GB1254465A - Composition for inhibiting anomalous deposition and mobilization of calcium phosphate in human tissue - Google Patents
Composition for inhibiting anomalous deposition and mobilization of calcium phosphate in human tissueInfo
- Publication number
- GB1254465A GB1254465A GB58821/68A GB5882168A GB1254465A GB 1254465 A GB1254465 A GB 1254465A GB 58821/68 A GB58821/68 A GB 58821/68A GB 5882168 A GB5882168 A GB 5882168A GB 1254465 A GB1254465 A GB 1254465A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carrier
- mobilization
- human tissue
- ammonium
- admixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002547 anomalous effect Effects 0.000 title abstract 2
- 230000008021 deposition Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229910000389 calcium phosphate Inorganic materials 0.000 title 1
- 239000001506 calcium phosphate Substances 0.000 title 1
- 235000011010 calcium phosphates Nutrition 0.000 title 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title 1
- -1 phenethenyl Chemical group 0.000 abstract 3
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 229910052738 indium Inorganic materials 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229910052718 tin Inorganic materials 0.000 abstract 1
- 125000005209 triethanolammonium group Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1,254,465. Pharmaceutical compositions containing polyphosphonates. PROCTER & GAMBLE CO. 11 Dec., 1968 [11 Dec., 1967; 1 April, 1968], No. 58821/68. Heading A5B. Pharmaceutical compositions for inhibiting anomalous deposition and mobilization of calcium and phosphate in human tissue comprise one or more polyphosphonates of the formulae: in which R 1 and R 2 are each H or -CH 2 OH; n is an integer from 3 to 10; R 3 is H, alkyl, cycloalkyl, alkenyl, aryl, phenethenyl, benzyl, halogen, amino, substituted a m i n o , -CH 2 COOH, -CH 2 PO 3 H 2 , -CH(PO 3 H 2 ) (OH) or -CH 2 CH (PO 3 H 2 ) 2 and R 4 is H, alkyl, amino, benzyl, halogen, -OH, -CH 2 COOH, -CH 2 PO 3 H 2 or -CH 2 CH 2 PO 3 H 2 or a pharmaceutically acceptable salt thereof in admixture with a solid or liquid pharmaceutically acceptable carrier, which carrier is not water alone and does not include a phenolic or quaternary ammonium bactericide or more than 10% by weight of the active compound, of a wetting agent. Suitable salts include alkali metal (e.g. Na, K), alkaline earth metal (e.g. Ca, Mg), non-toxic heavy metal (e.g. Sn, In), ammonium and substituted ammonium (e.g. mono-, di- and triethanolammonium) salts. Ethane-1-hydroxy-1, 1-diphosphonic acid (also known as 1-hydroxyethylidene diphosphonic acid) is the preferred active compound. The compositions may be administered orally, parenterally or rectally in unit dosage forms comprising tablets, suppositories, pills, dragees, wrapped powders, cachets, sachets, capsules, ampoules or granules. A medicament in dosage unit form may comprise the polyphosphonate(s) alone or in admixture with a carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68929067A | 1967-12-11 | 1967-12-11 | |
| US71799568A | 1968-04-01 | 1968-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1254465A true GB1254465A (en) | 1971-11-24 |
Family
ID=27104378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB58822/68A Expired GB1254466A (en) | 1967-12-11 | 1968-12-11 | Pharmaceutical methods and compositions |
| GB58821/68A Expired GB1254465A (en) | 1967-12-11 | 1968-12-11 | Composition for inhibiting anomalous deposition and mobilization of calcium phosphate in human tissue |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB58822/68A Expired GB1254466A (en) | 1967-12-11 | 1968-12-11 | Pharmaceutical methods and compositions |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT307135B (en) |
| BE (1) | BE725208A (en) |
| CA (1) | CA946290A (en) |
| DE (1) | DE1813659C3 (en) |
| ES (1) | ES361297A1 (en) |
| GB (2) | GB1254466A (en) |
| NL (1) | NL163719C (en) |
| PH (1) | PH9776A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2118042A (en) * | 1982-04-15 | 1983-10-26 | Gentili Ist Spa | Pharmaceutical compositions containing biphosphonic acids |
| US4927814A (en) * | 1986-07-11 | 1990-05-22 | Boehringer Mannheim Gmbh | Diphosphonate derivatives, pharmaceutical compositions and methods of use |
| WO1995013078A1 (en) * | 1993-11-12 | 1995-05-18 | Leiras Oy | Pharmaceutical composition and use thereof |
| GB2252322B (en) * | 1990-12-18 | 1995-07-26 | Albright & Wilson | Phosphonated oligomers and uses thereof |
| US8216601B2 (en) | 2000-11-20 | 2012-07-10 | Universite De Geneve | Endosseous implant |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH9853A (en) * | 1972-06-08 | 1976-04-13 | M Francis | Compositions for inhibiting mobilization of calcium phosphate in animal tissue and method of use thereof |
| DE2405254C2 (en) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Use of 3-amino-1-hydroxypropane-1, 1-diphosphonic acid or its water-soluble salts for influencing calcium metabolic disorders in the human or animal body |
| DE2553963A1 (en) * | 1975-12-01 | 1977-06-08 | Henkel & Cie Gmbh | Medicaments for treating calcium metabolism disorders - contg. calcitonin and a phosphonic acid or cyclohexane-hexacarboxylic acid |
| DE2553962A1 (en) * | 1975-12-01 | 1977-06-08 | Henkel & Cie Gmbh | Medicaments for treating calcium metabolism disorders - contg. calcitonin and a phosphonic acid or cyclohexane-hexacarboxylic acid |
| DE19675047I2 (en) * | 1982-04-15 | 2003-06-12 | Gentili Ist Spa | Pharmaceutical composition containing 4-amino-1-hydroxybutane-1, 1-biphosphonic acid |
| DE3425812A1 (en) * | 1984-07-13 | 1986-01-16 | Deutsches Krebsforschungszentrum, 6900 Heidelberg | NEW 1-HYDROXY-1,1-DIPHOSPHONIC ACID COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PHARMACOLOGICAL PREPARATIONS, IN PARTICULAR FOR THE TREATMENT OF BONE TUMORS |
| DE3428524A1 (en) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| GB8530603D0 (en) * | 1985-12-12 | 1986-01-22 | Leo Pharm Prod Ltd | Chemical compounds |
-
1968
- 1968-12-09 PH PH9822A patent/PH9776A/en unknown
- 1968-12-10 AT AT1201868A patent/AT307135B/en not_active IP Right Cessation
- 1968-12-10 CA CA037,390A patent/CA946290A/en not_active Expired
- 1968-12-10 BE BE725208D patent/BE725208A/xx not_active IP Right Cessation
- 1968-12-10 DE DE1813659A patent/DE1813659C3/en not_active Expired
- 1968-12-11 NL NL6817791.A patent/NL163719C/en not_active IP Right Cessation
- 1968-12-11 GB GB58822/68A patent/GB1254466A/en not_active Expired
- 1968-12-11 GB GB58821/68A patent/GB1254465A/en not_active Expired
- 1968-12-11 ES ES361297A patent/ES361297A1/en not_active Expired
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2118042A (en) * | 1982-04-15 | 1983-10-26 | Gentili Ist Spa | Pharmaceutical compositions containing biphosphonic acids |
| US4927814A (en) * | 1986-07-11 | 1990-05-22 | Boehringer Mannheim Gmbh | Diphosphonate derivatives, pharmaceutical compositions and methods of use |
| US4942157A (en) * | 1986-07-11 | 1990-07-17 | Boehringer Mannheim Gmbh | 1-hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid, pharmaceutical compositions and methods of use |
| GB2252322B (en) * | 1990-12-18 | 1995-07-26 | Albright & Wilson | Phosphonated oligomers and uses thereof |
| WO1995013078A1 (en) * | 1993-11-12 | 1995-05-18 | Leiras Oy | Pharmaceutical composition and use thereof |
| US8216601B2 (en) | 2000-11-20 | 2012-07-10 | Universite De Geneve | Endosseous implant |
| US8802123B2 (en) | 2000-11-20 | 2014-08-12 | Universite De Geneve | Endosseous implant |
| US9730795B2 (en) | 2000-11-20 | 2017-08-15 | Universite De Geneve | Endosseous implant |
Also Published As
| Publication number | Publication date |
|---|---|
| CA946290A (en) | 1974-04-30 |
| NL163719B (en) | 1980-05-16 |
| AT307135B (en) | 1973-05-10 |
| DE1813659B2 (en) | 1974-04-18 |
| ES361297A1 (en) | 1971-02-16 |
| BE725208A (en) | 1969-06-10 |
| NL6817791A (en) | 1969-06-13 |
| GB1254466A (en) | 1971-11-24 |
| NL163719C (en) | 1980-10-15 |
| DE1813659A1 (en) | 1969-07-03 |
| DE1813659C3 (en) | 1974-11-14 |
| PH9776A (en) | 1976-03-17 |
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