GB1296185A - - Google Patents
Info
- Publication number
- GB1296185A GB1296185A GB1296185DA GB1296185A GB 1296185 A GB1296185 A GB 1296185A GB 1296185D A GB1296185D A GB 1296185DA GB 1296185 A GB1296185 A GB 1296185A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- reaction
- prepared
- benzyl
- pentynoic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1296185 Basic esters of 2-phenyl-4-pentynoic acids DR L ZAMBELETTI SpA 19 April 1971 [13 May 1970] 23013/71 Heading C2C Novel compounds of Formula I wherein R is H or benzyl, Y is-(CH 2 ) n N(R<SP>1</SP>)R<SP>11</SP> where n is 2 or 3 and R<SP>1</SP> and R<SP>11</SP> are C 1-4 alkyl or Y is N-alkyl-4-piperidinyl and acid addition salts thereof are prepared either by reaction of the appropriate alcohol with the 2-phenyl-4- pentynoyl chloride or by reaction of Y-Cl with the 2-phenyl-4-pentynoic acid. 2 - Phenyl - 3 - methyl - 4 - pentynoic acid and the corresponding 2 - benzyl - 2 - phenyl compound are prepared by hydrolysis of the corresponding nitrites the latter of which is obtained by reacting the former with sodamide then benzyl chloride and the former is prepared by reaction of phenylacetonitrile in sodium/ liquid ammonia with 3-bromo-3-methyl-1-pentyne is obtained by action of PBr 3 on the alcohol. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having spasmolytic activity comprise an above novel compound and a carrier or diluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2459170A IT1044196B (en) | 1970-05-13 | 1970-05-13 | BASIC ESTERS OF 2 FENYL 4 PENTINOID ACIDS EQUIPPED WITH ANTI-SPATICAL PROPERTIES AND PROCESS FOR THEIR PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1296185A true GB1296185A (en) | 1972-11-15 |
Family
ID=11214083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1296185D Expired GB1296185A (en) | 1970-05-13 | 1971-04-19 |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB1296185A (en) |
| IT (1) | IT1044196B (en) |
-
1970
- 1970-05-13 IT IT2459170A patent/IT1044196B/en active
-
1971
- 1971-04-19 GB GB1296185D patent/GB1296185A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IT1044196B (en) | 1980-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |