GB1278816A - Improvements in or relating to controlled release pharmaceutical compositions - Google Patents

Improvements in or relating to controlled release pharmaceutical compositions

Info

Publication number
GB1278816A
GB1278816A GB43479/69A GB4347969A GB1278816A GB 1278816 A GB1278816 A GB 1278816A GB 43479/69 A GB43479/69 A GB 43479/69A GB 4347969 A GB4347969 A GB 4347969A GB 1278816 A GB1278816 A GB 1278816A
Authority
GB
United Kingdom
Prior art keywords
acid
drug
maleic
acrylic
chemisorbed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB43479/69A
Inventor
Gilbert Steven Banker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1278816A publication Critical patent/GB1278816A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin

Abstract

1278816 Controlled-release medicaments G S BANKER 2 Sept 1969 [3 Sept 1968] 43479/69 Heading A5B [Also in Division C3] Orally administrable sustained release compositions comprise a drug having an acid or basic functionality and a physiologically harmless carboxylic acid chemisorbed on the particles of a latex of a polymer containing acidic and/or basic groups the functionality of which is complementary to that of the drug and which is hydratable (at least to the extent that it swells) in the gastrointestinal tract. Suitable polymers are those formed by the emulsion polymerisation of such monomers as acrylic, methacrylic, crotonic, itaconic and maleic acids, half esters of maleic acid, maleic anhydride, sulphonated and phosphonated styrene, vinylamine and aminoalkyl esters of the above acids. Copolymerizates thereof, e.g. with vinyl compounds, acrylates, methacrylates and acrylonitrile may also be employed. The acid may be a mono- or polycarboxylic acid e.g. acetic acid, glycine, oxalic, malonic, succinic, glutaric, adipic, maleic, fumaric, citric or tartaric acid and numerous drugs and drug types are mentioned. The compositions may be made by adding solutions of the drug and acid to an emulsion (latex) of the resin. The product may be used as such in a liquid preparation or the resin may be separated e.g. by filtration, centrifugation, spray-drying &c either with or without initial flocculation as by addition of an electrolyte. Specific examples relate to preparations in which the drugs are methapyrilene, chlorpheniramine, phenylephrine, phenylpropanolamine, pyrilamine, atropine and oxytetracycline (all as salts) and phenobarbital, the resins being anionic acrylic copolymers and styrene-acrylic nonionic polymer. A different drug or some of the same drug may be present in the particles which is not chemisorbed but is merely physically entrapped.
GB43479/69A 1968-09-03 1969-09-02 Improvements in or relating to controlled release pharmaceutical compositions Expired GB1278816A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75714268A 1968-09-03 1968-09-03

Publications (1)

Publication Number Publication Date
GB1278816A true GB1278816A (en) 1972-06-21

Family

ID=25046539

Family Applications (1)

Application Number Title Priority Date Filing Date
GB43479/69A Expired GB1278816A (en) 1968-09-03 1969-09-02 Improvements in or relating to controlled release pharmaceutical compositions

Country Status (3)

Country Link
JP (1) JPS56405B1 (en)
GB (1) GB1278816A (en)
IL (1) IL32930A (en)

Also Published As

Publication number Publication date
IL32930A (en) 1973-08-29
JPS56405B1 (en) 1981-01-08
IL32930A0 (en) 1969-11-30

Similar Documents

Publication Publication Date Title
US3608063A (en) Molecular drug entrapment process and compositions
GB1116670A (en) Process for the manufacture of pharmaceutical preparations in bead form
JP4653399B2 (en) Pharmaceutical dosage form and method for producing the same
KR100663663B1 (en) Copolymer for oral or dermal dosage forms
EP0381219B1 (en) Modified release gemfibrozil composition
US3297664A (en) Calcium salts of lightly cross-linked ethylenically unsaturated carboxylic acids anddiethylenically unsaturated aliphatics
US3629392A (en) Entrapment compositions and processes
KR920009404A (en) Gastric Retention Time Delay Antacid
EP0381218B1 (en) Extended release gemfibrozil composition
GB1266400A (en)
GB833458A (en) Drug composition
GB1278816A (en) Improvements in or relating to controlled release pharmaceutical compositions
US3822230A (en) Copolymeric latexes made water-redispersible by presence of six-membered carbocyclic compound having two vicinal carboxyl substituents
US3091574A (en) Tablet disintegrants
ES8106747A1 (en) Aqueous dispersions, their preparation and their use in preparing coating compositions.
GB1155208A (en) Compositions containing Orally Administrable Iron Salts of Carboxyl Group-Containing Polymers
KR850000476A (en) Bead phase polymer and its preparation method
DE801746C (en) Process for the production of granular polymers of vinyl compounds
US5492700A (en) Process and composition for the development of controlled release gemfibrozil dosage form
GB1310656A (en) Process for the manufacture of peptides
USRE28316E (en) Entrapment compositions and processes
US3538216A (en) Injectable compositions of a drug suspended in an emulsion
JPS54112985A (en) Suspension polymerization of vinyl compound
US3073748A (en) Coated medicaments
GB1278817A (en) Improvements in and relating to controlled release pharmaceutical compositions

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee