GB1264580A - - Google Patents

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Publication number
GB1264580A
GB1264580A GB1264580DA GB1264580A GB 1264580 A GB1264580 A GB 1264580A GB 1264580D A GB1264580D A GB 1264580DA GB 1264580 A GB1264580 A GB 1264580A
Authority
GB
United Kingdom
Prior art keywords
sept
thiamine
prepared
examples
carriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1264580A publication Critical patent/GB1264580A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols

Abstract

1,264,580. Thiamine derivatives. F. HOFFMANN-LA ROCHE & CO. A.G. 15 Sept., 1970 [18 Sept., 1969], No. 44041/70. Heading C2V. The invention comprises thiamine derivatives of formulae and their salts with pharmaceutically acceptable acids and bases, having Vitamin B 1 activity. They are prepared by reacting thiamine O- phosphate with CH 3 -O-Z-COOH or a functional derivative thereof, where Z is 1,4- butylene or 1,4-phenylene, in an alkaline medium and, if desired, converting the product into a salt. Examples are given. The above compounds may be used in medicinal compositions with suitable carriers. In examples, tablets are prepared from compounds of the invention, together with lactose, corn starch, polyvinylpyrrolidone, talc and magnesium stearate. Other carriers are mentioned.
GB1264580D 1969-09-18 1970-09-15 Expired GB1264580A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1407069A CH523891A (en) 1969-09-18 1969-09-18 Process for the preparation of new 4-amino-2-methyl-pyrimidines substituted in the 5-position

Publications (1)

Publication Number Publication Date
GB1264580A true GB1264580A (en) 1972-02-23

Family

ID=4397708

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1264580D Expired GB1264580A (en) 1969-09-18 1970-09-15

Country Status (9)

Country Link
AU (1) AU1936070A (en)
BE (1) BE756255A (en)
CH (1) CH523891A (en)
DE (1) DE2043536A1 (en)
FR (1) FR2070078A1 (en)
GB (1) GB1264580A (en)
IL (1) IL35204A0 (en)
NL (1) NL7012253A (en)
ZA (1) ZA705839B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111478A (en) * 2017-06-26 2019-01-01 上海日馨生物科技有限公司 Benfotiamine derivative, preparation method and its pharmaceutical composition
CN111233925A (en) * 2018-11-28 2020-06-05 上海日馨生物科技有限公司 Thiamine compound, preparation method and pharmaceutical composition thereof
US10947258B1 (en) 2019-08-23 2021-03-16 Shanghai Rixin Biotechnology Co., Ltd. Benfotiamine derivatives, method for preparing the same and pharmaceutical composition comprising the same
WO2023088457A1 (en) * 2021-11-22 2023-05-25 上海日馨医药科技股份有限公司 Solid form of benfotiamine derivative, and preparation method therefor and use thereof

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111478A (en) * 2017-06-26 2019-01-01 上海日馨生物科技有限公司 Benfotiamine derivative, preparation method and its pharmaceutical composition
CN109111478B (en) * 2017-06-26 2021-02-26 上海日馨生物科技有限公司 Benfotiamine derivative, preparation method and pharmaceutical composition thereof
CN112898342A (en) * 2017-06-26 2021-06-04 上海日馨生物科技有限公司 Benfotiamine derivative, preparation method and pharmaceutical composition thereof
CN112933101A (en) * 2017-06-26 2021-06-11 上海日馨生物科技有限公司 Benfotiamine derivative, preparation method and pharmaceutical composition thereof
CN111233925A (en) * 2018-11-28 2020-06-05 上海日馨生物科技有限公司 Thiamine compound, preparation method and pharmaceutical composition thereof
CN111233925B (en) * 2018-11-28 2021-03-26 上海日馨生物科技有限公司 Thiamine compound, preparation method and pharmaceutical composition thereof
JP2022511468A (en) * 2018-11-28 2022-01-31 上海日馨医▲薬▼科技股▲分▼有限公司 Thiamine compound, production method and pharmaceutical composition thereof
EP3889160A4 (en) * 2018-11-28 2022-07-27 Shanghai Raising Pharmaceutical Co., Ltd. Thiamine compound, preparation method and pharmaceutical composition thereof
US11591354B2 (en) 2018-11-28 2023-02-28 Shanghai Raising Pharmaceutical Co., Ltd. Thiamine compound, preparation method and pharmaceutical composition thereof
US10947258B1 (en) 2019-08-23 2021-03-16 Shanghai Rixin Biotechnology Co., Ltd. Benfotiamine derivatives, method for preparing the same and pharmaceutical composition comprising the same
US11820787B2 (en) 2019-08-23 2023-11-21 Shanghai Raising Pharmaceutical Co., Ltd. Benfotiamine derivatives in the treatment of alzheimer's disease
WO2023088457A1 (en) * 2021-11-22 2023-05-25 上海日馨医药科技股份有限公司 Solid form of benfotiamine derivative, and preparation method therefor and use thereof

Also Published As

Publication number Publication date
NL7012253A (en) 1971-03-22
AU1936070A (en) 1972-03-09
FR2070078A1 (en) 1971-09-10
CH523891A (en) 1972-06-15
BE756255A (en) 1971-03-17
ZA705839B (en) 1971-04-28
DE2043536A1 (en) 1971-05-19
IL35204A0 (en) 1970-11-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees