GB1348186A - 17alpha-propadienyl steroids - Google Patents
17alpha-propadienyl steroidsInfo
- Publication number
- GB1348186A GB1348186A GB993171*[A GB993171A GB1348186A GB 1348186 A GB1348186 A GB 1348186A GB 993171 A GB993171 A GB 993171A GB 1348186 A GB1348186 A GB 1348186A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- steroids
- compounds
- ketals
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
Abstract
1348186 17α-Propadienyl-steroids SANDOZ Ltd 19 April 1971 [24 April 1970] 9931/71 Heading C2U [Also in Division A5] Novel steroids of the formula (wherein R is CH 3 , C 2 H 5 or n-C 3 H 7 ) are prepared (1) by dehydrogenation of the corresponding #<SP>5(10),9(11)</SP>-steroids using a suitable quinone; or (2) by acid hydrolysis of the corresponding 3-ketals. Starting materials of the formula are prepared by acid hydrolysis of the corresponding 3-ketals. These ketals and the starting materials of the formula (where K is a ketal function) are prepared by reacting the corresponding 17-ones with compounds P-C#C-CH 2 NR 1 R 2 (wherein P is an active metal or metal halide radical and R 1 and R 2 are each C 1-3 alkyl or NR 1 R 2 is pyrrolidino, piperidino or homopiperidino) to form the corresponding 17α - (C#C-CH 2 -NR 1 R 2 )- 17#-ols (which may also be prepared from the corresponding 17α-ethynyl compounds and compounds HO-CH 2 -NR 1 R 2 , the ethynyl compounds being in turn prepared from the 17-ones), quaternizing these with a reagent R 3 X (wherein R 3 is C 1-3 alkyl and X is the residue of a mineral acid other than HF or of an alkyl- or aromaticsulphonic acid) and reducing the quaternary derivatives with a hydride ion source. Reference has been directed by the Comptroller to Specification 1,310,611.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3178270A | 1970-04-24 | 1970-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1348186A true GB1348186A (en) | 1974-03-13 |
Family
ID=21861362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB993171*[A Expired GB1348186A (en) | 1970-04-24 | 1971-04-19 | 17alpha-propadienyl steroids |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | ATA353071A (en) |
| AU (1) | AU2810571A (en) |
| BE (1) | BE766148A (en) |
| CA (1) | CA945141A (en) |
| CS (1) | CS155974B2 (en) |
| DE (1) | DE2119328A1 (en) |
| ES (1) | ES390456A1 (en) |
| FR (1) | FR2092083B1 (en) |
| GB (1) | GB1348186A (en) |
| NL (1) | NL7105446A (en) |
| ZA (2) | ZA712601B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127071C (en) * | 1964-12-31 | |||
| IL34228A (en) * | 1969-04-18 | 1975-04-25 | Syntex Corp | The preparation of 17alpha-propadienyl steroids and novel 17alpha-(3-substituted propynyl)steroidal intermediates |
-
1971
- 1971-04-19 GB GB993171*[A patent/GB1348186A/en not_active Expired
- 1971-04-21 DE DE19712119328 patent/DE2119328A1/en active Pending
- 1971-04-22 CA CA111,058A patent/CA945141A/en not_active Expired
- 1971-04-22 NL NL7105446A patent/NL7105446A/xx unknown
- 1971-04-22 BE BE766148A patent/BE766148A/en unknown
- 1971-04-22 ZA ZA712601A patent/ZA712601B/en unknown
- 1971-04-22 FR FR7114358A patent/FR2092083B1/fr not_active Expired
- 1971-04-22 ES ES390456A patent/ES390456A1/en not_active Expired
- 1971-04-23 AT AT713530A patent/ATA353071A/en not_active IP Right Cessation
- 1971-04-23 AU AU28105/71A patent/AU2810571A/en not_active Expired
- 1971-04-23 ZA ZA712643A patent/ZA712643B/en unknown
- 1971-04-23 CS CS299571A patent/CS155974B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2092083A1 (en) | 1972-01-21 |
| CA945141A (en) | 1974-04-09 |
| BE766148A (en) | 1971-10-22 |
| ZA712643B (en) | 1972-11-29 |
| ES390456A1 (en) | 1974-07-01 |
| FR2092083B1 (en) | 1974-08-23 |
| AU2810571A (en) | 1972-10-26 |
| DE2119328A1 (en) | 1971-11-11 |
| CS155974B2 (en) | 1974-06-24 |
| NL7105446A (en) | 1971-10-26 |
| ZA712601B (en) | 1972-11-29 |
| ATA353071A (en) | 1975-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |