GB1303724A - - Google Patents
Info
- Publication number
- GB1303724A GB1303724A GB2018270A GB2018270A GB1303724A GB 1303724 A GB1303724 A GB 1303724A GB 2018270 A GB2018270 A GB 2018270A GB 2018270 A GB2018270 A GB 2018270A GB 1303724 A GB1303724 A GB 1303724A
- Authority
- GB
- United Kingdom
- Prior art keywords
- wortmannin
- desacetoxy
- antibiotic
- formula
- fungistatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GXVZXRZMWGYXMQ-UHFFFAOYSA-N 11-Desacetoxywortmannin Natural products C12CCC(=O)C1(C)CCC1=C2C(=O)C2=C3C(=CO2)C(=O)OC(COC)C13C GXVZXRZMWGYXMQ-UHFFFAOYSA-N 0.000 abstract 5
- GXVZXRZMWGYXMQ-DJOOALQISA-N 11-desacetoxywortmannin Chemical compound C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)CC1 GXVZXRZMWGYXMQ-DJOOALQISA-N 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 230000003115 biocidal effect Effects 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 230000001408 fungistatic effect Effects 0.000 abstract 2
- QDLHCMPXEPAAMD-QAIWCSMKSA-N wortmannin Chemical compound C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 abstract 2
- QDLHCMPXEPAAMD-UHFFFAOYSA-N wortmannin Natural products COCC1OC(=O)C2=COC(C3=O)=C2C1(C)C1=C3C2CCC(=O)C2(C)CC1OC(C)=O QDLHCMPXEPAAMD-UHFFFAOYSA-N 0.000 abstract 2
- 241000750600 Aspergillus janus Species 0.000 abstract 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 241001136494 Talaromyces funiculosus Species 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 239000000391 magnesium silicate Substances 0.000 abstract 1
- 229910052919 magnesium silicate Inorganic materials 0.000 abstract 1
- 235000019792 magnesium silicate Nutrition 0.000 abstract 1
- ZADYMNAVLSWLEQ-UHFFFAOYSA-N magnesium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[Mg+2].[Si+4] ZADYMNAVLSWLEQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000012299 nitrogen atmosphere Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH734969A CH520163A (de) | 1969-05-14 | 1969-05-14 | Verfahren zur Herstellung von 11-Desacetoxy-wortmannin |
| CH1348569A CH523317A (de) | 1969-09-10 | 1969-09-10 | Verfahren zur Herstellung eines neuen Antibioticums |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1303724A true GB1303724A (enrdf_load_stackoverflow) | 1973-01-17 |
Family
ID=25701168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2018270A Expired GB1303724A (enrdf_load_stackoverflow) | 1969-05-14 | 1970-04-27 |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU1501370A (enrdf_load_stackoverflow) |
| BE (1) | BE750303A (enrdf_load_stackoverflow) |
| DE (1) | DE2022452A1 (enrdf_load_stackoverflow) |
| DK (1) | DK128006B (enrdf_load_stackoverflow) |
| FR (1) | FR2051522B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1303724A (enrdf_load_stackoverflow) |
| IL (1) | IL34514A (enrdf_load_stackoverflow) |
| NL (1) | NL7006514A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
| US7105518B2 (en) | 2001-08-14 | 2006-09-12 | Cancer Research Technology Limited | Thiopyrane-4-ones as DNA protein kinase inhibitors |
| US7226918B2 (en) | 2001-08-14 | 2007-06-05 | Cancer Research Technology Limited | DNA-PK inhibitors |
| US7402607B2 (en) | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
| US7429660B2 (en) | 2003-08-13 | 2008-09-30 | Kudos Pharmaceuticals Limited | ATM inhibitors |
| US7642254B2 (en) | 2005-02-09 | 2010-01-05 | Kudos Pharmaceuticals Limited | ATM inhibitors |
| US7696203B2 (en) | 2005-04-15 | 2010-04-13 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
-
1970
- 1970-04-27 GB GB2018270A patent/GB1303724A/en not_active Expired
- 1970-05-04 NL NL7006514A patent/NL7006514A/xx unknown
- 1970-05-08 DE DE19702022452 patent/DE2022452A1/de active Pending
- 1970-05-12 BE BE750303D patent/BE750303A/xx unknown
- 1970-05-12 DK DK239770AA patent/DK128006B/da unknown
- 1970-05-12 FR FR707017286A patent/FR2051522B1/fr not_active Expired
- 1970-05-13 IL IL34514A patent/IL34514A/xx unknown
- 1970-05-13 AU AU15013/70A patent/AU1501370A/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105518B2 (en) | 2001-08-14 | 2006-09-12 | Cancer Research Technology Limited | Thiopyrane-4-ones as DNA protein kinase inhibitors |
| US7226918B2 (en) | 2001-08-14 | 2007-06-05 | Cancer Research Technology Limited | DNA-PK inhibitors |
| US7674823B2 (en) | 2001-08-14 | 2010-03-09 | Cancer Research Technology Limited | DNA-PK inhibitors |
| US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
| US7429660B2 (en) | 2003-08-13 | 2008-09-30 | Kudos Pharmaceuticals Limited | ATM inhibitors |
| US7402607B2 (en) | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
| US7732483B2 (en) | 2004-09-20 | 2010-06-08 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
| US7642254B2 (en) | 2005-02-09 | 2010-01-05 | Kudos Pharmaceuticals Limited | ATM inhibitors |
| US7696203B2 (en) | 2005-04-15 | 2010-04-13 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2022452A1 (de) | 1970-12-17 |
| BE750303A (fr) | 1970-11-12 |
| FR2051522B1 (enrdf_load_stackoverflow) | 1973-08-10 |
| FR2051522A1 (enrdf_load_stackoverflow) | 1971-04-09 |
| DK128006B (da) | 1974-02-18 |
| NL7006514A (enrdf_load_stackoverflow) | 1970-11-17 |
| AU1501370A (en) | 1971-11-18 |
| IL34514A (en) | 1974-01-14 |
| IL34514A0 (en) | 1970-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |