GB1277137A - New crystalline cephalosporin and processes for preparing same - Google Patents
New crystalline cephalosporin and processes for preparing sameInfo
- Publication number
- GB1277137A GB1277137A GB1888370A GB1888370A GB1277137A GB 1277137 A GB1277137 A GB 1277137A GB 1888370 A GB1888370 A GB 1888370A GB 1888370 A GB1888370 A GB 1888370A GB 1277137 A GB1277137 A GB 1277137A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cephalexin
- monohydrate
- crystalline
- water
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 abstract 6
- 229940106164 cephalexin Drugs 0.000 abstract 5
- 229940047526 cephalexin monohydrate Drugs 0.000 abstract 5
- YGZIWEZFFBPCLN-UHFFFAOYSA-N n,3-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine Chemical compound OOC1CCOP(=O)(NCCCl)N1CCCl YGZIWEZFFBPCLN-UHFFFAOYSA-N 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- AVGYWQBCYZHHPN-DLFVXPSJSA-N O.N[C@@H](C(=O)NC1[C@@H]2N(C(=C(CS2)C)C(=O)O)C1=O)C1=CC=CC=C1 Chemical compound O.N[C@@H](C(=O)NC1[C@@H]2N(C(=C(CS2)C)C(=O)O)C1=O)C1=CC=CC=C1 AVGYWQBCYZHHPN-DLFVXPSJSA-N 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81805769A | 1969-04-21 | 1969-04-21 | |
| US81812569A | 1969-04-21 | 1969-04-21 | |
| US81813869A | 1969-04-21 | 1969-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1277137A true GB1277137A (en) | 1972-06-07 |
Family
ID=27420121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1888370A Expired GB1277137A (en) | 1969-04-21 | 1970-04-21 | New crystalline cephalosporin and processes for preparing same |
Country Status (5)
| Country | Link |
|---|---|
| CY (1) | CY709A (enrdf_load_stackoverflow) |
| FR (1) | FR2042353B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1277137A (enrdf_load_stackoverflow) |
| MY (1) | MY7300495A (enrdf_load_stackoverflow) |
| NL (1) | NL149810B (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1143942B (it) * | 1980-04-23 | 1986-10-29 | Manetti & Roberts Italo Brit | Picolilammide idrata di acido isoftalico ad azione antiaggregante piastrinica antitrombinica ed anticoagulante e procedimento per la sua preparazione |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3502663A (en) * | 1969-04-21 | 1970-03-24 | Lilly Co Eli | Crystalline cephalosporin,method for its manufacture |
-
1970
- 1970-04-20 NL NL7005700A patent/NL149810B/xx not_active IP Right Cessation
- 1970-04-21 FR FR7014400A patent/FR2042353B1/fr not_active Expired
- 1970-04-21 GB GB1888370A patent/GB1277137A/en not_active Expired
-
1973
- 1973-10-01 CY CY70973A patent/CY709A/xx unknown
- 1973-12-30 MY MY7300495A patent/MY7300495A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2042353B1 (enrdf_load_stackoverflow) | 1974-05-24 |
| DE2019145A1 (de) | 1970-12-03 |
| MY7300495A (en) | 1973-12-31 |
| NL149810B (nl) | 1976-06-15 |
| NL7005700A (enrdf_load_stackoverflow) | 1970-10-23 |
| CY709A (en) | 1973-10-01 |
| DE2019145B2 (de) | 1977-02-24 |
| FR2042353A1 (enrdf_load_stackoverflow) | 1971-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746D | Case decided by the comptroller (sect. 46(3)/1977) | ||
| 746A | Appeal to the patents court (sect. 46/1977) | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| 746B | Proceeding under section 46(3) patents act 1977 | ||
| PE20 | Patent expired after termination of 20 years |