GB1266587A - - Google Patents
Info
- Publication number
- GB1266587A GB1266587A GB1266587DA GB1266587A GB 1266587 A GB1266587 A GB 1266587A GB 1266587D A GB1266587D A GB 1266587DA GB 1266587 A GB1266587 A GB 1266587A
- Authority
- GB
- United Kingdom
- Prior art keywords
- azetidinol
- compounds
- give
- phenyl
- benzoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 230000005494 condensation Effects 0.000 abstract 3
- 238000009833 condensation Methods 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- BSGLMZJRZWDLPH-UHFFFAOYSA-N (1-benzoylazetidin-3-yl) benzoate Chemical compound C(C1=CC=CC=C1)(=O)N1CC(C1)OC(C1=CC=CC=C1)=O BSGLMZJRZWDLPH-UHFFFAOYSA-N 0.000 abstract 1
- LZXZKGIUNYSRJR-UHFFFAOYSA-N (3-hydroxy-3-phenylazetidin-1-yl)-phenylmethanone Chemical compound C1C(O)(C=2C=CC=CC=2)CN1C(=O)C1=CC=CC=C1 LZXZKGIUNYSRJR-UHFFFAOYSA-N 0.000 abstract 1
- MQPNDHHRMVRTCE-UHFFFAOYSA-N (3-hydroxyazetidin-1-yl)-phenylmethanone Chemical compound C1C(O)CN1C(=O)C1=CC=CC=C1 MQPNDHHRMVRTCE-UHFFFAOYSA-N 0.000 abstract 1
- FCWANJOYOGQLDS-UHFFFAOYSA-N 1-benzoylazetidin-3-one Chemical compound C=1C=CC=CC=1C(=O)N1CC(=O)C1 FCWANJOYOGQLDS-UHFFFAOYSA-N 0.000 abstract 1
- ZQQSYPZAPHRXRY-UHFFFAOYSA-N 1-hydroxyazetidine Chemical class ON1CCC1 ZQQSYPZAPHRXRY-UHFFFAOYSA-N 0.000 abstract 1
- QHAYHIACTRSRBO-UHFFFAOYSA-N 3-phenyl-1-(1-phenylethyl)azetidin-3-ol Chemical compound CC(N1CC(O)(C1)C1=CC=CC=C1)C1=CC=CC=C1 QHAYHIACTRSRBO-UHFFFAOYSA-N 0.000 abstract 1
- BCCJGJCXMIOABO-UHFFFAOYSA-N 3-phenylazetidin-3-ol Chemical compound C=1C=CC=CC=1C1(O)CNC1 BCCJGJCXMIOABO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- GMWFCJXSQQHBPI-UHFFFAOYSA-N azetidin-3-ol Chemical compound OC1CNC1 GMWFCJXSQQHBPI-UHFFFAOYSA-N 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- KXARYBXYBGQZCM-UHFFFAOYSA-N n-methyl-n-phenacylbenzamide Chemical compound C=1C=CC=CC=1C(=O)N(C)CC(=O)C1=CC=CC=C1 KXARYBXYBGQZCM-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74120568A | 1968-06-28 | 1968-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1266587A true GB1266587A (enrdf_load_stackoverflow) | 1972-03-15 |
Family
ID=24979786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1266587D Expired GB1266587A (enrdf_load_stackoverflow) | 1968-06-28 | 1969-06-27 |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE735313A (enrdf_load_stackoverflow) |
| CA (1) | CA957382A (enrdf_load_stackoverflow) |
| CH (2) | CH511227A (enrdf_load_stackoverflow) |
| DE (1) | DE1932985A1 (enrdf_load_stackoverflow) |
| DK (1) | DK122126B (enrdf_load_stackoverflow) |
| ES (4) | ES368859A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2014404A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1266587A (enrdf_load_stackoverflow) |
| NL (1) | NL6909923A (enrdf_load_stackoverflow) |
| NO (1) | NO128960B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010058017A1 (en) * | 2008-11-24 | 2010-05-27 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1332511A (fr) * | 1959-12-09 | 1963-07-19 | Lepetit Spa | Procédé pour la préparation de nouvelles n-alkylazétidines |
-
1969
- 1969-06-26 CH CH983869A patent/CH511227A/de not_active IP Right Cessation
- 1969-06-26 CH CH899671D patent/CH524598A/de not_active IP Right Cessation
- 1969-06-27 FR FR6921710A patent/FR2014404A1/fr not_active Withdrawn
- 1969-06-27 DK DK351069A patent/DK122126B/da unknown
- 1969-06-27 NL NL6909923A patent/NL6909923A/xx unknown
- 1969-06-27 BE BE735313D patent/BE735313A/xx unknown
- 1969-06-27 GB GB1266587D patent/GB1266587A/en not_active Expired
- 1969-06-27 ES ES368859A patent/ES368859A1/es not_active Expired
- 1969-06-27 CA CA055,643A patent/CA957382A/en not_active Expired
- 1969-06-27 NO NO269069A patent/NO128960B/no unknown
- 1969-06-28 DE DE19691932985 patent/DE1932985A1/de active Pending
-
1971
- 1971-03-01 ES ES388754A patent/ES388754A1/es not_active Expired
- 1971-03-01 ES ES388753A patent/ES388753A1/es not_active Expired
- 1971-03-01 ES ES388752A patent/ES388752A1/es not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010058017A1 (en) * | 2008-11-24 | 2010-05-27 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
| CN102224135A (zh) * | 2008-11-24 | 2011-10-19 | Nsab神经研究瑞典公司分公司 | 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物 |
| JP2012509860A (ja) * | 2008-11-24 | 2012-04-26 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | 皮質のカテコールアミン作動性神経伝達のモジュレーターとして有用な新規な３−フェニル−アゼチジン誘導体 |
| US8586572B2 (en) | 2008-11-24 | 2013-11-19 | Integrative Research Laboratories Sweden Ab | 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
Also Published As
| Publication number | Publication date |
|---|---|
| ES368859A1 (es) | 1971-07-16 |
| BE735313A (enrdf_load_stackoverflow) | 1969-12-29 |
| DE1932985A1 (de) | 1970-01-02 |
| ES388754A1 (es) | 1973-05-16 |
| CA957382A (en) | 1974-11-05 |
| DK122126B (da) | 1972-01-24 |
| CH511227A (de) | 1971-08-15 |
| NL6909923A (enrdf_load_stackoverflow) | 1969-12-30 |
| NO128960B (enrdf_load_stackoverflow) | 1974-02-04 |
| ES388753A1 (es) | 1973-05-16 |
| FR2014404A1 (enrdf_load_stackoverflow) | 1970-04-17 |
| CH524598A (de) | 1972-06-30 |
| ES388752A1 (es) | 1973-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |