GB1301442A - - Google Patents
Info
- Publication number
- GB1301442A GB1301442A GB1301442DA GB1301442A GB 1301442 A GB1301442 A GB 1301442A GB 1301442D A GB1301442D A GB 1301442DA GB 1301442 A GB1301442 A GB 1301442A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- acid
- naphthyl
- treating
- corresponding amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- GGWCZBGAIGGTDA-UHFFFAOYSA-N 1-(6-methoxynaphthalen-2-yl)ethanone Chemical compound C1=C(C(C)=O)C=CC2=CC(OC)=CC=C21 GGWCZBGAIGGTDA-UHFFFAOYSA-N 0.000 abstract 2
- CMWTZPSULFXXJA-UHFFFAOYSA-N 2-(6-methoxy-2-naphthalenyl)propanoic acid Chemical compound C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- UPEGIZOAIZVQDQ-UHFFFAOYSA-N 2-(6-methoxynaphthalen-2-yl)-2-methyloxirane Chemical compound C1=CC2=CC(OC)=CC=C2C=C1C1(C)CO1 UPEGIZOAIZVQDQ-UHFFFAOYSA-N 0.000 abstract 1
- YVWMPILNFZOQSZ-UHFFFAOYSA-N 2-methoxy-2-naphthalen-1-ylpropanoic acid Chemical compound C1=CC=C2C(C(C)(C(O)=O)OC)=CC=CC2=C1 YVWMPILNFZOQSZ-UHFFFAOYSA-N 0.000 abstract 1
- DVQOTDYKJNEHNJ-UHFFFAOYSA-N 2-methoxy-6-prop-2-enylnaphthalene Chemical compound C1=C(CC=C)C=CC2=CC(OC)=CC=C21 DVQOTDYKJNEHNJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal nitrite Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 abstract 1
- 230000027950 fever generation Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 abstract 1
- 229910000000 metal hydroxide Inorganic materials 0.000 abstract 1
- 150000004692 metal hydroxides Chemical class 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86247869A | 1969-09-30 | 1969-09-30 | |
| US86246169A | 1969-09-30 | 1969-09-30 | |
| US86247769A | 1969-09-30 | 1969-09-30 | |
| US86246269A | 1969-09-30 | 1969-09-30 | |
| US85348169A | 1969-09-30 | 1969-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1301442A true GB1301442A (enrdf_load_stackoverflow) | 1972-12-29 |
Family
ID=27542262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1301442D Expired GB1301442A (enrdf_load_stackoverflow) | 1969-09-30 | 1970-01-20 |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1301442A (enrdf_load_stackoverflow) |
-
1970
- 1970-01-20 GB GB1301442D patent/GB1301442A/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |