GB1301454A - - Google Patents

Info

Publication number
GB1301454A
GB1301454A GB1301454DA GB1301454A GB 1301454 A GB1301454 A GB 1301454A GB 1301454D A GB1301454D A GB 1301454DA GB 1301454 A GB1301454 A GB 1301454A
Authority
GB
United Kingdom
Prior art keywords
naphthyl
methoxy
maintaining
acid
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1301454A publication Critical patent/GB1301454A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1301454 Preparation of methoxynaphthylpropionic acid SYNTEX CORP 20 Jan 1970 [30 Sept 1969] 31644/72 Divided out of 1300591 Addition to 1274271 Heading C2C 2 - (6 - Methoxy - 2 - naphthyl) propionic acid is prepared by (1) maintaining a non-aqueous solution of 2-(6-methoxy-2-naphthyl) propionitrile, a strong acid and an aliphatic alcohol with up to 10C at at least 60‹ C. until an orthoester is formed, mixing water with the reaction mixture and maintaining it at an elevated temperature or (2) maintaining a non-aqueous solution of 2-(6-methoxy-2-naphthyl) propion. aldoxime, a strong acid and an aliphatic alcohol with up to 10C at at least 60‹ C. for at least 1 hour, mixing water with the mixture and maintaining it at an elevated temperature. A dlmixture, thus formed, may be resolved, if desired. Pharmaceutical compositions comprising 2-(6- methoxy-2-naphthyl) propionic acid, when prepared as above, with an excipient are used in treating inflammation, pain and pyrexia.
GB1301454D 1969-09-30 1970-01-20 Expired GB1301454A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86246769A 1969-09-30 1969-09-30
US86246869A 1969-09-30 1969-09-30
US85348169A 1969-09-30 1969-09-30

Publications (1)

Publication Number Publication Date
GB1301454A true GB1301454A (en) 1972-12-29

Family

ID=27420367

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1301454D Expired GB1301454A (en) 1969-09-30 1970-01-20

Country Status (1)

Country Link
GB (1) GB1301454A (en)

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees