GB1250304A - - Google Patents

Info

Publication number
GB1250304A
GB1250304A GB1193770A GB1193770A GB1250304A GB 1250304 A GB1250304 A GB 1250304A GB 1193770 A GB1193770 A GB 1193770A GB 1193770 A GB1193770 A GB 1193770A GB 1250304 A GB1250304 A GB 1250304A
Authority
GB
United Kingdom
Prior art keywords
component
weight
compositions
parts
oxytetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1193770A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1250304A publication Critical patent/GB1250304A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1,250,304. Stable oxytetracycline compositions. DIAMOND SHAMROCK CORP. 12 March, 1970 [13 March, 1969; 4 Feb., 1970], No. 11937/70. Heading A5B. [Also in Division C2] Stable, injectable antibiotic compositions for parenteral administration comprise (a) 0.1 to 15 parts by weight of oxytetracycline base or an acid addition salt thereof, (b) a watersoluble magnesium salt present in a molar ratio of 0.5 to 2 moles per mole of the antibiotic, (c) 50 to 95 parts by weight of a glycerol formal selected from 4-hydroxymethyl-1,3- dioxolane and/or 5-hydroxy-1,3-dioxane, (d) 0 to 45 parts by weight of water, (e) an antioxidant in an amount sufficient to stabilize the composition, and (f) a buffering agent in an amount sufficient to impart a pH of 6 to 9.5 to the composition. Component (a) may be oxytetracycline hydrochloride, phosphate, sulphate or acetate; component (b) may be magnesium chloride, acetate, sulphate, gluconate, glucoheptonate or phosphate; component (e) may be sodium bisulphite, metabisulphite or formaldehyde-sulphoxylate; and component (f) may be sodium hydroxide, potassium carbonate, ammonia, ethanolamine, diethylamine, ethylamine, triethanolamine, diethanolamine, arginine or glucosamine. The compositions may also contain ethanol.
GB1193770A 1969-03-13 1970-03-12 Expired GB1250304A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80712169A 1969-03-13 1969-03-13
US874770A 1970-02-04 1970-02-04

Publications (1)

Publication Number Publication Date
GB1250304A true GB1250304A (en) 1971-10-20

Family

ID=26678568

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1193770A Expired GB1250304A (en) 1969-03-13 1970-03-12

Country Status (8)

Country Link
BE (1) BE747255A (en)
CY (1) CY656A (en)
DE (1) DE2011793A1 (en)
FR (1) FR2034890B1 (en)
GB (1) GB1250304A (en)
IE (1) IE34075B1 (en)
MY (1) MY7300168A (en)
NL (1) NL141086B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038013A2 (en) * 1980-04-10 1981-10-21 Sds Biotech Corporation Injectable oxytetracycline compositions
WO2007130848A2 (en) * 2006-05-03 2007-11-15 Warsaw Orthopedic, Inc Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
US8057458B2 (en) 2006-10-30 2011-11-15 Warsaw Orthopedic, Inc. Method for treating facet pain
US8153112B2 (en) 2007-08-03 2012-04-10 Warsaw Orthopedic, Inc. Compositions and methods for treating cavity conditions
US8840933B2 (en) 2006-05-03 2014-09-23 Warsaw Orthopedic, Inc. Method of treating neuronal injury by administering magnesium chloride and PEG
US8852566B2 (en) 2009-03-26 2014-10-07 Warsaw Orthopedic, Inc. Compositions and methods for preferential distribution of active agents to injury sites
US8858924B2 (en) 2009-03-26 2014-10-14 Warsaw Orthopedic, Inc. Compositions and methods for treatment of hemorrhage
US8956667B2 (en) 2009-03-26 2015-02-17 Warsaw Orthopedic, Inc. Methods of identifying potential components for targeted drug delivery compositions
US9078808B2 (en) 2009-03-26 2015-07-14 Warsaw Orthopedic, Inc. Device to deliver magnesium in PEG formulation
US9244060B2 (en) 2009-03-26 2016-01-26 Warsaw Orthopedic, Inc. Site localization and methods for monitoring treatment of disturbed blood vessels
US9597352B2 (en) 2005-05-31 2017-03-21 Warsaw Orthopedic, Inc. Compositions and methods for treating pain
US9675696B2 (en) 2006-11-14 2017-06-13 Warsaw Orthopedic, Inc. Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9413873D0 (en) * 1994-07-09 1994-08-31 Norbrook Lab Ltd Long-acting oxytetracycline composition
US6110905A (en) * 1994-07-09 2000-08-29 Norbrook Laboratories Limited Long-acting oxytetracycline composition
US6310053B1 (en) 1995-07-05 2001-10-30 Norbrook Laboratories Limited Long-acting oxytetracycline composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004894A (en) * 1959-04-07 1961-10-17 Upjohn Co Therapeutic composition comprising tetracycline and a dioxolane
US3140232A (en) * 1962-12-19 1964-07-07 Pfizer & Co C Color stabilization of tetracycline compositions with polypropylene glycols

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038013A3 (en) * 1980-04-10 1982-09-22 Sds Biotech Corporation Injectable oxytetracycline compositions
EP0038013A2 (en) * 1980-04-10 1981-10-21 Sds Biotech Corporation Injectable oxytetracycline compositions
US9597352B2 (en) 2005-05-31 2017-03-21 Warsaw Orthopedic, Inc. Compositions and methods for treating pain
US9950005B2 (en) 2006-05-03 2018-04-24 Warsaw Orthopedic, Inc. Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
JP2009535416A (en) * 2006-05-03 2009-10-01 ウォーソー・オーソペディック・インコーポレーテッド Compositions containing biomembrane sealing agents for the treatment of nerve damage and methods of use
JP2014074061A (en) * 2006-05-03 2014-04-24 Warsaw Orthopaedic Inc Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
US8840933B2 (en) 2006-05-03 2014-09-23 Warsaw Orthopedic, Inc. Method of treating neuronal injury by administering magnesium chloride and PEG
WO2007130848A3 (en) * 2006-05-03 2008-01-24 Warsaw Orthopedic Inc Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
WO2007130848A2 (en) * 2006-05-03 2007-11-15 Warsaw Orthopedic, Inc Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
US8945623B2 (en) 2006-05-03 2015-02-03 Warsaw Orthopedic, Inc. Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
US9717756B2 (en) 2006-05-03 2017-08-01 Warsaw Orthopedic, Inc. Method of treating traumatic brain or spinal cord injury with biomembrane sealing agent and magnesium compounds
US8057458B2 (en) 2006-10-30 2011-11-15 Warsaw Orthopedic, Inc. Method for treating facet pain
US9675696B2 (en) 2006-11-14 2017-06-13 Warsaw Orthopedic, Inc. Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain
US8153112B2 (en) 2007-08-03 2012-04-10 Warsaw Orthopedic, Inc. Compositions and methods for treating cavity conditions
US8858924B2 (en) 2009-03-26 2014-10-14 Warsaw Orthopedic, Inc. Compositions and methods for treatment of hemorrhage
US9452183B2 (en) 2009-03-26 2016-09-27 Warsaw Orthopedic, Inc. Compositions and methods for treatment of hemorrhage
US9486478B2 (en) 2009-03-26 2016-11-08 Warsaw Orthopedic, Inc. Compositions and methods for preferential distribution of active agents to injury sites
US9244060B2 (en) 2009-03-26 2016-01-26 Warsaw Orthopedic, Inc. Site localization and methods for monitoring treatment of disturbed blood vessels
US9078808B2 (en) 2009-03-26 2015-07-14 Warsaw Orthopedic, Inc. Device to deliver magnesium in PEG formulation
US8956667B2 (en) 2009-03-26 2015-02-17 Warsaw Orthopedic, Inc. Methods of identifying potential components for targeted drug delivery compositions
US8852566B2 (en) 2009-03-26 2014-10-07 Warsaw Orthopedic, Inc. Compositions and methods for preferential distribution of active agents to injury sites
US10883976B2 (en) 2009-03-26 2021-01-05 Warsaw Orthopedic, Inc. Methods of identifying potential components for targeted drug delivery compositions

Also Published As

Publication number Publication date
FR2034890B1 (en) 1974-05-24
NL7003555A (en) 1970-09-15
MY7300168A (en) 1973-12-31
BE747255A (en) 1970-09-14
FR2034890A1 (en) 1970-12-18
CY656A (en) 1972-09-11
DE2011793A1 (en) 1970-09-17
IE34075B1 (en) 1975-01-22
IE34075L (en) 1970-09-13
NL141086B (en) 1974-02-15

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee