GB1278272A - Substituted hexahydro-imidazoquinolines - Google Patents

Substituted hexahydro-imidazoquinolines

Info

Publication number
GB1278272A
GB1278272A GB8882/69A GB888269A GB1278272A GB 1278272 A GB1278272 A GB 1278272A GB 8882/69 A GB8882/69 A GB 8882/69A GB 888269 A GB888269 A GB 888269A GB 1278272 A GB1278272 A GB 1278272A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
aryl
substituted
cho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8882/69A
Inventor
Charles Andrew Raymond Baxter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB8882/69A priority Critical patent/GB1278272A/en
Priority to US11308A priority patent/US3668208A/en
Priority to DE19702007345 priority patent/DE2007345A1/en
Priority to FR7006010A priority patent/FR2034556B1/fr
Priority to CH237570A priority patent/CH521979A/en
Priority to JP45014502A priority patent/JPS5016796B1/ja
Publication of GB1278272A publication Critical patent/GB1278272A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1278272 Emidazo[1,5-a]quinoline derivatives PFIZER Ltd 17 Feb 1970 [19 Feb 1969] 8882/69 Heading C2C The invention comprises compounds of formula the C 1-6 alkanoyl esters and C 1-6 alkyl ethers of such compounds containing OH groups, and their pharmaceutically acceptable acid addition salts and N-oxides, wherein R<SP>1</SP> is C 1-6 alkyl (possibly OH- or aryl-substituted) or C 3-6 cycloalkyl, R<SP>2</SP> is Me, CH 2 OH or CHO, R<SP>3</SP> is NO 2 , CN or halogen, R<SP>4</SP> and R<SP>5</SP> are each H or C 1-6 alkyl, and R<SP>6</SP> is H, C 1-6 alkyl (possibly aryl-substituted) or aryl. The esters and N-oxides are prepared by known methods; otherwise these compounds are prepared by reacting the corresponding 2 - R<SP>1</SP>NHCH 2 - 1,2,3,4 - tetrahydroquinoline with R<SP>6</SP>CHO. Therapeutic compositions for the treatment of schistosomiasis by oral or parenteral administration comprise compounds of the above formula or their stated derivatives.
GB8882/69A 1969-02-19 1969-02-19 Substituted hexahydro-imidazoquinolines Expired GB1278272A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB8882/69A GB1278272A (en) 1969-02-19 1969-02-19 Substituted hexahydro-imidazoquinolines
US11308A US3668208A (en) 1969-02-19 1970-02-13 Hexahydro imidazoquinolines
DE19702007345 DE2007345A1 (en) 1969-02-19 1970-02-18 New substituted hexahydroimidazoquinolines and their acid addition salts
FR7006010A FR2034556B1 (en) 1969-02-19 1970-02-19
CH237570A CH521979A (en) 1969-02-19 1970-02-19 Process for the preparation of substituted hexahydroimidazoquinolines
JP45014502A JPS5016796B1 (en) 1969-02-19 1970-02-19

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8882/69A GB1278272A (en) 1969-02-19 1969-02-19 Substituted hexahydro-imidazoquinolines

Publications (1)

Publication Number Publication Date
GB1278272A true GB1278272A (en) 1972-06-21

Family

ID=9861114

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8882/69A Expired GB1278272A (en) 1969-02-19 1969-02-19 Substituted hexahydro-imidazoquinolines

Country Status (6)

Country Link
US (1) US3668208A (en)
JP (1) JPS5016796B1 (en)
CH (1) CH521979A (en)
DE (1) DE2007345A1 (en)
FR (1) FR2034556B1 (en)
GB (1) GB1278272A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001129A (en) * 1987-12-21 1991-03-19 Delalande S.A. Oxazoloquinoline compounds and therapeutic application thereof

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
US3917610A (en) * 1972-06-30 1975-11-04 Chinoin Gyogyszer Es Vegyeszet Amino-imidazo and amino-pyrazolo-isoquinolines and process for the preparation thereof
US3901897A (en) * 1972-10-05 1975-08-26 Squibb & Sons Inc 1,2,3,4,4a,5,6,7-octahydro-7-aryl-isoquinolines and derivatives thereof
JPS5227199U (en) * 1975-08-19 1977-02-25
US4129567A (en) * 1976-08-06 1978-12-12 Pfizer Inc. Quaternary salts as hypoglycemic agents
US4075343A (en) * 1976-09-13 1978-02-21 Pfizer Inc. Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
ES2123836T3 (en) * 1993-11-19 1999-01-16 Upjohn Co IMIDAZO (1,5-A) QUINOLEINAS FOR THE TREATMENT OF ANXIETY AND SLEEP DISORDERS.
EP0954899A2 (en) * 1997-01-24 1999-11-10 Fische, LLC High efficiency power converter
CN117700413A (en) * 2024-02-05 2024-03-15 湖南工程学院 Hexahydroimidazo [2,1-a ] isoquinoline derivative and synthesis method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3329620A (en) * 1963-04-01 1967-07-04 Hooker Chemical Corp Novel phosphorus sulfide product and method for its manufacture
GB1011311A (en) * 1963-07-04 1965-11-24 Parke Davis & Co Antiparasitic compositions and use thereof
GB1050901A (en) * 1964-02-06
GB1166538A (en) * 1967-06-10 1969-10-08 Pfizer Ltd Substituted Tetrahydroquinolines
US3454579A (en) * 1967-08-17 1969-07-08 American Cyanamid Co Imidazo(1,5-a)quinolin-1-one and thione derivatives
US3565902A (en) * 1967-09-15 1971-02-23 American Cyanamid Co 1,2-dihydro-3h-imidazo(1,5-a)indol-3-ones and 3-thiones
US3557120A (en) * 1969-05-21 1971-01-19 Sterling Drug Inc Hexahydroimidazoisoquinolines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001129A (en) * 1987-12-21 1991-03-19 Delalande S.A. Oxazoloquinoline compounds and therapeutic application thereof

Also Published As

Publication number Publication date
JPS5016796B1 (en) 1975-06-16
FR2034556A1 (en) 1970-12-11
CH521979A (en) 1972-04-30
DE2007345A1 (en) 1970-09-17
FR2034556B1 (en) 1974-04-12
US3668208A (en) 1972-06-06

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee