GB1310612A - 17alpha-3-substituted propynyl steroids - Google Patents
17alpha-3-substituted propynyl steroidsInfo
- Publication number
- GB1310612A GB1310612A GB4115872A GB4115870A GB1310612A GB 1310612 A GB1310612 A GB 1310612A GB 4115872 A GB4115872 A GB 4115872A GB 4115870 A GB4115870 A GB 4115870A GB 1310612 A GB1310612 A GB 1310612A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acyl
- steroids
- alkyl
- products
- tetrahydropyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 propynyl steroids Chemical class 0.000 title abstract 5
- 125000002252 acyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 2
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 230000032050 esterification Effects 0.000 abstract 2
- 238000005886 esterification reaction Methods 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- HRDCVMSNCBAMAM-UHFFFAOYSA-N 3-prop-2-ynoxyprop-1-yne Chemical class C#CCOCC#C HRDCVMSNCBAMAM-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000002164 estratrienes Chemical class 0.000 abstract 1
- 238000006266 etherification reaction Methods 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 abstract 1
- FRIJBUGBVQZNTB-UHFFFAOYSA-M magnesium;ethane;bromide Chemical compound [Mg+2].[Br-].[CH2-]C FRIJBUGBVQZNTB-UHFFFAOYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920002866 paraformaldehyde Polymers 0.000 abstract 1
- 230000009467 reduction Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81756369A | 1969-04-18 | 1969-04-18 | |
| US87752169A | 1969-11-17 | 1969-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1310612A true GB1310612A (en) | 1973-03-21 |
Family
ID=27124181
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1767570A Expired GB1310611A (en) | 1969-04-18 | 1970-04-14 | Propadienyl steroids and method for their production |
| GB4115872A Expired GB1310612A (en) | 1969-04-18 | 1970-04-14 | 17alpha-3-substituted propynyl steroids |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1767570A Expired GB1310611A (en) | 1969-04-18 | 1970-04-14 | Propadienyl steroids and method for their production |
Country Status (15)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH571537A5 (enrdf_load_stackoverflow) * | 1970-04-24 | 1976-01-15 | Sandoz Ag | |
| GB1348186A (en) * | 1970-04-24 | 1974-03-13 | Sandoz Ltd | 17alpha-propadienyl steroids |
-
1970
- 1970-04-02 IL IL34228A patent/IL34228A/xx unknown
- 1970-04-06 CA CA079239A patent/CA919167A/en not_active Expired
- 1970-04-13 FI FI701016A patent/FI47985C/fi active
- 1970-04-14 GB GB1767570A patent/GB1310611A/en not_active Expired
- 1970-04-14 GB GB4115872A patent/GB1310612A/en not_active Expired
- 1970-04-15 DE DE19702018055 patent/DE2018055B2/de active Pending
- 1970-04-15 CH CH560270A patent/CH540894A/de not_active IP Right Cessation
- 1970-04-15 AT AT342970A patent/AT322120B/de not_active IP Right Cessation
- 1970-04-16 BE BE749067D patent/BE749067A/xx unknown
- 1970-04-17 JP JP45032883A patent/JPS4916857B1/ja active Pending
- 1970-04-17 ES ES378764A patent/ES378764A1/es not_active Expired
- 1970-04-17 NL NL7005604A patent/NL7005604A/xx unknown
- 1970-04-17 NO NO1467/70A patent/NO134553C/no unknown
- 1970-04-17 DK DK195170A patent/DK133813C/da active
- 1970-04-17 FR FR707014098A patent/FR2051496B1/fr not_active Expired
- 1970-04-17 SE SE05322/70A patent/SE355802B/xx unknown
-
1974
- 1974-01-29 IL IL44105A patent/IL44105A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI47985C (fi) | 1974-05-10 |
| FR2051496B1 (enrdf_load_stackoverflow) | 1973-03-16 |
| DE2018055B2 (de) | 1976-12-23 |
| GB1310611A (en) | 1973-03-21 |
| IL34228A0 (en) | 1970-06-17 |
| JPS4916857B1 (enrdf_load_stackoverflow) | 1974-04-25 |
| DE2018055A1 (de) | 1970-10-22 |
| DK133813B (da) | 1976-07-26 |
| NO134553C (enrdf_load_stackoverflow) | 1976-11-03 |
| CA919167A (en) | 1973-01-16 |
| IL34228A (en) | 1975-04-25 |
| FI47985B (enrdf_load_stackoverflow) | 1974-01-31 |
| DK133813C (da) | 1976-12-13 |
| ES378764A1 (es) | 1973-02-01 |
| AT322120B (de) | 1975-05-12 |
| NL7005604A (enrdf_load_stackoverflow) | 1970-10-20 |
| CH540894A (de) | 1973-08-31 |
| IL44105A0 (en) | 1974-05-16 |
| SE355802B (enrdf_load_stackoverflow) | 1973-05-07 |
| NO134553B (enrdf_load_stackoverflow) | 1976-07-26 |
| FR2051496A1 (enrdf_load_stackoverflow) | 1971-04-09 |
| BE749067A (fr) | 1970-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |