GB1296431A - - Google Patents

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Publication number
GB1296431A
GB1296431A GB1296431DA GB1296431A GB 1296431 A GB1296431 A GB 1296431A GB 1296431D A GB1296431D A GB 1296431DA GB 1296431 A GB1296431 A GB 1296431A
Authority
GB
United Kingdom
Prior art keywords
alkoxy
formula
treatment
addition salts
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1296431A publication Critical patent/GB1296431A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Abstract

1296431 2 - Phenoxyalkylaminomethyl chromanes WARD BLENKINSOP & CO Ltd 19 April 1971 [26 Jan 1970] 3748/70 Heading C2C Novel compounds of the Formula. (I) where R and R<SP>1</SP> are H, halo, or C 1-2 alkyl or alkoxy, n is an integer from 2 to 6 and R<SP>2</SP> and R<SP>3</SP> are H, or C 1-2 alkoxy, and acid addition salts thereof are obtained by reacting a 2-substituted methyl chromane (II) in which one of X and Z is a halogen atom and the other a primary amino group, the resulting hydrohalide being optionally decomposed by treatment with an acid acceptor, and a salt being formed by treatment with a corresponding acid. Pharmaceutical compositions having hypotensive and adrenolytic and adrenergic blocking properties comprise compounds of Formula (I) and their pharmacologically acceptable acid addition salts together with an inert carrier, preferably for administration in the form of tablets, capsules or suppositories or by the intravenous route.
GB1296431D 1970-01-26 1970-01-26 Expired GB1296431A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB374870 1970-01-26

Publications (1)

Publication Number Publication Date
GB1296431A true GB1296431A (en) 1972-11-15

Family

ID=9764239

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1296431D Expired GB1296431A (en) 1970-01-26 1970-01-26

Country Status (1)

Country Link
GB (1) GB1296431A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans
US4360532A (en) * 1981-01-29 1982-11-23 E. R. Squibb & Sons, Inc. Substituted chromans
US5747528A (en) * 1996-02-21 1998-05-05 Warner-Lambert Company Chroman derivatives as anti-oxidants
WO2003040382A1 (en) * 2001-11-09 2003-05-15 Kaneka Corporation Process for producing optically active chroman derivative and intermediate

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans
FR2498601A1 (en) * 1981-01-29 1982-07-30 Squibb & Sons Inc NOVEL SUBSTITUTED CHROMANS USEFUL AS ANTI-INFLAMMATORY
US4360532A (en) * 1981-01-29 1982-11-23 E. R. Squibb & Sons, Inc. Substituted chromans
US5747528A (en) * 1996-02-21 1998-05-05 Warner-Lambert Company Chroman derivatives as anti-oxidants
WO2003040382A1 (en) * 2001-11-09 2003-05-15 Kaneka Corporation Process for producing optically active chroman derivative and intermediate
EP1445324A1 (en) * 2001-11-09 2004-08-11 Kaneka Corporation Process for producing optically active chroman derivative and intermediate
EP1445324A4 (en) * 2001-11-09 2005-02-16 Kaneka Corp Process for producing optically active chroman derivative and intermediate

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Legal Events

Date Code Title Description
PS Patent sealed
PLE Entries relating assignments, transmissions, licences in the register of patents
PCNP Patent ceased through non-payment of renewal fee