GB1250304A - - Google Patents
Info
- Publication number
- GB1250304A GB1250304A GB1193770A GB1193770A GB1250304A GB 1250304 A GB1250304 A GB 1250304A GB 1193770 A GB1193770 A GB 1193770A GB 1193770 A GB1193770 A GB 1193770A GB 1250304 A GB1250304 A GB 1250304A
- Authority
- GB
- United Kingdom
- Prior art keywords
- component
- weight
- compositions
- parts
- oxytetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1,250,304. Stable oxytetracycline compositions. DIAMOND SHAMROCK CORP. 12 March, 1970 [13 March, 1969; 4 Feb., 1970], No. 11937/70. Heading A5B. [Also in Division C2] Stable, injectable antibiotic compositions for parenteral administration comprise (a) 0.1 to 15 parts by weight of oxytetracycline base or an acid addition salt thereof, (b) a watersoluble magnesium salt present in a molar ratio of 0.5 to 2 moles per mole of the antibiotic, (c) 50 to 95 parts by weight of a glycerol formal selected from 4-hydroxymethyl-1,3- dioxolane and/or 5-hydroxy-1,3-dioxane, (d) 0 to 45 parts by weight of water, (e) an antioxidant in an amount sufficient to stabilize the composition, and (f) a buffering agent in an amount sufficient to impart a pH of 6 to 9.5 to the composition. Component (a) may be oxytetracycline hydrochloride, phosphate, sulphate or acetate; component (b) may be magnesium chloride, acetate, sulphate, gluconate, glucoheptonate or phosphate; component (e) may be sodium bisulphite, metabisulphite or formaldehyde-sulphoxylate; and component (f) may be sodium hydroxide, potassium carbonate, ammonia, ethanolamine, diethylamine, ethylamine, triethanolamine, diethanolamine, arginine or glucosamine. The compositions may also contain ethanol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80712169A | 1969-03-13 | 1969-03-13 | |
US874770A | 1970-02-04 | 1970-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1250304A true GB1250304A (en) | 1971-10-20 |
Family
ID=26678568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1193770A Expired GB1250304A (en) | 1969-03-13 | 1970-03-12 |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE747255A (en) |
CY (1) | CY656A (en) |
DE (1) | DE2011793A1 (en) |
FR (1) | FR2034890B1 (en) |
GB (1) | GB1250304A (en) |
IE (1) | IE34075B1 (en) |
MY (1) | MY7300168A (en) |
NL (1) | NL141086B (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0038013A2 (en) * | 1980-04-10 | 1981-10-21 | Sds Biotech Corporation | Injectable oxytetracycline compositions |
WO2007130848A2 (en) * | 2006-05-03 | 2007-11-15 | Warsaw Orthopedic, Inc | Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use |
US8057458B2 (en) | 2006-10-30 | 2011-11-15 | Warsaw Orthopedic, Inc. | Method for treating facet pain |
US8153112B2 (en) | 2007-08-03 | 2012-04-10 | Warsaw Orthopedic, Inc. | Compositions and methods for treating cavity conditions |
US8840933B2 (en) | 2006-05-03 | 2014-09-23 | Warsaw Orthopedic, Inc. | Method of treating neuronal injury by administering magnesium chloride and PEG |
US8852566B2 (en) | 2009-03-26 | 2014-10-07 | Warsaw Orthopedic, Inc. | Compositions and methods for preferential distribution of active agents to injury sites |
US8858924B2 (en) | 2009-03-26 | 2014-10-14 | Warsaw Orthopedic, Inc. | Compositions and methods for treatment of hemorrhage |
US8956667B2 (en) | 2009-03-26 | 2015-02-17 | Warsaw Orthopedic, Inc. | Methods of identifying potential components for targeted drug delivery compositions |
US9078808B2 (en) | 2009-03-26 | 2015-07-14 | Warsaw Orthopedic, Inc. | Device to deliver magnesium in PEG formulation |
US9244060B2 (en) | 2009-03-26 | 2016-01-26 | Warsaw Orthopedic, Inc. | Site localization and methods for monitoring treatment of disturbed blood vessels |
US9597352B2 (en) | 2005-05-31 | 2017-03-21 | Warsaw Orthopedic, Inc. | Compositions and methods for treating pain |
US9675696B2 (en) | 2006-11-14 | 2017-06-13 | Warsaw Orthopedic, Inc. | Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9413873D0 (en) * | 1994-07-09 | 1994-08-31 | Norbrook Lab Ltd | Long-acting oxytetracycline composition |
US6110905A (en) * | 1994-07-09 | 2000-08-29 | Norbrook Laboratories Limited | Long-acting oxytetracycline composition |
US6310053B1 (en) | 1995-07-05 | 2001-10-30 | Norbrook Laboratories Limited | Long-acting oxytetracycline composition |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3004894A (en) * | 1959-04-07 | 1961-10-17 | Upjohn Co | Therapeutic composition comprising tetracycline and a dioxolane |
US3140232A (en) * | 1962-12-19 | 1964-07-07 | Pfizer & Co C | Color stabilization of tetracycline compositions with polypropylene glycols |
-
1970
- 1970-03-12 IE IE33070A patent/IE34075B1/en unknown
- 1970-03-12 GB GB1193770A patent/GB1250304A/en not_active Expired
- 1970-03-12 NL NL7003555A patent/NL141086B/en not_active IP Right Cessation
- 1970-03-12 DE DE19702011793 patent/DE2011793A1/en not_active Withdrawn
- 1970-03-12 BE BE747255D patent/BE747255A/en not_active IP Right Cessation
- 1970-03-12 FR FR7008848A patent/FR2034890B1/fr not_active Expired
-
1972
- 1972-09-11 CY CY65672A patent/CY656A/en unknown
-
1973
- 1973-12-30 MY MY7300168A patent/MY7300168A/en unknown
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0038013A3 (en) * | 1980-04-10 | 1982-09-22 | Sds Biotech Corporation | Injectable oxytetracycline compositions |
EP0038013A2 (en) * | 1980-04-10 | 1981-10-21 | Sds Biotech Corporation | Injectable oxytetracycline compositions |
US9597352B2 (en) | 2005-05-31 | 2017-03-21 | Warsaw Orthopedic, Inc. | Compositions and methods for treating pain |
US9950005B2 (en) | 2006-05-03 | 2018-04-24 | Warsaw Orthopedic, Inc. | Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use |
JP2009535416A (en) * | 2006-05-03 | 2009-10-01 | ウォーソー・オーソペディック・インコーポレーテッド | Compositions containing biomembrane sealing agents for the treatment of nerve damage and methods of use |
JP2014074061A (en) * | 2006-05-03 | 2014-04-24 | Warsaw Orthopaedic Inc | Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use |
US8840933B2 (en) | 2006-05-03 | 2014-09-23 | Warsaw Orthopedic, Inc. | Method of treating neuronal injury by administering magnesium chloride and PEG |
WO2007130848A3 (en) * | 2006-05-03 | 2008-01-24 | Warsaw Orthopedic Inc | Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use |
WO2007130848A2 (en) * | 2006-05-03 | 2007-11-15 | Warsaw Orthopedic, Inc | Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use |
US8945623B2 (en) | 2006-05-03 | 2015-02-03 | Warsaw Orthopedic, Inc. | Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use |
US9717756B2 (en) | 2006-05-03 | 2017-08-01 | Warsaw Orthopedic, Inc. | Method of treating traumatic brain or spinal cord injury with biomembrane sealing agent and magnesium compounds |
US8057458B2 (en) | 2006-10-30 | 2011-11-15 | Warsaw Orthopedic, Inc. | Method for treating facet pain |
US9675696B2 (en) | 2006-11-14 | 2017-06-13 | Warsaw Orthopedic, Inc. | Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain |
US8153112B2 (en) | 2007-08-03 | 2012-04-10 | Warsaw Orthopedic, Inc. | Compositions and methods for treating cavity conditions |
US8858924B2 (en) | 2009-03-26 | 2014-10-14 | Warsaw Orthopedic, Inc. | Compositions and methods for treatment of hemorrhage |
US9452183B2 (en) | 2009-03-26 | 2016-09-27 | Warsaw Orthopedic, Inc. | Compositions and methods for treatment of hemorrhage |
US9486478B2 (en) | 2009-03-26 | 2016-11-08 | Warsaw Orthopedic, Inc. | Compositions and methods for preferential distribution of active agents to injury sites |
US9244060B2 (en) | 2009-03-26 | 2016-01-26 | Warsaw Orthopedic, Inc. | Site localization and methods for monitoring treatment of disturbed blood vessels |
US9078808B2 (en) | 2009-03-26 | 2015-07-14 | Warsaw Orthopedic, Inc. | Device to deliver magnesium in PEG formulation |
US8956667B2 (en) | 2009-03-26 | 2015-02-17 | Warsaw Orthopedic, Inc. | Methods of identifying potential components for targeted drug delivery compositions |
US8852566B2 (en) | 2009-03-26 | 2014-10-07 | Warsaw Orthopedic, Inc. | Compositions and methods for preferential distribution of active agents to injury sites |
US10883976B2 (en) | 2009-03-26 | 2021-01-05 | Warsaw Orthopedic, Inc. | Methods of identifying potential components for targeted drug delivery compositions |
Also Published As
Publication number | Publication date |
---|---|
FR2034890B1 (en) | 1974-05-24 |
NL7003555A (en) | 1970-09-15 |
MY7300168A (en) | 1973-12-31 |
BE747255A (en) | 1970-09-14 |
FR2034890A1 (en) | 1970-12-18 |
CY656A (en) | 1972-09-11 |
DE2011793A1 (en) | 1970-09-17 |
IE34075B1 (en) | 1975-01-22 |
IE34075L (en) | 1970-09-13 |
NL141086B (en) | 1974-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |