GB1273916A - Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents - Google Patents
Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agentsInfo
- Publication number
- GB1273916A GB1273916A GB3680870A GB3680870A GB1273916A GB 1273916 A GB1273916 A GB 1273916A GB 3680870 A GB3680870 A GB 3680870A GB 3680870 A GB3680870 A GB 3680870A GB 1273916 A GB1273916 A GB 1273916A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- novel
- analgesic
- quinazolinones
- dimethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,273,916. 6,7-Dimethoxy quinazolinones. PFIZER Inc. 29 July, 1970 [7-April, 1970], No. 36808/70. Heading C2C. Novel 6,7-dimethoxy quinazolinones of the Formula I wherein Z is CN, COR, COCF 3 , CONRR<SP>1</SP> or COOR except Z is not COOH and R 1 , R 2 , R, R<SP>1</SP> are hydrogen or C 1-4 alkyl may be prepared by reducing a compound II to produce the compound which is condensed with Z-halide alone or Z- OR in the presence of a base to give I. The compound II may be prepared by condensing an NN<SP>1</SP>-disubstituted amide with a 4,5-dimethoxyanthranilic ester in the presence of phosphorous oxychloride, thionyl chloride or phosgene, followed by cyclization of the amidino product with an amine R 1 NH 2 , where R 3 and R 4 are typically lower alkyl to give II. Pharmaceutical compositions of .1 with the usual excipients show analgesic and tranquillizer activity when administered orally or parenterally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2640670A | 1970-04-07 | 1970-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1273916A true GB1273916A (en) | 1972-05-10 |
Family
ID=21831651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3680870A Expired GB1273916A (en) | 1970-04-07 | 1970-07-29 | Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS502992B1 (en) |
BE (1) | BE765343A (en) |
CH (1) | CH522654A (en) |
DE (1) | DE2116079C3 (en) |
ES (1) | ES389924A1 (en) |
FR (1) | FR2092015B1 (en) |
GB (1) | GB1273916A (en) |
MY (1) | MY7400194A (en) |
NL (1) | NL141872B (en) |
SE (1) | SE378595B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59175170U (en) * | 1983-05-09 | 1984-11-22 | 日本碍子株式会社 | Oxygen concentration detector with heater |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3092631A (en) * | 1963-06-04 | Y-chloro-z-lower alkyl-i | ||
CH474525A (en) * | 1967-06-20 | 1969-06-30 | S Chimiques Et Pharma Seceph S | Process for the preparation of novel quinazoline derivatives |
-
1970
- 1970-07-29 GB GB3680870A patent/GB1273916A/en not_active Expired
-
1971
- 1971-04-02 DE DE19712116079 patent/DE2116079C3/en not_active Expired
- 1971-04-05 CH CH488871A patent/CH522654A/en not_active IP Right Cessation
- 1971-04-05 ES ES389924A patent/ES389924A1/en not_active Expired
- 1971-04-06 BE BE765343A patent/BE765343A/en unknown
- 1971-04-06 NL NL7104580A patent/NL141872B/en not_active IP Right Cessation
- 1971-04-07 SE SE460571A patent/SE378595B/xx unknown
- 1971-04-07 JP JP2111871A patent/JPS502992B1/ja active Pending
- 1971-04-07 FR FR7112339A patent/FR2092015B1/fr not_active Expired
-
1974
- 1974-12-30 MY MY7400194A patent/MY7400194A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NL141872B (en) | 1974-04-16 |
FR2092015A1 (en) | 1972-01-21 |
ES389924A1 (en) | 1973-06-01 |
DE2116079C3 (en) | 1975-02-20 |
DE2116079A1 (en) | 1972-02-17 |
DE2116079B2 (en) | 1974-06-12 |
CH522654A (en) | 1972-06-30 |
MY7400194A (en) | 1974-12-31 |
JPS502992B1 (en) | 1975-01-30 |
FR2092015B1 (en) | 1975-01-17 |
NL7104580A (en) | 1971-10-11 |
BE765343A (en) | 1971-10-06 |
SE378595B (en) | 1975-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |