GB1242109A - New isopropylamine derivatives and process for the preparation thereof - Google Patents
New isopropylamine derivatives and process for the preparation thereofInfo
- Publication number
- GB1242109A GB1242109A GB50419/68A GB5041968A GB1242109A GB 1242109 A GB1242109 A GB 1242109A GB 50419/68 A GB50419/68 A GB 50419/68A GB 5041968 A GB5041968 A GB 5041968A GB 1242109 A GB1242109 A GB 1242109A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- compounds
- cycloalkynyl
- cycloalkenyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Door And Window Frames Mounted To Openings (AREA)
Abstract
1,242,109. Isopropylamine derivatives. CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT. 23 Oct., 1968 [25 Oct., 1967], No. 50419/68. Heading C2C. Novel compounds I in which A is -C(CH 3 ) = N-R<SP>2</SP>, or -CH(CH 3 )-N(R 1 )R 2 ; R<SP>1</SP> is H, or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl or aryl group; R<SP>2</SP> is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl or amino group and R<SP>3</SP> is H, halo, NO 2 , NH 2 , OH or alkoxy and their salts are prepared by reaction of a compound II with a compound III where B and E represent groups capable of reacting together to form =N- or -N(R 1 )- and R<SP>4</SP> is as R<SP>2</SP>. Compounds I where A is -CH(CH 3 )-NR<SP>1</SP>R<SP>2</SP> may be prepared by reduction of compounds I where A is -C(CH 3 )=N-R<SP>2</SP>. Pharmaceutical compositions comprise a compound I together with a suitable carrier and/or diluent, are administered orally, topically, rectally and parenterally and have psychostimulant properties.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUCI000744 | 1967-10-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1242109A true GB1242109A (en) | 1971-08-11 |
Family
ID=10994342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB50419/68A Expired GB1242109A (en) | 1967-10-25 | 1968-10-23 | New isopropylamine derivatives and process for the preparation thereof |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS4927175B1 (en) |
AT (3) | AT298476B (en) |
CH (3) | CH545267A (en) |
DE (1) | DE1802297C3 (en) |
FR (1) | FR8347M (en) |
GB (1) | GB1242109A (en) |
IL (1) | IL30910A (en) |
NO (1) | NO123892B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2284810A (en) * | 1993-12-16 | 1995-06-21 | Russinsky Ltd | Alkenylation and alkynylation of phenylisopropylamine derivatives with tertiary amine base |
US20100317582A1 (en) * | 2007-11-23 | 2010-12-16 | Leo Pharma A/S | Novel cyclic hydrocarbon compounds for the treatment of diseases |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5231172U (en) * | 1975-08-27 | 1977-03-04 | ||
JPS5497972U (en) * | 1977-12-22 | 1979-07-11 | ||
JPS5523400U (en) * | 1979-07-09 | 1980-02-15 | ||
JP3839049B2 (en) * | 1994-06-03 | 2006-11-01 | テムド トラスト | Meta-substituted allylalkylamines and their use for therapy and diagnosis |
-
1968
- 1968-10-10 DE DE1802297A patent/DE1802297C3/en not_active Expired
- 1968-10-16 AT AT938470A patent/AT298476B/en not_active IP Right Cessation
- 1968-10-16 AT AT1008368A patent/AT292684B/en active
- 1968-10-16 AT AT938570A patent/AT299172B/en not_active IP Right Cessation
- 1968-10-17 CH CH344171A patent/CH545267A/en not_active IP Right Cessation
- 1968-10-17 CH CH344071A patent/CH555800A/en not_active IP Right Cessation
- 1968-10-17 CH CH1555468A patent/CH512423A/en not_active IP Right Cessation
- 1968-10-21 IL IL30910A patent/IL30910A/en unknown
- 1968-10-23 GB GB50419/68A patent/GB1242109A/en not_active Expired
- 1968-10-24 NO NO4210/68A patent/NO123892B/no unknown
- 1968-10-25 JP JP43077443A patent/JPS4927175B1/ja active Pending
-
1969
- 1969-01-23 FR FR171249A patent/FR8347M/fr not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2284810A (en) * | 1993-12-16 | 1995-06-21 | Russinsky Ltd | Alkenylation and alkynylation of phenylisopropylamine derivatives with tertiary amine base |
GB2284810B (en) * | 1993-12-16 | 1998-07-08 | Russinsky Ltd | A process for producing Selegiline |
US20100317582A1 (en) * | 2007-11-23 | 2010-12-16 | Leo Pharma A/S | Novel cyclic hydrocarbon compounds for the treatment of diseases |
US9487494B2 (en) * | 2007-11-23 | 2016-11-08 | Leo Pharma A/S | Cyclic hydrocarbon compounds for the treatment of diseases |
Also Published As
Publication number | Publication date |
---|---|
DE1802297C3 (en) | 1974-10-17 |
CH512423A (en) | 1971-09-15 |
CH545267A (en) | 1974-01-31 |
IL30910A (en) | 1973-11-28 |
IL30910A0 (en) | 1968-12-26 |
NO123892B (en) | 1972-01-31 |
FR8347M (en) | 1970-12-21 |
CH555800A (en) | 1974-11-15 |
AT299172B (en) | 1972-06-12 |
AT292684B (en) | 1971-09-10 |
JPS4927175B1 (en) | 1974-07-16 |
AT298476B (en) | 1972-05-10 |
DE1802297B2 (en) | 1974-02-28 |
DE1802297A1 (en) | 1969-07-24 |
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