GB1283434A - Benzodiazepine derivatives, salts thereof and methods of producing them - Google Patents

Benzodiazepine derivatives, salts thereof and methods of producing them

Info

Publication number
GB1283434A
GB1283434A GB06904/70A GB1690470A GB1283434A GB 1283434 A GB1283434 A GB 1283434A GB 06904/70 A GB06904/70 A GB 06904/70A GB 1690470 A GB1690470 A GB 1690470A GB 1283434 A GB1283434 A GB 1283434A
Authority
GB
United Kingdom
Prior art keywords
april
salts
producing
methods
benzodiazepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB06904/70A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2990669A external-priority patent/JPS4826758B1/ja
Priority claimed from JP3295669A external-priority patent/JPS4834748B1/ja
Priority claimed from JP3295569A external-priority patent/JPS493995B1/ja
Priority claimed from JP3720769A external-priority patent/JPS493996B1/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of GB1283434A publication Critical patent/GB1283434A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1283434 Benzodiazepines SUMITOMO CHEMICAL CO Ltd 9 April 1970 [16 April 1969 28 April 1969 (2) 14 May 1969] 16904/70 Heading C2C Compounds of the general formula (X, Y = halogen; R = C 1-4 alkoxy, n = 1-3 or R=C 3-6 cycloalkyl, n = 2, 3) and their acid addition salts are prepared by (a) introduction of the 1-substituent or (b) removing the protecting group(s) from a compound of the formula (Z = protecting system) followed by ring-closure, and optionally followed in either case by salt formation. The above compounds are tranquilizers, sedatives, muscle relaxants, spasmolytics, anticonvulsants and hypnotics and potentiate the activity of hexobarbital. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB06904/70A 1969-04-16 1970-04-09 Benzodiazepine derivatives, salts thereof and methods of producing them Expired GB1283434A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2990669A JPS4826758B1 (en) 1969-04-16 1969-04-16
JP3295669A JPS4834748B1 (en) 1969-04-28 1969-04-28
JP3295569A JPS493995B1 (en) 1969-04-28 1969-04-28
JP3720769A JPS493996B1 (en) 1969-05-14 1969-05-14

Publications (1)

Publication Number Publication Date
GB1283434A true GB1283434A (en) 1972-07-26

Family

ID=27459141

Family Applications (1)

Application Number Title Priority Date Filing Date
GB06904/70A Expired GB1283434A (en) 1969-04-16 1970-04-09 Benzodiazepine derivatives, salts thereof and methods of producing them

Country Status (6)

Country Link
CA (1) CA969941A (en)
DE (1) DE2016385C3 (en)
DK (1) DK137330B (en)
FR (1) FR2042330B1 (en)
GB (1) GB1283434A (en)
NL (1) NL146813B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL131731C (en) * 1965-12-09

Also Published As

Publication number Publication date
FR2042330B1 (en) 1974-04-12
DE2016385A1 (en) 1971-02-18
DE2016385C3 (en) 1980-09-18
NL7005398A (en) 1970-10-20
DK137330B (en) 1978-02-20
CA969941A (en) 1975-06-24
NL146813B (en) 1975-08-15
DK137330C (en) 1978-07-17
FR2042330A1 (en) 1971-02-12
DE2016385B2 (en) 1980-01-10

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years