GB1286161A - Pyridoxine mono-esters - Google Patents

Pyridoxine mono-esters

Info

Publication number
GB1286161A
GB1286161A GB42153/70A GB4215370A GB1286161A GB 1286161 A GB1286161 A GB 1286161A GB 42153/70 A GB42153/70 A GB 42153/70A GB 4215370 A GB4215370 A GB 4215370A GB 1286161 A GB1286161 A GB 1286161A
Authority
GB
United Kingdom
Prior art keywords
pyridoxine
mono
acyl chloride
salts
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB42153/70A
Inventor
Andre Esanu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dEtudes de Produits Chimiques SA
Original Assignee
Societe dEtudes de Produits Chimiques SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dEtudes de Produits Chimiques SA filed Critical Societe dEtudes de Produits Chimiques SA
Publication of GB1286161A publication Critical patent/GB1286161A/en
Priority to MY7500240A priority Critical patent/MY7500240A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1286161 Pyridoxine mono-esters SOC D'ETUDES DE PRODUITS CHIMIQUES 19 April 1971 [21 Jan 1970 3 Sept 1970] 2899/70 and 42153/70 Heading C2V Salts of pyridoxine mono-ester have the formula where A and A<SP>1</SP> are alkylene radicals or divalent amino-substituted aliphatic hydrocarbon radicals, R<SP>1</SP> and R<SP>2</SP> are alkyl radicals or together with the nitrogen atom form a heterocyclic ring, AC is a pharmaceutically acceptable acid, and n is 1, 2 or 3. The compounds are prepared by blocking the two alcohol functions in the 3- and 4- positions of pyridoxine, reacting the compound thus obtained with an acyl chloride of formula to obtain an intermediate of formula removing the blocking group R, e.g. by hydrolysis, and reacting the resulting compound with a pharmaceutically acceptable acid to obtain the addition salt. In examples pyridoxine is reacted with acetone to block the two alcohol functions; the acyl chlorides used are the acyl chloride of dimethylamino ethanol mono-succinate, the acyl chloride of dimethylamino ethanol monoglutarate and the acyl chloride of N-methyl N<SP>1</SP>- ethanol piperazine mono-succinate; the blocked alcohol groups are liberated by hydrolysis with formic acid; and the salts are obtained by reaction with maleic acid and with N-acetyl aspartic acid. The salts may be mixedwith pharma ceutically acceptable diluents and carriers.
GB42153/70A 1970-01-21 1970-01-21 Pyridoxine mono-esters Expired GB1286161A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MY7500240A MY7500240A (en) 1970-01-21 1975-12-30 Pyridoxine mono-esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB289970 1970-01-21

Publications (1)

Publication Number Publication Date
GB1286161A true GB1286161A (en) 1972-08-23

Family

ID=9748130

Family Applications (1)

Application Number Title Priority Date Filing Date
GB42153/70A Expired GB1286161A (en) 1970-01-21 1970-01-21 Pyridoxine mono-esters

Country Status (11)

Country Link
JP (1) JPS4822712B1 (en)
AT (1) AT303729B (en)
BE (1) BE761534A (en)
CA (1) CA969958A (en)
CH (1) CH518281A (en)
ES (1) ES387410A1 (en)
FR (2) FR2081444B1 (en)
GB (1) GB1286161A (en)
NL (1) NL142332B (en)
OA (1) OA03677A (en)
ZA (1) ZA708588B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010150261A1 (en) * 2009-06-25 2010-12-29 Alcobra Ltd. A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition
US8476304B2 (en) 2007-07-03 2013-07-02 Alcobra Ltd. Method for decreasing symptoms of alcohol consumption
US8889715B2 (en) 2008-07-29 2014-11-18 Alcobra Ltd. Substituted pyridoxine-lactam carboxylate salts

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3735E (en) * 1904-08-22 1905-02-21 Jean Fayaud Coverage of running trains and repetition of signals on the machine

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8476304B2 (en) 2007-07-03 2013-07-02 Alcobra Ltd. Method for decreasing symptoms of alcohol consumption
US9808446B2 (en) 2007-07-03 2017-11-07 Alcobra Ltd. Method for decreasing symptoms of alcohol consumption
US8889715B2 (en) 2008-07-29 2014-11-18 Alcobra Ltd. Substituted pyridoxine-lactam carboxylate salts
US9428458B2 (en) 2008-07-29 2016-08-30 Alcobra Ltd. Substituted pyridoxine-lactam carboxylate-salts
WO2010150261A1 (en) * 2009-06-25 2010-12-29 Alcobra Ltd. A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition
US8710067B2 (en) 2009-06-25 2014-04-29 Alcobra Ltd. Method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition
EA023758B1 (en) * 2009-06-25 2016-07-29 Алкобра Лтд. Use of metadoxine for treating attention deficit/hyperactivity disorder (adhd/add)

Also Published As

Publication number Publication date
ES387410A1 (en) 1973-05-16
JPS4822712B1 (en) 1973-07-07
CH518281A (en) 1972-01-31
FR2081444A1 (en) 1971-12-03
CA969958A (en) 1975-06-24
DE2102831B2 (en) 1975-10-09
BE761534A (en) 1971-07-13
DE2102831A1 (en) 1971-07-22
NL142332B (en) 1974-06-17
OA03677A (en) 1971-12-24
FR2154465B1 (en) 1975-08-08
ZA708588B (en) 1971-09-29
AT303729B (en) 1972-12-11
NL7100756A (en) 1971-07-23
FR2154465A1 (en) 1973-05-11
FR2081444B1 (en) 1974-09-27

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee