GB1310236A - Morpholine derivatives - Google Patents
Morpholine derivativesInfo
- Publication number
- GB1310236A GB1310236A GB1310236DA GB1310236A GB 1310236 A GB1310236 A GB 1310236A GB 1310236D A GB1310236D A GB 1310236DA GB 1310236 A GB1310236 A GB 1310236A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- prepared
- benzyloxy
- compounds
- allyloxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002780 morpholines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 sulphonyloxy Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- VGPHTTKTZQGSHW-UHFFFAOYSA-N (4-benzyl-6-methylmorpholin-2-yl)methanol Chemical compound C1C(CO)OC(C)CN1CC1=CC=CC=C1 VGPHTTKTZQGSHW-UHFFFAOYSA-N 0.000 abstract 1
- WQNIKIMRIXHNFF-UHFFFAOYSA-N (4-benzylmorpholin-2-yl)methanol Chemical compound C1COC(CO)CN1CC1=CC=CC=C1 WQNIKIMRIXHNFF-UHFFFAOYSA-N 0.000 abstract 1
- STMDPCBYJCIZOD-UHFFFAOYSA-N 2-(2,4-dinitroanilino)-4-methylpentanoic acid Chemical compound CC(C)CC(C(O)=O)NC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O STMDPCBYJCIZOD-UHFFFAOYSA-N 0.000 abstract 1
- HFAPDVYSAZNCTD-UHFFFAOYSA-N 2-(2-hydroxy-4-phenylmethoxyphenyl)benzoic acid Chemical compound C1=CC=C(C=C1)COC2=CC(=C(C=C2)C3=CC=CC=C3C(=O)O)O HFAPDVYSAZNCTD-UHFFFAOYSA-N 0.000 abstract 1
- FQZKWFGQYRVSEU-UHFFFAOYSA-N 2-[2-(oxan-2-yloxy)-4-phenylmethoxyphenyl]benzoic acid Chemical compound C1CCOC(C1)OC2=C(C=CC(=C2)OCC3=CC=CC=C3)C4=CC=CC=C4C(=O)O FQZKWFGQYRVSEU-UHFFFAOYSA-N 0.000 abstract 1
- FIQVOJIGLUGERG-UHFFFAOYSA-N 2-ethoxy-5-phenylmethoxyphenol Chemical compound C(C1=CC=CC=C1)OC=1C=CC(=C(C1)O)OCC FIQVOJIGLUGERG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004342 Benzoyl peroxide Substances 0.000 abstract 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 235000019400 benzoyl peroxide Nutrition 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Breakers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2466870 | 1970-05-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1310236A true GB1310236A (en) | 1973-03-14 |
Family
ID=10215379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1310236D Expired GB1310236A (en) | 1970-05-21 | 1970-05-21 | Morpholine derivatives |
Country Status (11)
| Country | Link |
|---|---|
| CH (1) | CH564000A5 (enrdf_load_stackoverflow) |
| CS (1) | CS163254B2 (enrdf_load_stackoverflow) |
| DD (1) | DD97207A5 (enrdf_load_stackoverflow) |
| DK (1) | DK149105C (enrdf_load_stackoverflow) |
| GB (1) | GB1310236A (enrdf_load_stackoverflow) |
| HU (1) | HU163286B (enrdf_load_stackoverflow) |
| NO (1) | NO136409C (enrdf_load_stackoverflow) |
| PL (1) | PL83865B1 (enrdf_load_stackoverflow) |
| SE (1) | SE387118B (enrdf_load_stackoverflow) |
| SU (1) | SU472506A3 (enrdf_load_stackoverflow) |
| YU (1) | YU35247B (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4547584A (en) * | 1983-12-29 | 1985-10-15 | General Foods Corporation | 3-Hydroxy-4-methoxyphenyl benzoates |
| WO1998007710A1 (en) * | 1996-08-23 | 1998-02-26 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists |
| US20220306618A1 (en) * | 2021-03-18 | 2022-09-29 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
| EP4317141A1 (en) * | 2022-08-04 | 2024-02-07 | Curia Spain S.A.U. | Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives |
-
1970
- 1970-05-21 GB GB1310236D patent/GB1310236A/en not_active Expired
-
1971
- 1971-05-18 SE SE644971A patent/SE387118B/xx unknown
- 1971-05-19 DK DK242571A patent/DK149105C/da not_active IP Right Cessation
- 1971-05-19 PL PL14825671A patent/PL83865B1/pl unknown
- 1971-05-19 NO NO188871A patent/NO136409C/no unknown
- 1971-05-20 YU YU128671A patent/YU35247B/xx unknown
- 1971-05-21 CS CS376771A patent/CS163254B2/cs unknown
- 1971-05-21 SU SU1660729A patent/SU472506A3/ru active
- 1971-05-21 HU HUIE000450 patent/HU163286B/hu unknown
- 1971-05-21 CH CH748571A patent/CH564000A5/xx not_active IP Right Cessation
- 1971-05-21 DD DD15527671A patent/DD97207A5/xx unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4547584A (en) * | 1983-12-29 | 1985-10-15 | General Foods Corporation | 3-Hydroxy-4-methoxyphenyl benzoates |
| WO1998007710A1 (en) * | 1996-08-23 | 1998-02-26 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists |
| US6207662B1 (en) | 1996-08-23 | 2001-03-27 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine D4 receptor antagonists |
| US6479491B1 (en) | 1996-08-23 | 2002-11-12 | Neurosearch A/S | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists |
| US20220306618A1 (en) * | 2021-03-18 | 2022-09-29 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
| US11919889B2 (en) * | 2021-03-18 | 2024-03-05 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
| US12215097B2 (en) | 2021-03-18 | 2025-02-04 | Supernus Pharmaceuticals, Inc. | Derivatives of substituted morpholines and uses thereof |
| EP4317141A1 (en) * | 2022-08-04 | 2024-02-07 | Curia Spain S.A.U. | Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives |
| WO2024028423A1 (en) * | 2022-08-04 | 2024-02-08 | Curia Spain, S.A.U. | Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| CH564000A5 (enrdf_load_stackoverflow) | 1975-07-15 |
| SE387118B (sv) | 1976-08-30 |
| PL83865B1 (enrdf_load_stackoverflow) | 1976-02-28 |
| DD97207A5 (enrdf_load_stackoverflow) | 1973-04-20 |
| DK149105B (da) | 1986-01-27 |
| NO136409B (enrdf_load_stackoverflow) | 1977-05-23 |
| NO136409C (no) | 1977-08-31 |
| DK149105C (da) | 1986-07-21 |
| HU163286B (enrdf_load_stackoverflow) | 1973-07-28 |
| SU472506A3 (ru) | 1975-05-30 |
| YU35247B (en) | 1980-10-31 |
| YU128671A (en) | 1980-04-30 |
| CS163254B2 (enrdf_load_stackoverflow) | 1975-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |