GB1291994A - Anti-viral guanidine compounds - Google Patents
Anti-viral guanidine compoundsInfo
- Publication number
- GB1291994A GB1291994A GB52262/69A GB5226269A GB1291994A GB 1291994 A GB1291994 A GB 1291994A GB 52262/69 A GB52262/69 A GB 52262/69A GB 5226269 A GB5226269 A GB 5226269A GB 1291994 A GB1291994 A GB 1291994A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- imino
- carbon atoms
- compounds
- sulphur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002357 guanidines Chemical class 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- -1 imino radicals Chemical class 0.000 abstract 21
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 12
- 125000004432 carbon atom Chemical group C* 0.000 abstract 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 4
- 239000005864 Sulphur Substances 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- 229910021529 ammonia Inorganic materials 0.000 abstract 4
- 150000003254 radicals Chemical class 0.000 abstract 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000012948 isocyanate Substances 0.000 abstract 3
- 150000002513 isocyanates Chemical class 0.000 abstract 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- JSYGRUBHOCKMGQ-UHFFFAOYSA-N dichloramine Chemical compound ClNCl JSYGRUBHOCKMGQ-UHFFFAOYSA-N 0.000 abstract 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- BCFGMEZQSVGKRJ-UHFFFAOYSA-N N'-(4-chlorophenyl)-3-[(N'-propan-2-ylcarbamimidoyl)amino]benzenecarboximidamide Chemical compound ClC1=CC=C(C=C1)NC(C1=CC(=CC=C1)NC(=N)NC(C)C)=N BCFGMEZQSVGKRJ-UHFFFAOYSA-N 0.000 abstract 1
- PQWPYMAPMRQHIE-UHFFFAOYSA-N N'-(4-chlorophenyl)-4-[(N'-propan-2-ylcarbamimidoyl)amino]benzenecarboximidamide Chemical compound ClC1=CC=C(C=C1)NC(C1=CC=C(C=C1)NC(=N)NC(C)C)=N PQWPYMAPMRQHIE-UHFFFAOYSA-N 0.000 abstract 1
- MDTGCAOXUFJLKI-UHFFFAOYSA-N [4-(diaminomethylideneamino)phenyl]thiourea Chemical compound N(C(=N)N)C1=CC=C(C=C1)NC(=S)N MDTGCAOXUFJLKI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 150000003931 anilides Chemical class 0.000 abstract 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 229940101209 mercuric oxide Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- VBEGHXKAFSLLGE-UHFFFAOYSA-N n-phenylnitramide Chemical compound [O-][N+](=O)NC1=CC=CC=C1 VBEGHXKAFSLLGE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE757956D BE757956A (fr) | 1969-10-24 | Composes antiviraux | |
| GB52262/69A GB1291994A (en) | 1969-10-24 | 1969-10-24 | Anti-viral guanidine compounds |
| ZA706889A ZA706889B (en) | 1969-10-24 | 1970-10-09 | Anti-viral compounds |
| NL7015458A NL7015458A (enrdf_load_stackoverflow) | 1969-10-24 | 1970-10-22 | |
| AT983171A AT304565B (de) | 1969-10-24 | 1970-10-23 | Verfahren zur Herstellung von neuen Guanidin- oder Thioharnstoffderivaten und von deren Säureadditionssalzen |
| DE19702052132 DE2052132A1 (de) | 1969-10-24 | 1970-10-23 | Antivirale Guandidin und Thioharnstoff derivate, Verfahren zu deren Herstellung und Arzneimittel auf dieser Grundlage |
| FR707038434A FR2070161B1 (enrdf_load_stackoverflow) | 1969-10-24 | 1970-10-23 | |
| AT983071A AT303058B (de) | 1969-10-24 | 1970-10-23 | Verfahren zur Herstellung von neuen Guanidin- oder Thioharnstoffderivaten und von deren Säureadditionssalzen |
| AT957670A AT302349B (de) | 1969-10-24 | 1970-10-23 | Verfahren zur Herstellung von neuen Guanidin- oder Thioharnstoffderivaten und von deren Säureadditionssalzen |
| ES384873A ES384873A1 (es) | 1969-10-24 | 1970-10-24 | Procedimiento para la obtencion de derivados de benzamidi- na. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB52262/69A GB1291994A (en) | 1969-10-24 | 1969-10-24 | Anti-viral guanidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1291994A true GB1291994A (en) | 1972-10-04 |
Family
ID=10463239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB52262/69A Expired GB1291994A (en) | 1969-10-24 | 1969-10-24 | Anti-viral guanidine compounds |
Country Status (8)
| Country | Link |
|---|---|
| AT (3) | AT304565B (enrdf_load_stackoverflow) |
| BE (1) | BE757956A (enrdf_load_stackoverflow) |
| DE (1) | DE2052132A1 (enrdf_load_stackoverflow) |
| ES (1) | ES384873A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2070161B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1291994A (enrdf_load_stackoverflow) |
| NL (1) | NL7015458A (enrdf_load_stackoverflow) |
| ZA (1) | ZA706889B (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6229566A (ja) * | 1985-07-30 | 1987-02-07 | Taiyo Yakuhin Kogyo Kk | 新規グアニジノメチル安息香酸誘導体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX3465E (es) * | 1960-10-14 | 1980-09-12 | Wander Ltd Wander Ag Wander S | Procedimiento para la obtencion de ureas n,n'-difenil |
| GB1188956A (en) * | 1967-07-14 | 1970-04-22 | Delalande Sa | N-Substituted Aromatic Amidines and process for obtaining same |
-
0
- BE BE757956D patent/BE757956A/xx unknown
-
1969
- 1969-10-24 GB GB52262/69A patent/GB1291994A/en not_active Expired
-
1970
- 1970-10-09 ZA ZA706889A patent/ZA706889B/xx unknown
- 1970-10-22 NL NL7015458A patent/NL7015458A/xx unknown
- 1970-10-23 AT AT983171A patent/AT304565B/de not_active IP Right Cessation
- 1970-10-23 AT AT957670A patent/AT302349B/de not_active IP Right Cessation
- 1970-10-23 AT AT983071A patent/AT303058B/de not_active IP Right Cessation
- 1970-10-23 DE DE19702052132 patent/DE2052132A1/de active Pending
- 1970-10-23 FR FR707038434A patent/FR2070161B1/fr not_active Expired
- 1970-10-24 ES ES384873A patent/ES384873A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA706889B (en) | 1971-07-28 |
| FR2070161B1 (enrdf_load_stackoverflow) | 1974-06-21 |
| BE757956A (fr) | 1971-04-23 |
| AT304565B (de) | 1973-01-10 |
| AT303058B (de) | 1972-11-10 |
| ES384873A1 (es) | 1973-03-16 |
| AT302349B (de) | 1972-10-10 |
| FR2070161A1 (enrdf_load_stackoverflow) | 1971-09-10 |
| NL7015458A (enrdf_load_stackoverflow) | 1971-04-27 |
| DE2052132A1 (de) | 1971-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |