957-05-09 | 1959-11-13 | Hoffmann La Roche | Process for the preparation of morphine derivatives |
| GB1276719A (en) * | 1968-12-26 | 1972-06-07 | Sumitomo Chemical Co | Benzomorphan derivatives and their salts |
-
1971
- 1971-03-25 DE DE19712114511 patent/DE2114511C3/en not_active Expired
- 1971-03-29 DK DK150371A patent/DK134064B/en not_active IP Right Cessation
- 1971-03-30 NO NO119971A patent/NO136297C/en unknown
- 1971-03-31 CH CH464671A patent/CH550799A/en not_active IP Right Cessation
- 1971-04-02 FI FI94271A patent/FI53311C/en active
- 1971-04-02 FR FR7111762A patent/FR2092005B1/fr not_active Expired
- 1971-04-05 CA CA109617A patent/CA919178A/en not_active Expired
- 1971-04-05 BE BE765276A patent/BE765276A/en unknown
- 1971-04-05 SE SE440971A patent/SE395451B/en unknown
- 1971-04-05 NL NL7104557A patent/NL169878C/en not_active IP Right Cessation
- 1971-04-05 ES ES389920A patent/ES389920A1/en not_active Expired
- 1971-04-06 AT AT293871A patent/AT309700B/en not_active IP Right Cessation
- 1971-04-19 GB GB2421271A patent/GB1311387A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2114511C3 (en) | 1979-05-10 |
| FR2092005B1 (en) | 1975-03-14 |
| DK134064C (en) | 1977-04-04 |
| SE395451B (en) | 1977-08-15 |
| ES389920A1 (en) | 1973-06-01 |
| CA919178A (en) | 1973-01-16 |
| CH550799A (en) | 1974-06-28 |
| DK134064B (en) | 1976-09-06 |
| NO136297C (en) | 1977-08-17 |
| FI53311B (en) | 1977-12-30 |
| NO136297B (en) | 1977-05-09 |
| DE2114511A1 (en) | 1971-10-21 |
| FI53311C (en) | 1978-04-10 |
| NL169878C (en) | 1982-09-01 |
| NL169878B (en) | 1982-04-01 |
| AT309700B (en) | 1973-08-27 |
| NL7104557A (en) | 1971-10-08 |
| FR2092005A1 (en) | 1972-01-21 |
| BE765276A (en) | 1971-08-30 |
| DE2114511B2 (en) | 1978-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |