GB1279842A - Improvements in and relating to tetrahydrobenzodiazepine derivatives preparation - Google Patents

Improvements in and relating to tetrahydrobenzodiazepine derivatives preparation

Info

Publication number
GB1279842A
GB1279842A GB2076369A GB2076369A GB1279842A GB 1279842 A GB1279842 A GB 1279842A GB 2076369 A GB2076369 A GB 2076369A GB 2076369 A GB2076369 A GB 2076369A GB 1279842 A GB1279842 A GB 1279842A
Authority
GB
United Kingdom
Prior art keywords
relating
derivatives preparation
dumex
april
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2076369A
Inventor
Pasquale Domenico Sorrentino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Dumex AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex AS filed Critical Dumex AS
Priority to GB2076369A priority Critical patent/GB1279842A/en
Priority to NO148170A priority patent/NO123856B/no
Priority to CH546246D priority patent/CH546246A/en
Priority to NL7005821A priority patent/NL7005821A/xx
Priority to FI112270A priority patent/FI49967C/en
Priority to SE553070A priority patent/SE378248B/xx
Priority to AT368370A priority patent/AT303044B/en
Publication of GB1279842A publication Critical patent/GB1279842A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1279842 Benzodiazepines DUMEX (DUMEX Ltd) AS 20 April 1970 [23 April 1969] 20763/69 Headings C2B and C2C Benzodiazepine derivatives are prepared by the following routes: (R, R<SP>3</SP>=H, halogen, NO 2 , CF 3 ; R<SP>1,2</SP>=H, C 1-8 alkyl ; R<SP>5</SP>=C 1-8 alkyl; X=halogen; Y = O, (OH) 2 , (C 1-8 alkoxy) 2 ), optionally followed by acid addition salt formation. The sodium borohydride may be replaced by other alkali metal hydrides.
GB2076369A 1969-04-23 1969-04-23 Improvements in and relating to tetrahydrobenzodiazepine derivatives preparation Expired GB1279842A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB2076369A GB1279842A (en) 1969-04-23 1969-04-23 Improvements in and relating to tetrahydrobenzodiazepine derivatives preparation
NO148170A NO123856B (en) 1969-04-23 1970-04-20
CH546246D CH546246A (en) 1969-04-23 1970-04-21 METHOD FOR MANUFACTURING TETRAHYDROBENZODIAZEPINES.
NL7005821A NL7005821A (en) 1969-04-23 1970-04-22
FI112270A FI49967C (en) 1969-04-23 1970-04-22 Process for the preparation of 4-phenyl-1,2,4,5-tetrahydro-1,4-benzodiazepines.
SE553070A SE378248B (en) 1969-04-23 1970-04-22
AT368370A AT303044B (en) 1969-04-23 1970-04-22 Process for the preparation of tetrahydrobenzodiazepines ind from their acid addition salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2076369A GB1279842A (en) 1969-04-23 1969-04-23 Improvements in and relating to tetrahydrobenzodiazepine derivatives preparation

Publications (1)

Publication Number Publication Date
GB1279842A true GB1279842A (en) 1972-06-28

Family

ID=10151248

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2076369A Expired GB1279842A (en) 1969-04-23 1969-04-23 Improvements in and relating to tetrahydrobenzodiazepine derivatives preparation

Country Status (7)

Country Link
AT (1) AT303044B (en)
CH (1) CH546246A (en)
FI (1) FI49967C (en)
GB (1) GB1279842A (en)
NL (1) NL7005821A (en)
NO (1) NO123856B (en)
SE (1) SE378248B (en)

Also Published As

Publication number Publication date
CH546246A (en) 1974-02-28
NL7005821A (en) 1970-10-27
NO123856B (en) 1972-01-24
SE378248B (en) 1975-08-25
AT303044B (en) 1972-11-10
FI49967B (en) 1975-07-31
FI49967C (en) 1975-11-10

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Legal Events

Date Code Title Description
PS Patent sealed
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee