GB1298529A - Basic esters derived from flouranthene and process for their preparation - Google Patents

Basic esters derived from flouranthene and process for their preparation

Info

Publication number
GB1298529A
GB1298529A GB2301271A GB2301271A GB1298529A GB 1298529 A GB1298529 A GB 1298529A GB 2301271 A GB2301271 A GB 2301271A GB 2301271 A GB2301271 A GB 2301271A GB 1298529 A GB1298529 A GB 1298529A
Authority
GB
United Kingdom
Prior art keywords
basic esters
flouranthene
preparation
nrr
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2301271A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr L Zambeletti SpA
Original Assignee
Dr L Zambeletti SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr L Zambeletti SpA filed Critical Dr L Zambeletti SpA
Publication of GB1298529A publication Critical patent/GB1298529A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/74—Acyl halides containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1298529 Fluoranthene-derived basic esters DR L ZAMBELETTI SpA 19 April 1971 [16 May 1970] 23012/71 Heading C2C The invention comprises compounds of formula Ar-X-CH 2 CH 2 CO 2 Y and their non- toxic acid addition salts, wherein Ar is fluoranthen-8-yl; X is CH 2 or CO; Y is 1-methyl-4- piperidyl or CH 2 CH 2 Z; and Z is NRR<SP>1</SP> (R, R<SP>1</SP> being each C 1-4 alkyl or C 5-6 cycloalkyl, or NRR<SP>1</SP> forming a 5 or 6 membered ring) cyclohexylamino, 4 - pyridyl, 2 - methyl - 6 - pyridyl or These compounds are prepared by reacting (1) Ar-X-CH 2 CH 2 -COCl with YOH at 0-70‹ C. in an aprotic solvent, or (2) or its sodium salt with YCl. Therapeutic compositions for oral or parenteral administration comprise the above basic esters, which have spasmolytic activity.
GB2301271A 1970-05-16 1971-04-19 Basic esters derived from flouranthene and process for their preparation Expired GB1298529A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2473870A IT1044199B (en) 1970-05-16 1970-05-16 BASIC ESTERS OF ACIDS FLUORANTREN RANGE 8 THE BUTIRRICI EQUIPPED WITH ANTISPASTIC PROPERTIES AND PROCESSED FOR THEIR PREPARATION

Publications (1)

Publication Number Publication Date
GB1298529A true GB1298529A (en) 1972-12-06

Family

ID=11214579

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2301271A Expired GB1298529A (en) 1970-05-16 1971-04-19 Basic esters derived from flouranthene and process for their preparation

Country Status (2)

Country Link
GB (1) GB1298529A (en)
IT (1) IT1044199B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215207A1 (en) * 1973-01-12 1974-08-23 Zambeletti Spa L Basic esters of (fluoroanthen-8-yl)-carboxylic acid - antispasmodic agents of low toxicity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215207A1 (en) * 1973-01-12 1974-08-23 Zambeletti Spa L Basic esters of (fluoroanthen-8-yl)-carboxylic acid - antispasmodic agents of low toxicity

Also Published As

Publication number Publication date
IT1044199B (en) 1980-03-20

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee