GB1234702A - Improvements in or relating to ammo alkanes and the preparation thereof - Google Patents

Improvements in or relating to ammo alkanes and the preparation thereof

Info

Publication number
GB1234702A
GB1234702A GB3511369A GB3511369A GB1234702A GB 1234702 A GB1234702 A GB 1234702A GB 3511369 A GB3511369 A GB 3511369A GB 3511369 A GB3511369 A GB 3511369A GB 1234702 A GB1234702 A GB 1234702A
Authority
GB
United Kingdom
Prior art keywords
pyrrolidino
piperidino
group
pharmaceutically acceptable
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3511369A
Inventor
Jacob Szmuskovicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to GB3511369A priority Critical patent/GB1234702A/en
Publication of GB1234702A publication Critical patent/GB1234702A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,234,702. Diaminocycloalkanes. UPJOHN CO. 21 July, 1969 [8 May, 1968], No. 35113/68. Heading C2C. The invention comprises compounds of the Formula I wherein R is a polymethylene C 3-7 group and B is the residue from a cyclic secondary amine group from which the hydrogen atom has been removed, and their pharmaceutically acceptable acid addition and quaternary ammonium salts. They are prepared by reducing the appropriate enamine with sodium borohydride. In examples R is 3 and both B groups are piperidino or both are pyrrolidino, or one is pyrrolidino and the other is piperidino, morpholino or one B group is piperidino and the other is 4-methylpiperazino or R is 4 and both B groups are pyrrolidino. The dihydrobromide, dihydrochloride, oxalate, fumarate and methiodide salts are also disclosed. 2 - Pyrrolidinocycloheptanone is prepared by reacting 2-chlorocycloheptanone with pyrrolidine. 2 - (4 - Methyl - 1 - piperazinyl) - cyclohexanol is obtained (as a by-product) from the sodium borohydride reduction of the corresponding ketone. Pharmaceutical compositions comprising as active ingredient a compound of Formula I together with a pharmaceutically acceptable carrier are administered orally or parenterally and lower the blood sugar level and have anorexigenic activity.
GB3511369A 1968-05-08 1968-05-08 Improvements in or relating to ammo alkanes and the preparation thereof Expired GB1234702A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3511369A GB1234702A (en) 1968-05-08 1968-05-08 Improvements in or relating to ammo alkanes and the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3511369A GB1234702A (en) 1968-05-08 1968-05-08 Improvements in or relating to ammo alkanes and the preparation thereof

Publications (1)

Publication Number Publication Date
GB1234702A true GB1234702A (en) 1971-06-09

Family

ID=10373972

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3511369A Expired GB1234702A (en) 1968-05-08 1968-05-08 Improvements in or relating to ammo alkanes and the preparation thereof

Country Status (1)

Country Link
GB (1) GB1234702A (en)

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