GB1291684A - THIENO[2,3-e][1,4]DIAZEPIN-2-ONES AND PHARMACEUTICAL PREPARATIONS THEREOF - Google Patents
THIENO[2,3-e][1,4]DIAZEPIN-2-ONES AND PHARMACEUTICAL PREPARATIONS THEREOFInfo
- Publication number
- GB1291684A GB1291684A GB21598/71A GB2159871A GB1291684A GB 1291684 A GB1291684 A GB 1291684A GB 21598/71 A GB21598/71 A GB 21598/71A GB 2159871 A GB2159871 A GB 2159871A GB 1291684 A GB1291684 A GB 1291684A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- benzoylthiophene
- reaction
- diazepin
- thieno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- BCLLRLFMZPPAMJ-UHFFFAOYSA-N 2-azido-N-(3-benzoylthiophen-2-yl)acetamide Chemical compound N(=[N+]=[N-])CC(=O)NC=1SC=CC1C(C1=CC=CC=C1)=O BCLLRLFMZPPAMJ-UHFFFAOYSA-N 0.000 abstract 3
- OYWHIVYACGRJMC-UHFFFAOYSA-N 5-phenyl-1,3-dihydrothieno[2,3-e][1,4]diazepin-2-one Chemical class C1=2C=CSC=2NC(=O)CN=C1C1=CC=CC=C1 OYWHIVYACGRJMC-UHFFFAOYSA-N 0.000 abstract 3
- VXIMIQNIBMDZCM-UHFFFAOYSA-N (2-aminothiophen-3-yl)-phenylmethanone Chemical compound S1C=CC(C(=O)C=2C=CC=CC=2)=C1N VXIMIQNIBMDZCM-UHFFFAOYSA-N 0.000 abstract 2
- URRPWYWSRRYPKA-UHFFFAOYSA-N 2-amino-n-(3-benzoylthiophen-2-yl)acetamide Chemical compound S1C=CC(C(=O)C=2C=CC=CC=2)=C1NC(=O)CN URRPWYWSRRYPKA-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- AVSCRSFXQAVXQJ-UHFFFAOYSA-N N-(3-benzoylthiophen-2-yl)-2-iodoacetamide Chemical compound C(C1=CC=CC=C1)(=O)C1=C(SC=C1)NC(CI)=O AVSCRSFXQAVXQJ-UHFFFAOYSA-N 0.000 abstract 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000010513 Stupor Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 alkyl glycinate Chemical compound 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- UHGWKLDTSABGNF-UHFFFAOYSA-N benzyl N-[2-[(3-benzoylthiophen-2-yl)amino]-2-oxoethyl]carbamate Chemical compound C(C1=CC=CC=C1)OC(=O)NCC(=O)NC=1SC=CC1C(C1=CC=CC=C1)=O UHGWKLDTSABGNF-UHFFFAOYSA-N 0.000 abstract 1
- HJJNNRNPEWJNSR-UHFFFAOYSA-N benzyl n-(2-chloro-2-oxoethyl)carbamate Chemical compound ClC(=O)CNC(=O)OCC1=CC=CC=C1 HJJNNRNPEWJNSR-UHFFFAOYSA-N 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1407070 | 1970-02-17 | ||
| JP45015819A JPS4910955B1 (enrdf_load_stackoverflow) | 1970-02-23 | 1970-02-23 | |
| JP45019403A JPS4940000B1 (enrdf_load_stackoverflow) | 1970-03-07 | 1970-03-07 | |
| JP45056154A JPS4932549B1 (enrdf_load_stackoverflow) | 1970-06-25 | 1970-06-25 | |
| JP45067442A JPS4940238B1 (enrdf_load_stackoverflow) | 1970-07-31 | 1970-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1291684A true GB1291684A (en) | 1972-10-04 |
Family
ID=27519583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21598/71A Expired GB1291684A (en) | 1970-02-17 | 1971-04-19 | THIENO[2,3-e][1,4]DIAZEPIN-2-ONES AND PHARMACEUTICAL PREPARATIONS THEREOF |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3849405A (enrdf_load_stackoverflow) |
| BE (1) | BE763014A (enrdf_load_stackoverflow) |
| CA (1) | CA927388A (enrdf_load_stackoverflow) |
| CH (1) | CH568322A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2107356C3 (enrdf_load_stackoverflow) |
| FR (1) | FR2081520B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1291684A (enrdf_load_stackoverflow) |
| NL (1) | NL175723C (enrdf_load_stackoverflow) |
| SE (1) | SE367415B (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1340227A (en) * | 1970-09-03 | 1973-12-12 | Yoshitomi Pharmaceutical | 5-pyridyl-thieno-2,3-e 1,4-diazepin 2-one derivatives their production and pharmaceutical compositions containing them |
| JPS5418280B2 (enrdf_load_stackoverflow) * | 1971-10-30 | 1979-07-06 | ||
| GB1387783A (en) * | 1972-08-08 | 1975-03-19 | Yoshitomi Pharmaceutical | Thiophene derivatives, method for their preparation and pharmaceutical composition thereof |
| ES412186A1 (es) * | 1973-02-28 | 1976-01-01 | Made Labor Sa | Un procedimiento para la preparacion de derivados de tieno-diazepinona. |
| FR2385721A1 (fr) * | 1977-03-31 | 1978-10-27 | Hexachimie | Cyclopropyl-6 dihydro-1,3 methyl-1 phenyl-5 oxo-2 2 h-thieno (2,3-e) diazepine, son procede de preparation et son application en therapeutique |
| US4992437A (en) * | 1987-12-22 | 1991-02-12 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compounds and their pharmaceutical use |
| WO2014094357A1 (en) * | 2012-12-21 | 2014-06-26 | Abbvie Inc. | Heterocyclic nuclear hormone receptor modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH540247A (de) * | 1967-04-21 | 1973-09-28 | Ciba Geigy Ag | Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen |
| GB1256548A (enrdf_load_stackoverflow) * | 1968-12-10 | 1971-12-08 |
-
1971
- 1971-02-11 CA CA105296A patent/CA927388A/en not_active Expired
- 1971-02-16 BE BE763014A patent/BE763014A/xx not_active IP Right Cessation
- 1971-02-16 SE SE01973/71A patent/SE367415B/xx unknown
- 1971-02-16 CH CH222471A patent/CH568322A5/xx not_active IP Right Cessation
- 1971-02-16 DE DE2107356A patent/DE2107356C3/de not_active Expired
- 1971-02-16 NL NLAANVRAGE7102066,A patent/NL175723C/xx not_active IP Right Cessation
- 1971-02-17 US US00116240A patent/US3849405A/en not_active Expired - Lifetime
- 1971-02-17 FR FR7105383A patent/FR2081520B1/fr not_active Expired
- 1971-04-19 GB GB21598/71A patent/GB1291684A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2107356B2 (de) | 1977-09-22 |
| BE763014A (fr) | 1971-07-16 |
| NL175723C (nl) | 1984-12-17 |
| NL175723B (nl) | 1984-07-16 |
| CH568322A5 (enrdf_load_stackoverflow) | 1975-10-31 |
| DE2107356C3 (de) | 1978-05-03 |
| SE367415B (enrdf_load_stackoverflow) | 1974-05-27 |
| DE2107356A1 (de) | 1971-08-26 |
| US3849405A (en) | 1974-11-19 |
| FR2081520B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| CA927388A (en) | 1973-05-29 |
| NL7102066A (enrdf_load_stackoverflow) | 1971-08-19 |
| FR2081520A1 (enrdf_load_stackoverflow) | 1971-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |