GB1277137A - New crystalline cephalosporin and processes for preparing same - Google Patents

New crystalline cephalosporin and processes for preparing same

Info

Publication number
GB1277137A
GB1277137A GB1888370A GB1888370A GB1277137A GB 1277137 A GB1277137 A GB 1277137A GB 1888370 A GB1888370 A GB 1888370A GB 1888370 A GB1888370 A GB 1888370A GB 1277137 A GB1277137 A GB 1277137A
Authority
GB
United Kingdom
Prior art keywords
cephalexin
monohydrate
crystalline
water
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1888370A
Inventor
Earle Marvin Van Heyningen
Albert Johnson Barnes
Ralph Robert Pfeiffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1277137A publication Critical patent/GB1277137A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1277137 Crystalline cephalexin monohydrate ELI LILLY & CO 21 April 1970 [21 April 1969 (3)] 18883/70 Heading C2A Crystalline cephalexin (7-(D-α-aminophenylacetamido) - 3 - methyl - 3 - cephem - 4 - carboxylic acid) monohydrate, having characteristic X-ray diffraction data and being in the form of dense, stable, non-hygroscopic crystals, may be prepared by (a) treating an aqueous solution of a cephalexin acid addition salt at from 58‹ to 75‹ C. with sufficient water-soluble base to convert the cephalexin salt to cephalexin in its zwitterion form thereby precipitating crystalline cephalexin monohydrate which is separated from the aqueous medium, (b) suspending cephalexin or an acid salt thereof in an aqueous solution containing sufficient quantity of a strong acid to dissolve the antibiotic at above 58‹ C., adding a water-soluble base to precipitate cephalexin monohydrate which is then separated, or (c) co-mingling cephalexin with 20 to 50% of its dry weight of water at room temperature and drying the resulting crystalline cephalexin monohydrate to 4 to 8% water content. Pharmaceutical compositions having antibiotic activity comprise the above crystalline cephalexin monohydrate and a pharmaceutical carrier. Reference has been directed by the Comptroller to Specification 1,174,335.
GB1888370A 1969-04-21 1970-04-21 New crystalline cephalosporin and processes for preparing same Expired GB1277137A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81813869A 1969-04-21 1969-04-21
US81805769A 1969-04-21 1969-04-21
US81812569A 1969-04-21 1969-04-21

Publications (1)

Publication Number Publication Date
GB1277137A true GB1277137A (en) 1972-06-07

Family

ID=27420121

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1888370A Expired GB1277137A (en) 1969-04-21 1970-04-21 New crystalline cephalosporin and processes for preparing same

Country Status (5)

Country Link
CY (1) CY709A (en)
FR (1) FR2042353B1 (en)
GB (1) GB1277137A (en)
MY (1) MY7300495A (en)
NL (1) NL149810B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1143942B (en) * 1980-04-23 1986-10-29 Manetti & Roberts Italo Brit PICOLYLAMIDE HYDRATED ISOPHTHALIC ACID WITH ANTI-AGGREGATING, ANTI-THROMBINIC AND ANTI-AGULANT PLASTIC ACTION AND PROCEDURE FOR ITS PREPARATION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture

Also Published As

Publication number Publication date
FR2042353B1 (en) 1974-05-24
DE2019145B2 (en) 1977-02-24
NL7005700A (en) 1970-10-23
CY709A (en) 1973-10-01
DE2019145A1 (en) 1970-12-03
MY7300495A (en) 1973-12-31
NL149810B (en) 1976-06-15
FR2042353A1 (en) 1971-02-12

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Legal Events

Date Code Title Description
PS Patent sealed
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746D Case decided by the comptroller (sect. 46(3)/1977)
746A Appeal to the patents court (sect. 46/1977)
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
PE20 Patent expired after termination of 20 years