GB1304174A - - Google Patents
Info
- Publication number
- GB1304174A GB1304174A GB1215869A GB1304174DA GB1304174A GB 1304174 A GB1304174 A GB 1304174A GB 1215869 A GB1215869 A GB 1215869A GB 1304174D A GB1304174D A GB 1304174DA GB 1304174 A GB1304174 A GB 1304174A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- phenyl
- biphenylyl
- dimethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/10—The polymethine chain containing an even number of >CH- groups
- C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L23/00—Details of semiconductor or other solid state devices
- H01L23/48—Arrangements for conducting electric current to or from the solid state body in operation, e.g. leads, terminal arrangements ; Selection of materials therefor
- H01L23/488—Arrangements for conducting electric current to or from the solid state body in operation, e.g. leads, terminal arrangements ; Selection of materials therefor consisting of soldered or bonded constructions
- H01L23/498—Leads, i.e. metallisations or lead-frames on insulating substrates, e.g. chip carriers
- H01L23/49827—Via connections through the substrates, e.g. pins going through the substrate, coaxial cables
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/0001—Technical content checked by a classifier
- H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
Abstract
1304174 Pyrrylvinylthiazolium salts WELL- - COME FOUNDATION Ltd (Burroughs Wellcome & Co USA Inc) 5 March 1970 [7 March 1969] 12158/69 Headings C2C and C2P Compounds (I): (where R is 1-6C alkyl or optionally substituted phenyl; Z is Ph, p-halophenyl, p-alkoxyphenyl, biphenylyl, p-alkoxy biphenylyl or naphthyl and X- is the anion of a pharmaceutically acceptable acid) are prepared (1) by reacting a compound (II) with a compound: (III): and optionally forming the salt or (2) by ring closure of a compound (IV): in which the compound IV may be prepared in situ by reacting a compound (V): with a compound Z-CO-CH 2 A. The following starting materials are prepared: 2 - methyl - 4 - p - biphenylyl thiazole and its methiodide; 2,5 - dimethyl - 1 - phenylpyrrole and 1 - phenyl - 2,5 - dimethylpyrrole - 3 - carboxaldehyde; 3 - (2,5 - dimethyl - 1 - phenylpyrrol-3-yl) acrylomethylamide and its thioamide and p - phenyl - phenacyl - N - methyl - 3- (2,5 - dimethyl - 1 - phenyl - pyrrol - 3 - yl)- acrylothioimidate - HBr; 3 - (1,2,5 - trimethylpyrrol - 3 - yl) acrylomethylamide and its thioamide and p - bromophenacyl - N - methyl - 3- (1,2,5 - trimethylpyrrol - 3 - yl) acrylothioimidate HBr, and N-methylcarbamoylmethyltriphenylphosphonium chloride. Pharmaceutical compositions useful in treating nematode infection are in forms suitable for oral administration.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1215869 | 1969-03-07 | ||
US1594470A | 1970-03-02 | 1970-03-02 | |
US00215926A US3851060A (en) | 1969-03-07 | 1972-01-06 | Composition and methods for treating nematode infections |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1304174A true GB1304174A (en) | 1973-01-24 |
Family
ID=27256795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1215869A Expired GB1304174A (en) | 1969-03-07 | 1969-03-07 |
Country Status (9)
Country | Link |
---|---|
US (1) | US3851060A (en) |
BE (1) | BE746998A (en) |
CA (1) | CA960667A (en) |
CH (2) | CH574958A5 (en) |
DE (1) | DE2010490A1 (en) |
FR (1) | FR2096715B1 (en) |
GB (1) | GB1304174A (en) |
NL (1) | NL7003246A (en) |
SE (1) | SE368709B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298743A (en) * | 1979-09-11 | 1981-11-03 | Merck & Co., Inc. | 4-(Substituted phenyl thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones |
RU2007127310A (en) * | 2004-12-17 | 2009-01-27 | Майкосол, Инк. (Us) | COMPOUNDS OF THIAZOLIA AND THEIR APPLICATION |
WO2007056340A2 (en) * | 2005-11-08 | 2007-05-18 | Mycosol, Inc. | Disinfectant and antiseptic pyridinium and thiazolium compounds and methods of using the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3390148A (en) * | 1965-07-28 | 1968-06-25 | Pfizer & Co C | Novel thiazine and thiazoline anthelmintic agents |
GB1244961A (en) * | 1967-09-22 | 1971-09-02 | Burroughs Wellcome Co | Thiazole derivatives |
-
1969
- 1969-03-07 GB GB1215869A patent/GB1304174A/en not_active Expired
-
1970
- 1970-03-05 DE DE19702010490 patent/DE2010490A1/en active Pending
- 1970-03-06 CA CA076,734A patent/CA960667A/en not_active Expired
- 1970-03-06 CH CH1263372A patent/CH574958A5/xx not_active IP Right Cessation
- 1970-03-06 CH CH336870A patent/CH555857A/en not_active IP Right Cessation
- 1970-03-06 NL NL7003246A patent/NL7003246A/xx unknown
- 1970-03-06 BE BE746998D patent/BE746998A/en unknown
- 1970-03-06 SE SE03000/70A patent/SE368709B/xx unknown
- 1970-03-09 FR FR7008340A patent/FR2096715B1/fr not_active Expired
-
1972
- 1972-01-06 US US00215926A patent/US3851060A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CH555857A (en) | 1974-11-15 |
CA960667A (en) | 1975-01-07 |
FR2096715B1 (en) | 1974-02-01 |
US3851060A (en) | 1974-11-26 |
FR2096715A1 (en) | 1972-02-25 |
BE746998A (en) | 1970-09-07 |
NL7003246A (en) | 1970-09-09 |
SE368709B (en) | 1974-07-15 |
DE2010490A1 (en) | 1970-09-24 |
CH574958A5 (en) | 1976-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
416 | Proceeding under section 16 patents act 1949 | ||
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |