GB1234702A - Improvements in or relating to ammo alkanes and the preparation thereof - Google Patents
Improvements in or relating to ammo alkanes and the preparation thereofInfo
- Publication number
- GB1234702A GB1234702A GB3511369A GB3511369A GB1234702A GB 1234702 A GB1234702 A GB 1234702A GB 3511369 A GB3511369 A GB 3511369A GB 3511369 A GB3511369 A GB 3511369A GB 1234702 A GB1234702 A GB 1234702A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrrolidino
- piperidino
- group
- pharmaceutically acceptable
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,234,702. Diaminocycloalkanes. UPJOHN CO. 21 July, 1969 [8 May, 1968], No. 35113/68. Heading C2C. The invention comprises compounds of the Formula I wherein R is a polymethylene C 3-7 group and B is the residue from a cyclic secondary amine group from which the hydrogen atom has been removed, and their pharmaceutically acceptable acid addition and quaternary ammonium salts. They are prepared by reducing the appropriate enamine with sodium borohydride. In examples R is 3 and both B groups are piperidino or both are pyrrolidino, or one is pyrrolidino and the other is piperidino, morpholino or one B group is piperidino and the other is 4-methylpiperazino or R is 4 and both B groups are pyrrolidino. The dihydrobromide, dihydrochloride, oxalate, fumarate and methiodide salts are also disclosed. 2 - Pyrrolidinocycloheptanone is prepared by reacting 2-chlorocycloheptanone with pyrrolidine. 2 - (4 - Methyl - 1 - piperazinyl) - cyclohexanol is obtained (as a by-product) from the sodium borohydride reduction of the corresponding ketone. Pharmaceutical compositions comprising as active ingredient a compound of Formula I together with a pharmaceutically acceptable carrier are administered orally or parenterally and lower the blood sugar level and have anorexigenic activity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3511369A GB1234702A (en) | 1968-05-08 | 1968-05-08 | Improvements in or relating to ammo alkanes and the preparation thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3511369A GB1234702A (en) | 1968-05-08 | 1968-05-08 | Improvements in or relating to ammo alkanes and the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1234702A true GB1234702A (en) | 1971-06-09 |
Family
ID=10373972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3511369A Expired GB1234702A (en) | 1968-05-08 | 1968-05-08 | Improvements in or relating to ammo alkanes and the preparation thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1234702A (en) |
-
1968
- 1968-05-08 GB GB3511369A patent/GB1234702A/en not_active Expired
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