GB1238597A - - Google Patents

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Publication number
GB1238597A
GB1238597A GB1238597DA GB1238597A GB 1238597 A GB1238597 A GB 1238597A GB 1238597D A GB1238597D A GB 1238597DA GB 1238597 A GB1238597 A GB 1238597A
Authority
GB
United Kingdom
Prior art keywords
diepoxybutane
epichlorohydrin
reacted
june
mixed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1238597A publication Critical patent/GB1238597A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,238,597. Antihypercholesteroleamics. UPJOHN CO. 12 June, 1969 [17 June, 1968], No. 29884/69. Heading A5B. [Also in Division C3] A pharmaceutical composition for treating hypercholesteremia comprises a polymeric reaction product of a polyethyleneimine of formula NH 2 -(CH 2 CH 2 NH) n -H, where n is from 4 to 1,000, with epichlorohydrin, glycerol- 1,3-dichlorohydrin, 1,2:3,4-diepoxybutane, bisepoxypropyl ether, ethylene glycol bis-epoxypropyl ether, 1,4-butane diol bis-epoxypropyl ether or an epoxide of formula where R is a hydrogen atom or an alkyl or phenyl group, or an acid addition salt of such reaction product, and a compatible edible oral carrier. In examples tetraethylene pentamine is reacted with epichlorohydrin and with 1,2:3,4- diepoxybutane, polyethyleneimines are reacted with epichlorohydrin, glycidol and ethylene oxide, and pentaethylene hexamine is reacted with 1,2:3,4-diepoxybutane; the reaction products are added to foodstuffs, mixed with talc and magnesium stearate and filled into gelatin capsules, mixed with soybean oil and linseed oil gelled with aluminium monostearate, and made into an aqueous suspension with pectin and deionized water. Other ingredients which may be added are mentioned.
GB1238597D 1968-06-17 1969-06-12 Expired GB1238597A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73736568A 1968-06-17 1968-06-17

Publications (1)

Publication Number Publication Date
GB1238597A true GB1238597A (en) 1971-07-07

Family

ID=24963633

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1238597D Expired GB1238597A (en) 1968-06-17 1969-06-12

Country Status (4)

Country Link
BE (1) BE734691A (en)
DE (1) DE1927336A1 (en)
FR (1) FR2011073A1 (en)
GB (1) GB1238597A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081291A2 (en) * 1981-11-04 1983-06-15 Kabushiki Kaisha Vitamin Kenkyusho Polymer-metal complexes containing quaternary nitrogen atoms, process for preparation thereof and pharmaceutical agents comprising the same
WO1989012452A1 (en) * 1988-06-24 1989-12-28 The Upjohn Company Fine-milled colestipol hydrochloride
US5520932A (en) * 1988-06-24 1996-05-28 The Upjohn Company Fine-milled colestipol hydrochloride
EP1133989A2 (en) * 1993-08-11 2001-09-19 Geltex Pharmaceuticals, Inc. Polymer compositions for use in therapy
US7014846B2 (en) 1993-08-11 2006-03-21 Genzyme Corporation Phosphate-binding polymers for oral administration
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US8187631B2 (en) 1999-10-19 2012-05-29 Genzyme Corporation Direct compression polymer tablet core
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
US9095509B2 (en) 2005-09-15 2015-08-04 Genzyme Corporation Sachet formulation for amine polymers
US11267924B2 (en) 2014-12-18 2022-03-08 Genzyme Corporation Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE467746A (en) * 1945-09-15
US3251882A (en) * 1963-01-07 1966-05-17 Nalco Chemical Co Epichlorohydrin polyalkylene polyamine polycondensates

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081291A2 (en) * 1981-11-04 1983-06-15 Kabushiki Kaisha Vitamin Kenkyusho Polymer-metal complexes containing quaternary nitrogen atoms, process for preparation thereof and pharmaceutical agents comprising the same
EP0081291A3 (en) * 1981-11-04 1985-01-09 Kabushiki Kaisha Vitamin Kenkyusyo Polymer-metal complexes containing quaternary nitrogen atoms, process for preparation thereof and pharmaceutical agents comprising the same
WO1989012452A1 (en) * 1988-06-24 1989-12-28 The Upjohn Company Fine-milled colestipol hydrochloride
AU633491B2 (en) * 1988-06-24 1993-02-04 Pharmacia & Upjohn Company Fine-milled colestipol hydrochloride
US5520932A (en) * 1988-06-24 1996-05-28 The Upjohn Company Fine-milled colestipol hydrochloride
EP1133989A2 (en) * 1993-08-11 2001-09-19 Geltex Pharmaceuticals, Inc. Polymer compositions for use in therapy
EP1133989A3 (en) * 1993-08-11 2004-05-12 Genzyme Corporation Polymer compositions for use in therapy
US7014846B2 (en) 1993-08-11 2006-03-21 Genzyme Corporation Phosphate-binding polymers for oral administration
US7459151B2 (en) 1993-08-11 2008-12-02 Genzyme Corporation Phosphate-binding polymers for oral administration
US8187631B2 (en) 1999-10-19 2012-05-29 Genzyme Corporation Direct compression polymer tablet core
US9579343B2 (en) 1999-10-19 2017-02-28 Genzyme Corporation Direct compression polymer tablet core
US9931358B2 (en) 1999-10-19 2018-04-03 Genzyme Corporation Direct compression polymer tablet core
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US8808738B2 (en) 2004-11-01 2014-08-19 Genzyme Corporation Aliphatic amine polymer salts for tableting
US9555056B2 (en) 2004-11-01 2017-01-31 Genzyme Corporation Aliphatic amine polymer salts for tableting
US9895315B2 (en) 2004-11-01 2018-02-20 Genzyme Corporation Aliphatic amine polymer salts for tableting
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
US9095509B2 (en) 2005-09-15 2015-08-04 Genzyme Corporation Sachet formulation for amine polymers
US9585911B2 (en) 2005-09-15 2017-03-07 Genzyme Corporation Sachet formulation for amine polymers
US11267924B2 (en) 2014-12-18 2022-03-08 Genzyme Corporation Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes

Also Published As

Publication number Publication date
BE734691A (en) 1969-12-17
FR2011073A1 (en) 1970-02-27
DE1927336A1 (en) 1969-12-18

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee