GB1311286A - Compositions for the relief of migraine - Google Patents

Compositions for the relief of migraine

Info

Publication number
GB1311286A
GB1311286A GB5964369A GB5964369A GB1311286A GB 1311286 A GB1311286 A GB 1311286A GB 5964369 A GB5964369 A GB 5964369A GB 5964369 A GB5964369 A GB 5964369A GB 1311286 A GB1311286 A GB 1311286A
Authority
GB
United Kingdom
Prior art keywords
migraine
compositions
paracetamol
dec
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5964369A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB5964369A priority Critical patent/GB1311286A/en
Priority to ZA708099*A priority patent/ZA708099B/en
Priority to NL7017680A priority patent/NL7017680A/xx
Priority to SE7016368A priority patent/SE384135B/en
Priority to IE1554/70A priority patent/IE35154B1/en
Priority to BE759897D priority patent/BE759897A/en
Priority to FR7043778A priority patent/FR2081330B1/fr
Priority to DE19702059747 priority patent/DE2059747C3/en
Priority to AT1096570A priority patent/AT312161B/en
Priority to CA099,931A priority patent/CA967882A/en
Publication of GB1311286A publication Critical patent/GB1311286A/en
Priority to CY71774A priority patent/CY717A/en
Priority to US05/638,006 priority patent/US4017614A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1311286 Migraine treatment H WILD 4 Dec 1970 [5 Dec 1969] 59643/69 Heading A5B Pharmaceutical compositions for the treatment and prevention of migraine comprise (a) a 1, 4-disubstituted piperazine having the general formula: wherein X is H, Cl or Br and R<SP>1</SP> and R<SP>2</SP> each represent H or a C 1-6 alkyl, at least one of R<SP>1</SP> and R<SP>2</SP> being an alkyl group, or a salt thereof e.g. salts with hydrochloric, phosphoric, lactic, maleic, fumaric and tartaric acids, and (b) N-acetyl-p-aminophenol (paracetamol), pethoxyacetanilide (phenacetin), salicylamide and/or acetylsalicylic acid, the weight ratio of (a) to (b) being from 1:20 to 1:200. A preferred composition comprises 1-p-chlorobenzhydryl-4- p-(tertiary butyl) benzyl piperazine (buclizine) and paracetamol. The compositions may be administered orally or rectally in the form of tablets, capsules, suspensions, syrups, and suppositories. Migraine may be prevented by the simultaneous administration of dosage units comprising appropriate quantities of (a) and (b) and the invention also relates to a pharmaceutical package comprising separate dosage unit forms containing (a) and (b). The composition may also be formulated as a dosage form divided into separate portions by an internal division which is easily ruptured or dissolved by body fluid, compounds (a) and (b) being confined to different compartments. The compositions may also contain additional analgesics such as codeine or dextropropoxyphene.
GB5964369A 1969-12-05 1969-12-05 Compositions for the relief of migraine Expired GB1311286A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB5964369A GB1311286A (en) 1969-12-05 1969-12-05 Compositions for the relief of migraine
ZA708099*A ZA708099B (en) 1969-12-05 1970-11-30 Compositions for the relief of migraine
NL7017680A NL7017680A (en) 1969-12-05 1970-12-03
SE7016368A SE384135B (en) 1969-12-05 1970-12-03 PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF MIGRAINE, CONTAINING 1- (P-TERT-BUTYL BENZYL) -4- (P-CHLORO-ALFA-PHENYL BENZYL) -PIPERAZINE
BE759897D BE759897A (en) 1969-12-05 1970-12-04 PHARMACEUTICAL COMPOSITIONS INTENDED TO RELIEVE MIGRAINE
IE1554/70A IE35154B1 (en) 1969-12-05 1970-12-04 Compositions for the relief of migraine
FR7043778A FR2081330B1 (en) 1969-12-05 1970-12-04
DE19702059747 DE2059747C3 (en) 1969-12-05 1970-12-04 Orally or rectally administrable pharmaceutical preparation for the treatment of migraines
AT1096570A AT312161B (en) 1969-12-05 1970-12-07 Process for the production of a pharmaceutical preparation
CA099,931A CA967882A (en) 1969-12-05 1970-12-07 Compositions for the relief of migraine
CY71774A CY717A (en) 1969-12-05 1974-01-28 Compositions for the relief of migraine
US05/638,006 US4017614A (en) 1969-12-05 1975-12-05 Compositions for the relief of migraine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5964369A GB1311286A (en) 1969-12-05 1969-12-05 Compositions for the relief of migraine

Publications (1)

Publication Number Publication Date
GB1311286A true GB1311286A (en) 1973-03-28

Family

ID=10484150

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5964369A Expired GB1311286A (en) 1969-12-05 1969-12-05 Compositions for the relief of migraine

Country Status (10)

Country Link
AT (1) AT312161B (en)
BE (1) BE759897A (en)
CA (1) CA967882A (en)
CY (1) CY717A (en)
FR (1) FR2081330B1 (en)
GB (1) GB1311286A (en)
IE (1) IE35154B1 (en)
NL (1) NL7017680A (en)
SE (1) SE384135B (en)
ZA (1) ZA708099B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0031561A2 (en) * 1979-12-20 1981-07-08 Merck & Co. Inc. A rectally administered suppository comprising a drug and an adjuvant

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8521350D0 (en) * 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0031561A2 (en) * 1979-12-20 1981-07-08 Merck & Co. Inc. A rectally administered suppository comprising a drug and an adjuvant
EP0031561A3 (en) * 1979-12-20 1982-08-11 Merck & Co. Inc. A rectally administered drug form comprising a drug and an adjuvant
DK156121B (en) * 1979-12-20 1989-06-26 Merck & Co Inc PROCEDURE FOR PREPARING A RECTAL ADMINISTRATIVE SUPPLY WITH A ADJUVANCE

Also Published As

Publication number Publication date
CY717A (en) 1974-01-28
NL7017680A (en) 1971-06-08
FR2081330A1 (en) 1971-12-03
ZA708099B (en) 1971-08-25
AT312161B (en) 1973-12-27
IE35154L (en) 1971-06-05
SE384135B (en) 1976-04-26
IE35154B1 (en) 1975-11-26
CA967882A (en) 1975-05-20
FR2081330B1 (en) 1974-10-11
DE2059747A1 (en) 1971-06-09
DE2059747B2 (en) 1976-04-22
BE759897A (en) 1971-05-17

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years