GB1401548A - Compositions for inhibiting mobilization of calcium phosphate in animal tissue - Google Patents
Compositions for inhibiting mobilization of calcium phosphate in animal tissueInfo
- Publication number
- GB1401548A GB1401548A GB2745773A GB2745773A GB1401548A GB 1401548 A GB1401548 A GB 1401548A GB 2745773 A GB2745773 A GB 2745773A GB 2745773 A GB2745773 A GB 2745773A GB 1401548 A GB1401548 A GB 1401548A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxycholecalciferol
- acid
- dihydroxycholecalciferol
- hydroxy
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
Abstract
1401548 Pharmaceutical compositions PROCTER & GAMBLE CO 8 June 1973 [8 June 1972 17 May 1973] 27457/73 Heading A5B Pharmaceutical compositions for inhibiting mobilisation of calcium phosphate in animal tissue useful in the treatment of osteoporosis and Paget's disease comprises (1) at least one polyphosphonate selected from the compounds wherein each R is H or CH 2 OH and n is an integer of from 3 to 10 wherein R 1 is H, C 1-20 alkyl, C 2-20 alkenyl, aryl (e.g. phenyl or naphthyl), phenylethenyl, benzyl, halogen (e.g. Cl, Br, or F), hydroxy, amino, substituted amino (e.g. dimethylamino, diethylamino, N-hydroxy-N-ethylamino or acetylamino), -CH 2 COOH, -CH 2 PO 3 H 2 , -CH- (PO 3 H 2 )(OH) or -[CH 2 C(PO 3 H 2 ) 2 ] n -H wherein n is 1 to 15, and R 2 is hydrogen, C 1-4 alkyl, amino, benzyl, halogen, hydroxyl, -CH 2 COOH, -CH 2 PO 3 H 2 , or -CH 2 CH 2 PO 3 H 2 , wherein n is from 3 to 9, wherein each R 3 is hydrogen or C 1-4 alkyl, wherein n is from 2 to 4, wherein X and Y are each hydrogen or hydroxy or a pharmaceutically acceptable salt thereof e.g. an alkali metal (Na or K), alkaline earth metal (Ca or Mg), non-toxic heavy metal (stannous or indium), ammonium or substituteed ammonium (mono-, di- or triethanolamine) salts, and (2) at least one antirachitic compound selected from vitamin D 2 , vitamin D 3 , dihydroxytachysterol 2 , dihydrotachysterol 3 , 25-hydroxydihydrotachysterol 3 , 25-hydroxyergocalciferol, 25-hydroxycholecalciferol, 1α, 25-. dihydroxycholecalciferol, 5, 6-trans-cholecalciferol, 5, 6-trans-25-hydroxycholecalciferol, 24- nor-25-hydroxycholecalciferol, 24-nor-5, 6-trans 25-hydroxycholecalciferol, 21, 25-dihydroxycholecalciferol, 25, 26-dihydroxycholecalciferol, 24, 25-dihydroxycholecalciferol, and 1α- hydroxycholecalciferol. The polyphosphonate is preferably ethane-1-hydroxy-1, 1-diphosphonic acid, dichloromethandiphosphonic acid, tris(phosphonomethyl)amine, methanecyclohexylhydroxydiphosphonic acid 3, 3, 4, 4, 5, 5- hexafluoro-1, 2-diphosphonocyclopent-1-ene, cyclic tetraphosphonic acid, ethene-1, 2-dicarboxy-1-phosphonic acid or ethane-1, 2-dicarboxy-1, 2-diphosphonic acid. The compositions may be administered orally or parenterally in the form of solutions, elixiers, capsules, tablets, or pills.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26093972A | 1972-06-08 | 1972-06-08 | |
US36135473A | 1973-05-17 | 1973-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1401548A true GB1401548A (en) | 1975-07-16 |
Family
ID=26948280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2745773A Expired GB1401548A (en) | 1972-06-08 | 1973-06-08 | Compositions for inhibiting mobilization of calcium phosphate in animal tissue |
Country Status (8)
Country | Link |
---|---|
AU (1) | AU474216B2 (en) |
CA (1) | CA1007987A (en) |
DE (2) | DE2366498C2 (en) |
FR (1) | FR2187292B1 (en) |
GB (1) | GB1401548A (en) |
IE (1) | IE37774B1 (en) |
NL (1) | NL176747C (en) |
PH (1) | PH9853A (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2553962A1 (en) * | 1975-12-01 | 1977-06-08 | Henkel & Cie Gmbh | Medicaments for treating calcium metabolism disorders - contg. calcitonin and a phosphonic acid or cyclohexane-hexacarboxylic acid |
DE2553963A1 (en) * | 1975-12-01 | 1977-06-08 | Henkel & Cie Gmbh | Medicaments for treating calcium metabolism disorders - contg. calcitonin and a phosphonic acid or cyclohexane-hexacarboxylic acid |
JPS603045B2 (en) * | 1976-04-19 | 1985-01-25 | 中外製薬株式会社 | Method for producing 1α-hydroxyvitamin D soft capsules |
AU2649977A (en) * | 1976-07-15 | 1979-01-04 | Procter & Gamble | Pharmaceutical composition |
DE3147189A1 (en) * | 1981-11-27 | 1983-06-01 | Siemens AG, 1000 Berlin und 8000 München | Tension relief for a cable which is to be held inside a test plug |
IT1201087B (en) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | PHARMACOLOGICALLY ACTIVE BIPPHOSPHONES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS |
DE3540150A1 (en) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH9776A (en) * | 1967-12-11 | 1976-03-17 | M Francis | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue and method of use |
PH9573A (en) * | 1968-03-04 | 1976-01-16 | M Francis | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue and method of use thereof |
US3584125A (en) * | 1968-12-23 | 1971-06-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
-
1973
- 1973-06-01 PH PH14686A patent/PH9853A/en unknown
- 1973-06-02 DE DE19732366498 patent/DE2366498C2/de not_active Expired
- 1973-06-02 DE DE19732328234 patent/DE2328234C2/en not_active Expired
- 1973-06-07 AU AU56624/73A patent/AU474216B2/en not_active Expired
- 1973-06-07 CA CA173,483A patent/CA1007987A/en not_active Expired
- 1973-06-07 FR FR7320810A patent/FR2187292B1/fr not_active Expired
- 1973-06-08 IE IE93573A patent/IE37774B1/en unknown
- 1973-06-08 GB GB2745773A patent/GB1401548A/en not_active Expired
- 1973-06-08 NL NL7308017A patent/NL176747C/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA1007987A (en) | 1977-04-05 |
DE2366498C2 (en) | 1987-08-20 |
AU474216B2 (en) | 1976-07-15 |
NL7308017A (en) | 1973-12-11 |
NL176747B (en) | 1985-01-02 |
DE2328234C2 (en) | 1983-03-10 |
IE37774B1 (en) | 1977-10-12 |
AU5662473A (en) | 1974-12-12 |
FR2187292A1 (en) | 1974-01-18 |
NL176747C (en) | 1985-06-03 |
DE2366498A1 (en) | 1982-09-23 |
DE2328234A1 (en) | 1974-01-03 |
IE37774L (en) | 1973-12-08 |
FR2187292B1 (en) | 1976-12-31 |
PH9853A (en) | 1976-04-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3962432A (en) | Method of treatment of calcium disorders using aminoalkane-diophosphonic acids | |
US3678154A (en) | Oral compositions for calculus retardation | |
US4230700A (en) | Methods for inhibiting mobilization of calcium phosphate in animal tissue | |
US3965254A (en) | Compositions for the treatment of calcific tumors | |
US3488419A (en) | Oral compositions for calculus retardation | |
US4330537A (en) | Compositions for inhibiting mobilization of calcium phosphate in animal tissue | |
US4134969A (en) | Method of treatment of calcium disorders using aminoalkane-diphosphonic acids | |
US3941772A (en) | Azacycloalkane-2,2-diphosphonic acids | |
US3988443A (en) | Azacycloalkane-2,2-diphosphonic acids | |
DK174584B1 (en) | Kits for use in cheese porous cure and use of polyphosphonate for the production of kits | |
US3983227A (en) | Dry mixture containing diphosphonates and a stannous salt useful in the preparation of Tc99M containing bone scanning agents | |
JP2515929B2 (en) | Macrocyclic aminophosphonic acid complex, its production, formulation and use | |
US4330530A (en) | Anti-arthritic compositions and method using gold salts and organophosphonates | |
US3962433A (en) | Method of treatment of calcium disorders using phosphonoalkane-polycarboxylic acids | |
EP0833643A4 (en) | Anhydrous alendronate monosodium salt formulations | |
NZ332314A (en) | Oral pharmaceutical preparation containing ibandronate or salts thereof in the form of an inner section containing the active ingredient surrounded by a coating free of the active ingredient | |
GB1401548A (en) | Compositions for inhibiting mobilization of calcium phosphate in animal tissue | |
US3584124A (en) | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue | |
CA1219595A (en) | Boron containing polyphosphonates for the treatment of calcific tumors | |
JPS6133117A (en) | Kit for treating bone disease | |
GB1508899A (en) | Technetium 99-m labelled radio-diagnostic agents non-radioactive carriers therefor and method of preparation thereo | |
NL8200298A (en) | PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT OF OSTEOPATHIES. | |
GB1254465A (en) | Composition for inhibiting anomalous deposition and mobilization of calcium phosphate in human tissue | |
US3678164A (en) | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue | |
US4634691A (en) | Method for inhibiting tumor metastasis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |