GB1286161A - Pyridoxine mono-esters - Google Patents
Pyridoxine mono-estersInfo
- Publication number
- GB1286161A GB1286161A GB42153/70A GB4215370A GB1286161A GB 1286161 A GB1286161 A GB 1286161A GB 42153/70 A GB42153/70 A GB 42153/70A GB 4215370 A GB4215370 A GB 4215370A GB 1286161 A GB1286161 A GB 1286161A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyridoxine
- mono
- acyl chloride
- salts
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 title abstract 9
- 235000008160 pyridoxine Nutrition 0.000 title abstract 5
- 239000011677 pyridoxine Substances 0.000 title abstract 5
- 229940011671 vitamin b6 Drugs 0.000 title abstract 5
- 150000001263 acyl chlorides Chemical class 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000003158 alcohol group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- AFUOSTONILGUDT-UHFFFAOYSA-N 1-(dimethylamino)ethanol pentanedioic acid Chemical compound C(CCCC(=O)O)(=O)O.CN(C)C(C)O AFUOSTONILGUDT-UHFFFAOYSA-N 0.000 abstract 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- OTCCIMWXFLJLIA-UHFFFAOYSA-N N-acetyl-DL-aspartic acid Natural products CC(=O)NC(C(O)=O)CC(O)=O OTCCIMWXFLJLIA-UHFFFAOYSA-N 0.000 abstract 1
- OTCCIMWXFLJLIA-BYPYZUCNSA-N N-acetyl-L-aspartic acid Chemical compound CC(=O)N[C@H](C(O)=O)CC(O)=O OTCCIMWXFLJLIA-BYPYZUCNSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- HJHRTMIGQLHICJ-UHFFFAOYSA-N butanedioic acid;1-(dimethylamino)ethanol Chemical compound CC(O)N(C)C.OC(=O)CCC(O)=O HJHRTMIGQLHICJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002181 pyridoxine group Chemical group 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MY7500240A MY7500240A (en) | 1970-01-21 | 1975-12-30 | Pyridoxine mono-esters |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB289970 | 1970-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1286161A true GB1286161A (en) | 1972-08-23 |
Family
ID=9748130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42153/70A Expired GB1286161A (en) | 1970-01-21 | 1970-01-21 | Pyridoxine mono-esters |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS4822712B1 (enExample) |
| AT (1) | AT303729B (enExample) |
| BE (1) | BE761534A (enExample) |
| CA (1) | CA969958A (enExample) |
| CH (1) | CH518281A (enExample) |
| ES (1) | ES387410A1 (enExample) |
| FR (2) | FR2081444B1 (enExample) |
| GB (1) | GB1286161A (enExample) |
| NL (1) | NL142332B (enExample) |
| OA (1) | OA03677A (enExample) |
| ZA (1) | ZA708588B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010150261A1 (en) * | 2009-06-25 | 2010-12-29 | Alcobra Ltd. | A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition |
| US8476304B2 (en) | 2007-07-03 | 2013-07-02 | Alcobra Ltd. | Method for decreasing symptoms of alcohol consumption |
| US8889715B2 (en) | 2008-07-29 | 2014-11-18 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate salts |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3735E (fr) * | 1904-08-22 | 1905-02-21 | Jean Fayaud | Couverture des trains en marche et répétition des signaux sur la machine |
-
1970
- 1970-01-21 GB GB42153/70A patent/GB1286161A/en not_active Expired
- 1970-12-21 ZA ZA708588A patent/ZA708588B/xx unknown
- 1970-12-31 JP JP45123806A patent/JPS4822712B1/ja active Pending
-
1971
- 1971-01-12 FR FR7100717A patent/FR2081444B1/fr not_active Expired
- 1971-01-12 CH CH45571A patent/CH518281A/fr not_active IP Right Cessation
- 1971-01-13 BE BE761534A patent/BE761534A/xx not_active IP Right Cessation
- 1971-01-18 OA OA54143A patent/OA03677A/xx unknown
- 1971-01-19 AT AT43671A patent/AT303729B/de not_active IP Right Cessation
- 1971-01-19 ES ES387410A patent/ES387410A1/es not_active Expired
- 1971-01-20 NL NL717100756A patent/NL142332B/xx not_active IP Right Cessation
- 1971-01-21 CA CA103,470A patent/CA969958A/en not_active Expired
-
1972
- 1972-09-06 FR FR7231500A patent/FR2154465B1/fr not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8476304B2 (en) | 2007-07-03 | 2013-07-02 | Alcobra Ltd. | Method for decreasing symptoms of alcohol consumption |
| US9808446B2 (en) | 2007-07-03 | 2017-11-07 | Alcobra Ltd. | Method for decreasing symptoms of alcohol consumption |
| US8889715B2 (en) | 2008-07-29 | 2014-11-18 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate salts |
| US9428458B2 (en) | 2008-07-29 | 2016-08-30 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate-salts |
| WO2010150261A1 (en) * | 2009-06-25 | 2010-12-29 | Alcobra Ltd. | A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition |
| US8710067B2 (en) | 2009-06-25 | 2014-04-29 | Alcobra Ltd. | Method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition |
| EA023758B1 (ru) * | 2009-06-25 | 2016-07-29 | Алкобра Лтд. | Применение метадоксина для лечения синдрома дефицита внимания/гиперактивности (adhd/add) |
Also Published As
| Publication number | Publication date |
|---|---|
| NL142332B (nl) | 1974-06-17 |
| CA969958A (en) | 1975-06-24 |
| BE761534A (fr) | 1971-07-13 |
| FR2081444B1 (enExample) | 1974-09-27 |
| ZA708588B (en) | 1971-09-29 |
| DE2102831B2 (de) | 1975-10-09 |
| JPS4822712B1 (enExample) | 1973-07-07 |
| AT303729B (de) | 1972-12-11 |
| DE2102831A1 (de) | 1971-07-22 |
| ES387410A1 (es) | 1973-05-16 |
| FR2154465A1 (enExample) | 1973-05-11 |
| NL7100756A (enExample) | 1971-07-23 |
| FR2081444A1 (enExample) | 1971-12-03 |
| OA03677A (fr) | 1971-12-24 |
| FR2154465B1 (enExample) | 1975-08-08 |
| CH518281A (fr) | 1972-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |